Contributors .................................................. vii
Prologue ....................................................... xi
Abbreviations ................................................ xiii
PART I: Homeostatic Regulators: Molecules and Ions
1 Microdynamics of Water and Ion Homeostasis in the Brain:
Role of Aquaporins and Ion Channels of Astroglial Cells ...... 3
VALENTINA BENFENATI AND STEFANO FERRONI
2 Homeostatic Control of Adenosine Levels and Functions in
the Brain ................................................... 31
XUESONG CHEN, MAHMOUD L. SOLIMAN, LIANG HUI, AND JONATHAN
D. GEIGER
3 Glutamate Homeostasis as a Regulator of Neurotransmitter
Recycling and Synaptic Function ............................. 44
MARY ELLEN KELLY AND DOUGLAS A. COULTER
4 Homeostasis of Neuronal Excitability Via Synaptic and
Intrinsic Inhibitory Mechanisms ............................. 51
JOCHEN MEIER, MARCUS SEMTNER, AND JAKOB WOLFART
PART II: Homeostatic Control: Systems and Cells
5 Role of Astrocytes in Sleep and Epilepsy .................... 75
JEROME CLASADONTE AND PHILIP G. HAYDON
6 Astrocyte-Neuron Interactions ............................... 98
ANGUS M. BROWN AND BRUCE R. RANSOM
7 Homeostatic Synaptic Scaling at Central Synapses ........... 108
NIRAJ S. DESAI AND ELISABETH C. WALCOTT
8 Homeostatic Role of Heterosynaptic Plasticity .............. 124
NICHOLAS M. BANNON, MARINA CHISTIAKOVA, AND MAXIM VOLGUSHEV
9 The Blood-Brain Barrier .................................... 143
YONATAN SERLIN, ALON FRIEDMAN, AND UWE HEINEMANN
10 Inflammation and Immunomodulation in Epilepsy and Its
Comorbidities .............................................. 155
ANDREY MAZARATI AND ANNAMARIA VEZZANI
11 Neuroplasticity ............................................ 175
HIROYUKI OKUNO
12 Epigenetics ................................................ 187
KATJA KOBOW AND INGMAR BLÜMCKE
13 Adult Neural Stem Cells and Brain Homeostasis .............. 202
ASHOK K. SHETTY
PART III: Homeostatic Manipulators: Preventative and
Restorative Opportunities
14 Systems (Network) Pharmacology for Brain Functionality
Restoration ................................................ 231
DORU GEORG MARGINEANU
15 Ketogenic Diets for Neurological Disorders .................
LINDSEY B GANO, MANISHA PATEL, AND JONG M. RHO
16 Dietary Manipulations ...................................... 271
ATHANASIUS EVANGELIOU AND MARTHA SPILIOTI
17 Exercise ................................................... 298
MARKUS DWORAK
18 Sleep ...................................................... 314
KRISTINA SIMEONE, CHAZ JOHNSON, KAELI SAMSON, HARRISON
ROUNDTREE, TIM SIMEONE, AND LEILA TAROKH
19 Botanicals ................................................. 333
DANA EKSTEIN AND STEVEN C. SCHACHTER
20 The Role of Acupuncture in Nociception Homeostasis ......... 341
NANNA GOLDMAN, TAKAHIRO TAKANO, BENJAMIN T. KRESS, AND
MAIKEN NEDERGAARD
21 Meditation ................................................. 353
GAËLLE DESBORDES
22 Neurotrophic Regulation in Neurorestoration of the Brain ... 371
CAIXIN SU, MICHEL RATHBONE, AND SHUCUI JIANG
PART IV: Homeostatic Therapies for Disease and Dysfunction
23 Epilepsy ................................................... 401
DETLEV BOISON
24 Traumatic Brain Injury ..................................... 420
RAJ G. KUMAR AND AMY K. WAGNER
25 Adenosine and Alzheimer's Disease: A Possible Epigenetic
Link ....................................................... 453
DAVID BLUM, URSULA S. SANDAU, OLIVIER BOUSIGES, LUISA
V. LOPES, VANESSA FLATEN, EMILIE FAIVRE, LUC BUËE,
ANNE-LAURENCE BOUTILLIER, AND DETLEV BOISON
26 Brain Homeostasis and Parkinson's Disease .................. 481
DEEPTI LALL
27 Brain Homeostasis and Addiction ............................ 509
LETISHA R. WYATT
28 Anxiety and Stress Disorders ............................... 535
EVA MARIA MARCO AND MARIA-PAZ VIVEROS
29 Malignant Brain Cancer Management with Metabolic Therapy ... 553
THOMAS N SEYFRIED AND PURNA MUKHERJEE
30 Obesity and Diabetes: Nature, Nurture, and Beyond .......... 570
CHARLES MOBBS
31 Autism Spectrum Disorder and Homeostasis ................... 586
SUSAN A MASINO, JESSICA A. FORTIN, MICHELLE I. MURPHY,
LISA SAA, AND DAVID N. RUSKIN
Index ......................................................... 611
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