Foreword ........................................................ v
About the Editor .............................................. vii
List of Contributors ........................................... ix
Section I. General Introduction to Inflammation and Cancer in
the Digestive Tract
Ming Xing Li and Chi Hin Cho ................................. 1
Section II. Inflammation and Therapeutics in the Digestive
Tract ........................................................... 5
Chapter 1 Brain-Gut Relationship on Mucosal Inflammation in
the Gastrointestinal Tract ........................... 7
Klara Gyires and Agnes Fehér
Chapter 2 Nesfatin-1: The Novel Appetite Peptide with
Therapeutic Efficacy to Prevent Acute Hemorrhagic
Gastric Lesions and Accelerate Gastric Ulcer
Healing ............................................. 33
Alehandra Szlachcic, Jolanta Majka, and Tomasz
Brzozowski
Chapter 3 Chemoprophylaxis in Inflammatory Bowel Disease ...... 57
Nikola Mitrev, Aladdin Alswaifi, and Rupert W. Leong
Chapter 4 Targeting the Nuclear Receptor HNF4α as a Potential
Therapy for Gut Inflammation and Cancer ............. 77
Jean-Philippe Babeu and François Boudreau
Chapter 5 EstabЬshed Therapies and New Therapeutic Strategies
in AlcohoHc Liver Disease ........................... 99
Helmut Karl Seitz and Sebastian Mueller
Section III. Carcinogenesis and Therapeutic Targets
in the Gastrointestinal Tract ................................. 129
Chapter 6 Targets of Tumor Epigenetics and Its
Microenvironment in Gastrointestinal Cancer ........ 131
Ssu-Yin Yen, Hong-Meng Chuang Mao-Hsuan Huang,
Sheng-Feng Tsai, Tzyy-Wen Chiou, Hong-Lin Su,
Li-Ing Ho, Shinn-Zong Lin, and Horng-Jyh Harn
Chapter 7 Esophageal Cancer: From Bench to Bedside ........... 151
Gang Ma and Zhihua Liu
Chapter 8 Angiogenesis and Lymphangiogenesis in Gastric MALT
Lymphoma: Relation of VEGF and VASH2 ............... 177
Masahiko Nakamura, Anders Øverby, and Hidenori
Matsui
Chapter 9 NF-kB as a Potential Molecular Target for Therapy
of Gastrointestinal Cancers ........................ 189
Nathan Palmer, Muthu К. Shanmugam, Gautam Sethi,
and Philipp Kaldis
Chapter 10 Hypoxia-Inducible Factor-1α Modulation in
Colorectal Carcinogenesis .......................... 213
Francesco Mariani, Stefano Mancini, Paola Sena,
and Luca Roncucci
Chapter 11 Therapeutic Approaches Targeting the Serrated
Pathway of Colorectal Cancer Characterized by
Mutation in the BRAF Gene and Overexpression of
GTPase Raclb ....................................... 233
Paulo Matos, Vânia Gonçalves, and Peter Jordan
Chapter 12 The "Yin" and "Yang" of Target-Oriented
Anticancer Phytochemicals Derived from Herbal
Medicines .......................................... 257
Cathy K. Auyeung and Joshua K.S. Ко
Chapter 13 The Degradation System of Prostaglandin in
Gastrointestinal Cancer ............................ 281
Tetsuya Tanigawa, Toshio Watanabe, Shogo Takeda,
Hiroshi Tatsuwaki, Masatsugu Shiba, Kazunari
Tominaga, Yasuhiro Fujiwara, and Tetsuo Arakawa
Chapter 14 Prostaglandin and Its Receptors: Potential
Targets for Gastrointestinal Inflammation and
Cancer ............................................. 295
Vivian Y. Shin and Ava Kwong
Section IV. Autophagy and microRNAs as the Therapeutic
Targets in Gastrointestinal Cancers ........................... 309
Chapter 15 Modulation of Autophagy as a Potential
Therapeutic Target for Gastrointestinal Cancers:
Promises and Uncertainties ......................... 311
Li Ma
Chapter 16 microRNAs as Therapeutic Targets for Gastric
Cancer ............................................. 343
Takatsugu Ishimoto and Hideo Baba
Chapter 17 microRNA-based Novel Therapeutic Development in
Gastrointestinal Cancer ............................ 365
Andrew Fester and Jingfang Ju
Chapter 18 Unraveling the Relationship between Autophagy
and microRNA in Gastrointestinal Cancer ............ 387
Yuanyuan Yin, Peiqi Wang Yaxin Zheng Yi Chen,
and Jinhui Wang
Index ......................................................... 421
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