Prefatory Chapters
Discovery of G Protein Signaling
Zvi Selinger .................................................. 1
Moments of Discovery
Paul Berg .................................................... 14
Single-Molecule Theme
In singulo Biochemistry: When Less Is More
Carlos Bustamante ............................................ 45
Advances in Single-Molecule Fluorescence Methods for
Molecular Biology
Chirlmin Joo, Hamza Balci, Yuji Ishitsuka,
Chittanon Buranachai, and Taekjip Ha ......................... 51
How RNA Unfolds and Refolds
Pan T.X. Li, Jeffrey Vieregg, and Ignacio Tinoco, Jr. ........ 77
Single-Molecule Studies of Protein Folding
Alessandro Borgia, Philip M. Williams, and Jane Clarke ...... 101
Structure and Mechanics of Membrane Proteins
Andreas Engel and Hermann E. Gaub ........................... 127
Single-Molecule Studies of RNA Polymerase: Motoring Along
Kristina M. Herbert, William J. Greenleaf,
and Steven M. Block ......................................... 149
Translation at the Single-Molecule Level
R. Andrew Marshall, Colin Echeverría Aitken,
Magdalena Dorywalska, and Joseph D. Puglisi ................. 177
Recent Advances in Optical Tweezers
Jeffrey R. Moffitt, Yann R. Chemla, Steven B. Smith,
and Carlos Bustamante ....................................... 205
Recent Advances in Biochemistry
Mechanism of Eukaryotic Homologous Recombination
Joseph San Filippo, Patrick Sung, and Hannah Klein .......... 229
Structural and Functional Relationships of the XPF/MUS81
Family of Proteins
Alberto Ciccia, Neil McDonald, and Stephen C. West .......... 259
Fat and Beyond: The Diverse Biology of PPARγ
Peter Tontonoz and Bruce M. Spiegelman ...................... 289
Eukaryotic DNA Ligases: Structural and Functional Insights
Tom Ellenberger and Alan E. Tomkinson ....................... 313
Structure and Energetics of the Hydrogen-Bonded Backbone in
Protein Folding
D. Wayne Bolen and George D. Rose ........................... 339
Macromolecular Modeling with Rosetta
Rhiju Das and David Baker ................................... 363
Activity-Based Protein Profiling: From Enzyme Chemistry to
Proteomic Chemistry
Benjamin F. Cravatt, Aaron T. Wright,
and John W. Kozarich ........................................ 383
Analyzing Protein Interaction Networks Using Structural
Information
Christina Kiel, Pedro Beltrao, and Luis Serrano ............. 415
Integrating Diverse Data for Structure Determination of
Macromolecular Assemblies
Frank Alber, Friedrich Förster, Dmitry Korkin, Maya Topf,
and Andrej Sali ............................................. 443
From the Determination of Complex Reaction Mechanisms to
Systems Biology
John Ross ................................................... 479
Biochemistry and Physiology of Mammalian Secreted
Phospholipases A2
Gérard Lambeau and Michael H. Gelb .......................... 495
Glycosyltransferases: Structures, Functions, and Mechanisms
L.L. Lairson, B. Henrissat, G.J. Davies,
and S. G. Withers ........................................... 521
Structural Biology of the Tumor Suppressor p53
Andreas C. Joerger and Alan R. Fersht ....................... 557
Toward a Biomechanical Understanding of Whole Bacterial
Cells
Dylan M. Morris and Grant J. Jensen ......................... 583
How Does Synaptotagmin Trigger Neurotransmitter Release?
Edwin R. Chapman ............................................ 615
Protein Translocation Across the Bacterial Cytoplasmic
Membrane
Arnold J.M. Driessen and Nico Nouwen ........................ 643
Maturation of Iron-Sulfur Proteins in Eukaryotes:
Mechanisms, Connected Processes, and Diseases
Roland Lill and Ulrich Mühlenhoff ........................... 669
CFTR Function and Prospects for Therapy
John R. Riordan ............................................. 701
Aging and Survival: The Genetics of Life Span Extension by
Dietary Restriction
William Mair and Andrew Dillin .............................. 727
Cellular Defenses against Superoxide and Hydrogen Peroxide
James A. Imlay .............................................. 755
Toward a Control Theory Analysis of Aging
Michael P. Murphy and Linda Partridge ....................... 777
Indexes
Cumulative Index of Contributing Authors, Volumes 73-77 ....... 799
Cumulative Index of Chapter Titles, Volumes 73-77 ............. 803
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