List of Contributors ............................................ x
Foreword by Georg Nagel ....................................... xxi
Preface ....................................................... xxv
I Optogenetics in Model Organisms .............................. 1
1 Introduction to Optogenetics: From Neuronal Function to
Mapping and Disease Biology
Krishnarao Appasani and Raghu K. Appasani .................... 3
2 Uncovering Key Neurons for Manipulation in Mammals
Boris V. Zemelman ........................................... 18
3 From Connectome to Function: Using Optogenetics to Shed
Light on the Caenorhabditis elegans Nervous System
Koutarou D. Kimura and Karl Emanuel Busch ................... 37
4 From Synapse to Behavior: Optogenetic Tools for the
Investigation of the Caenorhabditis elegans Nervous System
Jatin Nagpal ................................................ 55
5 Using Optogenetics In Vivo to Stimulate Regeneration in
Xenopus laevis
Dany S. Adams, Ai-Sun Tseng, and Michael Levin .............. 66
II Opsin Biology, Tools, and Technology Platform .............. 77
6 Sodium and Engineered Potassium Light-Driven Pumps
Vitaly Shevchenko, Ivan Gushchin, Vitaly Poiovinkin,
Kirill Kovalev, Taras Balandin, Valentin Borshchevskiy,
and Valentin Gordeliy ....................................... 79
7 Methods for Simultaneous Electrophysiology and
Optogenetics In Vivo
Yonatan Katz and Ilan Lampl ................................. 93
8 Application of an Optogenetic Technique to a Study of
Activity-dependent Axon Growth in the Developing Cortex
Olga Malyshevskaya and Nobuhiko Yamamoto ................... 109
9 Development of an Optogenetic Tool to Regulate Protein
Stability In Vivo
Christian Renicke and Christof Taxis ....................... 118
10 Photoactivatable Nucleotide Cyclases for Synthetic
Photobiology Applications
Marc Folcher ............................................... 132
11 Bioluminescence Activation of Light-sensing Molecules
Ute Hochgeschwender ........................................ 151
III Optogenetics in Neurobiology, Brain Circuits, and
Plasticity .................................................... 167
12 Optogenetics for Neurological Disorders: What Is the Path
to the Clinic?
William F. Kaemmerer ....................................... 169
13 Optogenetic Control of Astroglia
Anja G. Teschemacher and Sergey Kasparov ................... 181
14 Optogenetics for Neurohormones and Neuropeptides: Focus
on Oxytocin
Yan Tang, Jérôme Wahis, Meggane Melchior, Valery
Grinevich, and Alexandre Charlet ........................... 196
15 Optogenetic Approaches to Investigating Brain Circuits
Alexander M. Herman, Jay M. Patel, and Benjamin
R. Arenkiel ................................................ 206
16 Optogenetic Mapping of Neuronal Connections and their
Plasticity
Michael M. Kohl and Dennis Kätzel .......................... 224
IV Optogenetics in Learning, Neuropsychiatric Diseases, and
Behavior ................................................... 239
17 Optogenetics to Study Reward Learning and Addiction
Andrea L. Gutman and Ryan T. LaLumiere ..................... 241
18 Optogenetics and the Dissection of Neural Circuits
Underlying Depression and Substance-use Disorders
Barbara Juarez, Allyson K. Friedman, and Ming-Hu Han ....... 257
19 Optogenetics Research in Behavioral Neuroscience:
Insights into the Brain Basis of Reward Learning and
Goal-directed Behavior
Adam C.G. Crego, Stephen E. Chang, William N. Butler,
and Kyle S. Smith .......................................... 276
20 Toward an Optogenetic Therapy for Epilepsy
Jan Tønnesen, Marco Ledri, and Merab Kokaia ................ 292
21 Using Optogenetics and Stem Cell-derived Neural
Engraftment Techniques to Restore Lost Motor Function
J. Barney Bryson and Linda Greensmith ...................... 308
V Optogenetics in Vision Restoration and Memory .............. 325
22 Optogenetics in Treating Retinal Disease
Dasha Nelidova and Federico Esposti ........................ 327
23 Optogenetics for Vision Recovery: From Traditional to
Designer Optogenetic Tools
Sonja Kleinlogel ........................................... 337
24 А Promise of Vision Restoration
Grégory Gauvain, Antoine Chaffiol, Jens Duebel, and
Serge A. Picaud ............................................ 356
25 Holographic Optical Neural Interfacing with Retinal Neurons
Adi Schejter Bar-Noam, Inna Gefen, and Shy Shoham .......... 371
26 Strategies for Restoring Vision by Transducing
a Channelrhodopsin Gene into Retinal Ganglion Cells
Hiroshi Tomita and Eriko Sugano ............................ 382
27 Optogenetic Dissection of a Top-down Prefrontal to
Hippocampus Memory Circuit
Priyamvada Rajasethupathy .................................. 393
VI Optogenetics in Sleep, Prosthetics, and Epigenetics of
Neurodegenerative Diseases .................................... 405
28 Optogenetic Dissection of Sleep-Wake Control: Evidence
for a Thalamic Control of Sleep Architecture
Charles-Francois Vincent Latchoumane and Hee-Sup Shin ...... 407
29 Optogenetics and Auditory Implants
Jenny X. Chen, Elliott Kozin, M. Christian Brown, and
Daniel J. Lee .............................................. 421
30 Optogenetic Stimulation for Cochlear Prosthetics
Victor H. Hernandez Gonzalez and Tobias Moser .............. 442
31 The Role of Amino Acids in Neurodegenerative and
Addictive Diseases
Joan Fallon ................................................ 453
32 Optogenetics in Deep Brain Stimulation: Ethical
Considerations
Sabine Müller and Henrik Walter ............................ 463
Index ......................................................... 470
The color plates are to be found between pages 324 and 325
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