PART I Nucleic Acid Diagnostic Technology
Chapter 1
Target Amplification-Based Techniques ........................... 3
Antoinette A.T.P. Brink, Peter J.F. Snijders,
and Chris J.L.M. Meijer
Chapter 2
Signal Amplification-Based Techniques .......................... 19
David A. Hendricks and Lorraine Comanor
Chapter 3
Microarrays: Human Disease Detection and Monitoring ............ 65
Janet A. Warrington and Thomas B. Broudy
Chapter 4
Bead-Based Flow Systems: From Centralized Laboratories to
Genetic Testing in the Field ................................... 93
Darrell P. Chandler
Chapter 5
In Situ Hybridization ......................................... 113
Xiang Qian and Ricardo V. Lloyd
Chapter 6
Detection Techniques for Single Nucleotide Polymorphisms ...... 139
W. Mathias Howell, Johan Stenberg, Chatarina Larsson,
Mats Nilsson, and Ulf Landegren
Chapter 7
RNA Expression Profiling ...................................... 171
Payman Hanifi-Moghaddam, Curt W. Burger,
Theo J.M. Helmerhorst, and Leen J. Blok
Chapter 8
Evolution of the Molecular Microbiology Laboratory ............ 189
Gary W. Procop and Belinda Yen-Lieberman
PART II Disease Applications of Nucleic Acid Tests
Chapter 9
Bacterial Sexually Transmitted Diseases ....................... 211
Julius Schachter and Stephen A. Morse
Chapter 10
Sexually Transmissible Viral Pathogens: Human
Papillomaviruses and Herpes Simplex Viruses ................... 243
Attila T. Lorincz and Jennifer S. Smith
Chapter 11
Blood-Borne Viruses in Clinical and Diagnostic Virology ....... 275
Hubert G.M. Niesters, Martin Schutten,
and Elisabeth Puchhammer-Stockl
Chapter 12
Molecular Methods for the Diagnosis of Fungal Infections ...... 301
Adam M. Bressler and Christine J. Morrison
Chapter 13
Molecular Diagnostic Approaches in Infectious Disease ......... 331
Leonard F. Peruski, Jr. and Anne Harwood Peruski
Chapter 14
Cancer Detection and Prognosis ................................ 353
Santiago Ropero and Manel Esteller
Chapter 15
Common Inherited Genetic Disorders ............................ 373
Madhuri Hegde and Sue Richards
Chapter 16
Future Perspectives on Nucleic Acid Testing ................... 413
Larry J. Kricka and Paolo Fortina
Chapter 17
Bridging the Gap between Analytical and Clinical Validation ... 435
Mel Krajden
Index ......................................................... 457
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