Applications of vibrational spectroscopy in pharmaceutical research development / ed. by Pivonka D.E., Chalmers J.M., Griffiths P.R. - Chichester: Wiley, 2007. - 372 p. - ISBN 978-0-470-87087-7  Место хранения:   032 | Институт органической химии им. Н.Н.Ворожцова СО РАН | Новосибирск | Библиотека

Оглавление / Contents

List of Contributors ........................................... xi Part One: Introduction Introduction to Vibrational Spectroscopy ........................ 3 Peter R. Griffiths Part Two: Drug Discovery Sampling Techniques and Fiber-Optic Probes ..................... 19 John M. Chalmers and Peter R. Griffiths Vibrational Spectroscopy in the Discovery Phase Component of Pharmaceutical Research ..................................... 51 Don E. Pivonka Applications of Vibrational Spectroscopy to Combinatorial Chemistry ...................................................... 75 Don E. Pivonka Vibrational Spectroscopic Analysis for the Determination of Structure-Activity Relationships (SARs)in Molecular Binding ... 109 Don E. Pivonka and Isao Noda Applications of Vibrational Optical Activity in the Pharmaceutical Industry ....................................... 129 Laurence A. Nafie and Rina K. Dukor Characterization and Optimization of Chemical Synthesis Using Real-Time Vibrational Spectroscopy ...................... 155 Fadi Homsi, Paul Barrett, Jian Wang and Roel Ferwerda Part Three: Drug Development Infrared and Raman Spectroscopy for Process Development ....... 185 George Zhou, Robert Guenard and Zhihong Ge The Analysis of Pharmaceutical Substances and Formulated Products by Vibrational Spectroscopy .......................... 213 Don Clark and Alexander Pysik Raman Analysis of Pharmaceuticals ............................. 239 David E. Bugay, Jan-Olav Henck, Michael L. Longmire and Fiona C. Thorley Vibrational Spectroscopy of Solid-State Forms - Introduction, Principles and Overview ......................... 263 Terry L. Threlfall and John M. Chalmers Vibrational Spectroscopy of Solid-State Forms - Applications and Examples ..................................... 293 David H. Igo and Pingyun Chen Pharmaceutical Applications of Chemical Mapping and Imaging ... 309 Don Clark, Mark Henson, Fred LaPlant, Slobodan Sasic and Lin Zhang Terahertz Spectroscopy for Pharmaceutical Applications ........ 337 Mike Claybourn, Husheng Yang, Lubomir Gradinarsky, Jonas Johansson and Staffan Folestad Part Four: Conclusions History, Trends and Prognostications .......................... 353 Peter R. Griffiths, John M. Chalmers and Don E. Pivonka Index ......................................................... 363