SMALL MOLECULE AGONISTS OF RELAXIN RECEPTOR
   A.I. Agoulnik, I.U. Agoulnik, X. Hu, C. Myhr, Z. Huang,
   B.A. Ho, E. Barnaeva, J. Xiao, M. Ferrer, N.T. Southall,
   J.J. Marugan ................................................ 25
THE ROLE OF FUNCTIONAL DOMAINS OF DROSOPHILA SEPTIN PNUT
   K.A. Akhmetova, N.V. Dorogova, M.L. Balasov, S.A. Fedorova,
   I.N. Chesnokov .............................................. 26
A FUNCTIONAL ANALYSIS OF SEPTIN PROTEINS IN DROSOPHILA 
MELANOGASTER S2 CELLS
   A.L. Alekseeva, E.N. Andreyeva, L.A. Yarinich, A.V. 
   Pindyurin, S.A. Fedorova .................................... 27
APPROACH TO PREDICTING THE SOLUBILITY/INSOLUBILITY OF E. COLI 
PROTEINS BASED ON THEIR PRIMARY STRUCTURE USING SEQUENCE 
NORMALIZATION AND MACHINE LEARNING TECHNIQUES
   N.A. Alemasov, N.V. Ivanisenko, K.S. Antonets, 
   A.A. Nizhnikov, V.A. Ivanisenko ............................. 28
THE FUNCTIONAL INTERACTIONS OF PLEIOTROPIC PROTEIN YB-1 WITH 
KEY BASE EXCISION REPAIR FACTORS
   E.E. Alemasova, N.A. Moor, K.N. Naumenko, P.E. Pestryakov, 
   O.I. Lavrik ................................................. 29
THE P53 FAMILY IN CANCER BIOLOGY
   I. Amelio, F. Bernassola, T.W. Mak, G. Melino ............... 30
CHANGE OF THE SCENARIO OF THE TRP-CAGE MINIPROTEIN FOLDING 
WITH TEMPERATURE
   V.A. Andryushchenko, S.F. Chekmarev ......................... 31
AGING AND CANCER: STATE-OF-ART AND PROSPECTS FOR PREVENTION
   V.N. Anisimov ............................................... 32
vlincRNA DATABASE: TOOL FOR VERY LONG INTERGENIC NON-CODING 
RNA FUNCTIONAL ANNOTATION
   D. Antonets, Y. Vyatkin, D. Luppov, P. Kapranov, M. Ri, 
   O. Saik, D. Shtokalo ........................................ 33
POXVIRAL CHEMOKINE-BINDING PROTEINS: THEORETICAL STUDY OF 
STRUCTURE AND FUNCTION EVOLUTION
   D.V. Antonets, K.V. Gunbin, T.S. Nepomnyashchikh ............ 34
TRANSCRIPTOME WIDE PREDICTION OF LNCRNA-RNA INTERACTIONS BY 
A THERMODYNAMICS ALGORITHM
   I.V. Antonov, M.A. Zamkova, A.V. Marakhonov, M.Y. Skoblov,
   Y.A. Medvedeva .............................................. 35
DIFFERENTIAL ALTERNATIVE SPLICING IN RATS BRAIN TISSUES 
SELECTED BY AGGRESSIVE BEHAVIOUR
   V.N. Babenko, A.O. Bragin, I.V. Chadaeva, Y.L. Orlov ........ 36
MOLECULAR MODELING OF INFLUENZA VIRUS H1N1 HEMAGGLUTININ 
INHIBITION BY CAMPHOR IMINES
   D.S. Baev, A.S. Sokolova, O.I. Yarovaya, T.G. Tolstikova,
   V.V. Zarubaev ............................................... 37
THE USE OF DISCIMINANT ANALYSIS AND ARTIFICIAL NEURONAL 
NETWORK IN BREAST CANCER DETECTION
   U.S. Bagina, L.V. Shchegoleva, T.O. Volkova ................. 38
De novo sequencing and comparative analysis of chloroplast 
genomes for four ferns of Dryopteris and Adiantum genera
   M.S. Belenikin, A.A. Krinitsina, S.V. Kuptsov, 
   M.D. Logacheva, A.S. Speranskaya ............................ 39
EVOLUTION OF RESTRICTION-MODIFICATION SYSTEMS IN LARGE SCALE
   O.I. Bezsudnova, I.S. Rusinov, A.S. Ershova, 
   A.S. Karyagina, S.A. Spirin, A.V. Alexeevski ................ 40
HOW TO ACCOMPLISH A RAPID DEFENSE AGAINST FOREIGN DNA – 
RESTRICTIONMODIFICATION SYSTEMS AND IMPLICATIONS FOR 
SYNTHETIC GENE CIRCUITS
   B. Blagojevic, M. Djordjevic, M. Djordjevic ................. 41
STATISTICS OF INTERVALS BETWEEN SIMILAR MONOMERS: 
A COMPLEMENTARY WAY TO ASSESS THE STRUCTURAL PROPERTIES OF
BIOLOGICAL POLYMERS
   M.I. Bogachev, A.R. Kayumov, O.A. Markelov .................. 42
HUMAN AUTHENTICATION USING ELECTROCARDIOGRAM
   M.R. Bogdanov ............................................... 43
INTERSPERSED REPETITIVE SEQUENCES DISTRIBUTION IN HUMAN 
CHROMOSOMES ANALYZED BY IN SITU HYBRIDIZATION AND IN SILICO
ANALYSIS
   A.G. Bogomolov, T.V. Karamysheva, N.B. Rubtsov .............. 44
THE SOFTWARE FOR ESTIMATION OF TELOMERE LENGTH ON 
INDIVIDUAL CHROMOSOME ARMS IN IMMUNOPATHOLOGY
   A.G. Bogomolov, M.S. Barkovskaya, N.B. Rubtsov, 
   V.A. Kozlov ................................................. 45
RIBOSOMAL GENES AS PHYLOGENETIC MARKERS FOR STUDING 
EVOLUTION OF BLUE-FLOWERED FLAXES
   N.L. Bolsheva, N.V. Melnikova, A.A. Dmitriev,
   M.S. Belenikin, A.S. Speranskay, A.A. Krinitsina,
   G.S. Krasnov, V.A. Lakunina, A.V. Snezhkina, 
   A.F. Sadritdinova, T.A. Rozhmina, A.V. Amosova,
   T.E. Samatadze, O.Yu. Yurkevich, N.G. Shostak, 
   S.A. Zoshchuk, A.V. Kudryavtseva, O.V. Muravenko ............ 46
SIBERIAN LARCH CHLOROPLAST GENOME ANALYSIS OVER TRIPLET 
FREQUENCY DISTRIBUTION
   E.I. Bondar, Y.A. Putintseva, K.V. Krutovsky ................ 47
THE OPPOSING EFFECTS OF SHORT- AND LONG-TERM SOCIAL STRESS ON 
PREFRONTAL CORTEX TRANSCRIPTOME
   N.P. Bondar, L.O. Bryzgalov, N.E. Ershov, F.E. Gusev, 
   V.V. Reshetnikov, D.F. Avgustinovich, M.V. Tenditnik, 
   E.I. Rogaev, T.I. Merkulova ................................. 48
RNA-SEQ DATA ANALYSIS OF RATS WITH AGGRESSIVE BEHAVIOR IN 
THREE BRAIN AREAS
   A.O. Bragin, A.L. Markel, V.N. Babenko, I.V. Chadaeva, 
   E.S. Tiys, Y.L. Orlov ....................................... 49
ИСПОЛЬЗОВАНИЕ МИКРОФЛЮИДИКИ DOLOMITE ДЛЯ СЕКВЕНИРОВАНИЯ 
ТРАНСКРИПТОМОВ ОТДЕЛЬНЫХ КЛЕТОК
   D. Brittal .................................................. 50
DELINEATING SINGLE CELL LIFE/DEATH DECISIONS IN THE CD95/FAS
NETWORK
   J.H. Buchbinder, D. Pischel, K. Sundmacher, R.J. Flassig, 
   I.N. Lavrik ................................................. 51
MODELING OF TWO PHASEs IN DROSOPHILA SENSORY ORGAN 
PRECURSOR cell DETERMINATION
   T.A. Bukharina, D.P. Furman, V.P. Golubyatnikov, 
   M.V. Kazantsev .............................................. 52
NUMERICAL MODEL OF DROSOPHILA SENSORY ORGAN PRECURSOR CELL
DETERMINATION
   T.A. Bukharina, D.P. Furman, V.P. Golubyatnikov, 
   M.V. Kazantsev .............................................. 53
EVOLUTION FEATURES OF THE THREE CODON POSITIONS IN GENE OF 
ENVELOP PROTEIN E FOR DIFFERENT GENOTYPES OF THE TICK-BORNE 
ENCEPHALITIS VIRUS
   Yu.S. Bukin, Yu.P. Dzhioev, I.V. Kozlova, S.E. Tkachev, 
   D.O. Kiselev, A.I. Paramonov, O.N. Reva, V.I. Zlobin ........ 54
STOCHASTIC MODEL OF SPECIATION, WHICH DESCRIBES THE 
EVOLUTIONARY BRANCHING PROCESS WITHIN THE SPECIES FLOCK IN 
A CLOSED ECOSYSTEM
   Yu.S. Bukin, D.Yu. Sherbakov ................................ 55
ONLINE SCRIPTING TOOL FOR RETRIEVING 3D HUMAN GENOME DATA
   A. Butyaev, J. Waldispьh .................................... 56
UGENE: A TOOLKIT FOR TEACHING STUDENTS
   I.V. Bykova, O.I. Golosova, A.Y. Bakulina, D.A. Afonnikov,
   D.Y. Kandrov, A.Y. Palyanov, G.A. Grekhov, Y.E. Danilova .... 57
GENE ONTOLOGY ANALYSIS AND NETWORK RECONSTRUCTION FOR GENES
RELATED TO AGING DISEASES AND BEHAVIOR
   I.V. Chadaeva, O.V. Saik, V.N. Babenko ...................... 58
ANTIOXIDANT RESPONSE ELEMENT CONTROLS LYSOSOMAL BIOGENESIS 
MASTER-REGULATOR GENES
   A.V. Chechushkov, N.K. Zenkov, E.B. Menshchikova ............ 59
SOFTWARE MODULE FOR INTEGRATION OF SBML-WRITTEN MATHEMATICAL 
MODELS OF MOLECULAR GENETIC SYSTEMS FOR THE HAPLOID 
EVOLUTIONARY CONSTRUCTOR 3D SOFTWARE PACKAGE
   A.D. Chekantsev, S.A. Lashin ................................ 60
A SPATIAL MODEL OF PLANT INTERACTOME AND LONG NON-CODING RNA
   M. Chen ..................................................... 61
LONG-TERM SPACEFLIGHT MEDIATED CHANGES IN PROMOTER LANDSCAPE
IN ZEBRAFISH TISSUES
   A.V. Cherkasov, K.V. Arshavsky, V.N. Sychev, 
   M.A. Levinskikh, O.A. Gusev ................................. 62
SIMULATION OF ENHANCER EVOLUTION IN A COMPUTATIONAL MODEL
OF THE DROSOPHILA GAP GENE NETWORK
   A.A. Chertkova, J. Schiffman, K.N. Kozlov, M.G. Samsonova,
   S.V. Nuzhdin, V.V. Gursky ................................... 63
FUNCTIONAL ANALYSES ON THE MECHANISM OF INDUCTION OF 
ANHYDROBIOSIS IN THE MIDGE Polypedilum vanderplanki
   R. Cornette, K-I. Iwata, S. Kikuta, Y. Sogame, T. Okuda,
   T. Kikawada ................................................. 64
MODELING OF THE BLOOD FLOW IN THE NARROWED VESSELS
   S.G. Davydova, E.A. Biberdorf ............................... 65
STRUCTURAL PATTERNS AMONG THE DIVERSITY OF FLAVIN-DEPENDENT
OXIDOREDUCTASES FROM LUMINOUS BACTERIA AND E. COLI
   A.A. Deeva, E.A. Temlyakova, A.A. Sorokin, E.V. Nemtseva,
   V.A. Kratasyuk .............................................. 66
ANHYDROBIOSIS RELATED PROMOTERS IN PV11 CELL LINE
   R.M. Deviatiiarov, T. Kikawada, R. Cornette, O.A. Gusev ..... 67
GENE EXPRESSION PROFILING OF FLAX (LINUM USITATISSIMUM L.)
UNDER EDAPHIC STRESS
   A.A. Dmitriev, A.V. Kudryavtseva, N.V. Koroban, 
   G.S. Krasnov, A.S. Speranskaya, A.A. Krinitsina,
   M.S. Belenikin, A.V. Snezhkina, A.F. Sadritdinova, 
   O.Yu. Yurkevich, N.V. Kishlyan, T.A. Rozhmina,
   O.V. Muravenko, N.L. Bolsheva, N.V. Melnikova ............... 68
GENETICS AND PHYSIOLOGY OF WHEAT INFLORESCENCE DEVELOPMENT
   O.B. Dobrovolskaya, P. Martinek, Yu.L. Orlov, 
   A.A. Krasnikov, E.D. Badaeva, K.I. Popova, J. Salse, 
   N. Watanabe ................................................. 69
THE MANIFESTATION AND PHYTOHORMONE RESPONCE OF LEAF 
PUBESCENCE GENES IN BREAD WHEAT
   A.V. Doroshkov, A.V. Simonov, D.A. Afonnikov, 
   T.A. Pshenichnikova ......................................... 70
A SOFTWARE SYSTEM FOR SIMULATING SOCIAL AND GENETIC
ASPECTS OF DEAFNESS IN HUMAN POPULATIONS
   I.S. Dyachenko, O.L. Posukh, M.S. Bady-Khoo, M.V. Zytsar, 
   V.Yu. Mikhalskaia, G.P. Romanov, N.A. Barashkov, 
   Yu.G. Matushkin, S.A. Lashin ................................ 71
SOME ASPECTS OF MOLECULAR EVOLUTION AND RECOMBINATIONAL 
VARIABILITY OF THE ZIKA VIRUS
   Y.P. Dzhioev, A.I. Paramonov, Y.S. Bukin, I.V. Kozlova, 
   V.I. Zlobin ................................................. 72
THE DISTANCE MATRIX BOOTSTRAPPING IN THE CASE OF 
QUANTITATIVE TRAITS
   V.M. Efimov, K.V. Efimov, V.Y. Kovaleva ..................... 73
METABOLITE PROFILING OF THE MOSS PHYSCOMITRELLA PATENS
INOCULATED WITH PSEUDOMONAS
   E.D. Egorova, N.A. Baraeva, S.V. Vinogradova ................ 74
DYNAMIC RECOGNITION OF 8-OXOGUANINE BY DIFFERENT PROTEIN 
FOLDS
   A.V. Endutkin, C. Simmerling, D.O. Zharkov .................. 75
AGEING OF MULTICELLULAR ORGANISMS AS A STAGE OF ONTOGENESIS
   I.L. Erokhin ................................................ 76
OPISTHORCHIIDAE TRIAD: COMPARATIVE GENOMICS OF THE 
CARCINOGENIC LIVER FLUKES USING A DRAFT GENOME OF 
OPISTHORCHIS FELINEUS
   N. Ershov, G. Fan, E. Prokhortchouk, V. Solovyev,
   D. Afonnikov, H. Yang, V. Mordvinov, X. Liu, K. Skryabin .... 77
ELUCIDATION OF MOLECULAR SIGNAL OF TRANSCRIPTION RESPONSE TO
DESICCATION STRESS IN CHIRONOMID P. VANDERPLANKI
   E.I. Shagimardanova, R.M. Deviatiyarov, T. Kikawada, 
   O.A. Gusev .................................................. 78
STRUCTURAL BASIS FOR THE RECOGNITION AND PROCESSING OF DNA 
CONTAINING BULKY LESIONS BY THE MAMMALIAN NUCLEOTIDE 
EXCISION REPAIR SYSTEM
   A. Evdokimov, A. Popov, I. Petruseva, O. Lavrik ............. 79
PRINCIPAL ORGANIZATION OF PHYSIOLOGICAL REGULATOR
   V.I. Fedorov ................................................ 80
PHYLOGENY DEVELOPED OVER THE TRIPLET COMPOSITION OF 
MITOCHONDRIAL GENOMES: HIGH SYNCHRONY IN THE EVOLUTION OF 
TWO GENETIC SYSTEMS
   V.S. Fedotova, M.G. Sadovsky, Yu.A. Putintseva .............. 81
INTEGRATION OF TRANSCRIPTOMIC AND PROTEOMIC DATA TO ELUCIDATE
THE MECHANISM OF ACTION OF NOVEL COMPOUNDS: THE CASE OF THE 
ANTITUMOR PEPTIDE CIGB552
   J.R.F. Massу, T.N. de Villavicencio-Dнaz, Y.R. Gуmez, 
   B.O. Argьelles, A.R. Ulloa, Y.C. Garcнa, O.G. Cruz, 
   Y.P. Riverol, L.J. Gonzбlez, I. TiscorniaI, S. Victoria, 
   M.B. Fogolнn, V.B. Pйrez, L.D. Roche, D.P. Gardon, 
   I.G. Perez, D.V. Blomquist, L.N. Perez, Y.G. Rodriguez, 
   M.G. Vallespi ............................................... 82
THE SPATIAL MAP OF AVIAN GENOME
   V. Fishman, N. Battulin, A. Maslova, O. Serov, 
   A. Krasikova ................................................ 83
A NEW ALGORITHM TO THE RECONSTRUCTION OF A SET OF POINTS FROM
THE MULTISET OF N2 PAIRWISE DISTANCES IN N2
STEPS FOR THE DE NOVO SEQUENCING PROBLEM
   E.S. Fomin .................................................. 84
MOLECULAR MODELING OF THE INTERACTION BETWEEN INDOLE LUPANE 
DERIVATIVES AND C-MYC/MAX HETERODIMER
   T.S. Frolova, D.S. Baev, A.V. Petrova, E.K. Khusnutdinova, 
   O.I. Sinitsyna .............................................. 85
ALTERED CATECHOLAMINERGIC, SEROTONERGIC, GABAERGICS, AND
GLUTAMATERGIC GENES EXPRESSION IN THE VENTRAL TEGMENTAL AREA 
OF MALE MICE UNDER CHRONIC SOCIAL DEFEAT STRESS: RNA-SEQ DATA
   A.G. Galyamina, I.L. Kovalenko, D.A. Smagin, 
   N.N. Kudryavtseva ........................................... 86
RECONSTRUCTION OF TRANSCRIPTION CONTROL NETWORK IN 
GENOME-REDUCED BACTERIA BY HIGH-THROUGHPUT PROMOTERS
IDENTIFICATION
   I.A. Garanina, G.U. Fisunov, D.V. Evsutina, V.M. Govorun .... 87
GENOME-WIDE TRANSCRIPTOMICS AS A PLATFORM FOR UNDERSTANDING 
THE UNUSUAL RESISTANCE TO MUSCLE ATROPHY IN HIBERNATING 
DORMICE
   G.R. Gazizova, O.V. Tyapkina, O.S. Kozlova, 
   M.D. Logacheva, L.F. Nurullin, I.M. Vikhlyantsev, 
   O.A. Gusev .................................................. 88
SYSTEMIC RESPONSE TO GENETIC AND CHEMICAL MODULATION OF 
DDR REGULATING WILD TYPE P53-INDUCED PHOSPHATASE IN SKIN, 
INTESTINE AND HEMATOPOIETIC SYSTEM
   A.R. Goloudina, B.B. Grigorash, E.Y. Kochetkova, 
   E. Appella, V.A. Pospelov, O.N. Demidov ..................... 89
PREDICTING OF THERMODYNAMIC DATA OF MORPHOLINO ANALOGOUS OF 
NA BY COMPUTER APPROACH AND COMPARING WITH EXPERIMENTS
   V.M. Golyshev, A.A. Lomzov .................................. 90
TUMOR-SPECIFIC CELL FREE DNA AS A BIOMARKER OF METASTASIS
   T.M. Gorbacheva, S.A. Solodskikh, V.Yu. Bashmakov, 
   V.Yu. Panevina, A.Y. Maslov, V.N. Popov ..................... 91
DNA DAMAGE INITIATING DEMETHYLATION: A REPAIR–EPIGENETIC 
CONNECTION
   I.R. Grin, A.A. Ishchenko ................................... 92
CONSERVATION LEVEL OF THE KEY MEIOTIC PROTEINS REFLECTS 
THEIR FUNCTION AND INDEPENDENT EVOLUTION IN DIFFERENT 
LINEAGES OF EUKARYOTES
   T.M. Grishaeva, Yu.F. Bogdanov .............................. 93
A COMPUTATION SYSTEM FOR RANDOMIZATION-BASED ENRICHMENT 
ANALYSIS USING GPU: PERFORMANCE INVESTIGATION
   M. Grishenko, A. Yakimenko, M. Khairetdinov, K. Gunbin ...... 94
ACTIVE MAINTENANCE OF PHYLOTRANSCRIPTOMIC HOURGLASS PATTERNS 
IN PLANT AND ANIMAL EMBRYOGENESIS
   H.-G. Drost, A. Gabel, I. Grosse, M. Quint .................. 95
SEARCHING FOR CYTOLYTIC GENETIC MARKERS OF NEWCASTLE DISEASE 
VIRUS USING COMPUTER ASSISTED ANALYSIS
   K.V. Gunbin, M.R. Kabilov, K.S. Yurchenko,
   A.V. Glushchenko, A.M. Shestopalov, N.V. Gubanova ........... 96
TRANSCRIPTOMIC ANALYSIS OF WHEAT ROOT IN RESPONSE TO 
ESSENTIAL NUTRIENT DEFICIENCY: A GEMOME-WIDE COMPARATIVE STUDY
   S. Gupta, B.S. Yadav, S. Freilich, P.K. Varadwaj ............ 97
TRANSCRIPTION BY ALTERNATIVE SIGMA FACTORS: REVISING THE
RIGIDNESS PARADIGM
   J. Guzina, M. Djordjevic .................................... 98
SCORING OF PROTEIN DOCKING BY GENE ONTOLOGY
   A. Hadarovich, I. Anishchenko, A.V. Tuzikov, 
   P.J. Kundrotas, I.A. Vakser ................................. 99
KATIS: INTEGRATIVE INFORMATION SYSTEM FOR COMPLEMENTARY 
MEDICINE
   R. Hofestдdt, V. Ogultarhan, A. Shoshi ..................... 100
LONG NON-CODING RNAS IN FANTOM5
   C.-C. Hon, J.A. Ramilowski, Y. Hayashizaki, P. Carninci, 
   A. Forrest ................................................. 101
IDENTIFICATION OF NEW CANDIDATE GENES FOR ELEVATED BODY MASS
INDEX NEAR GWAS SNPs USING TRANSCRIPT ANNOTATIONS FROM 
ENSEMBL AND HAVANA PROJECTS
   E.V. Ignatieva, V.G. Levitsky .............................. 102
THE COMPENDIUM OF HUMAN GENES CONTROLLING FEEDING BEHAVIOR 
OR BODY WEIGHT, RECONSTRUCTION OF NETWORKS AND ANALYSIS OF 
THEIR PROPERTIES
   E.V. Ignatieva, O.V. Saik, D.A. Afonnikov .................. 103
SYNTHESIS AND ACCUMuLATION OF A NOVEL FUNCTIONAL FOOD 
COMPONENT IN TOMATO
   A. Ito, S. Hano, N. Imoto, T. Shibuya, Y. Kanayama ......... 104
NOVEL APPROACH FOR COMPUTATIONAL DESIGN OF SMALL MOLECULE 
INHIBITORS OF PROTEIN/PROTEIN INTERACTIONS IN CD95/FAS 
PATHWAY
   N.V. Ivanisenko, A.S. Ishchenko, I.N. Lavrik, 
   V.A. Ivanisenko ............................................ 105
POLYMORPHISM OF LOXLI GENE IN WEST SIBERIA PATIENTS WITH 
OPEN ANGLE GLAUCOMAAND PSEUDOEXFOLIATION GLAUCOMA.
   D.E. Ivanoshchuk, E.O. Datskih, N.A. Konovalova, 
   I.Y. Bychkov, A.Z. Fursova, O.S. Konovalova, 
   S.V. Mikhailova , M.N. Ponomareva, M.I. Voevoda,
   A.G. Romaschenko ........................................... 105
IDENTIFICATION OF PROTEINS ASSOCIATED WITH DRUG-INDUCED 
LIVER INJURY USING IN SILICO PREDICTION OF DRUG-TARGET 
INTERACTIONS
   S.M. Ivanov, M.I. Semin, A.A. Lagunin, D.A. Filimonov,
   V.V. Poroikov .............................................. 106
USING THE BIOINFORMATIC SOFTWARE: TECIINICIIES TO SEARCH 
CRISPR /CAS SYSTEMS IN THE GENOME OF ESCHERICHIA COL1 STRAIN
0157
   E.I. Ivanova, Yu.P. Dzhioev, A.Yu. Borisenko, 
   A.I. Paramonov, V.I. Zlobin, N.L. Belkova .................. 107
miR-619-5p BINDING SITES IN PROTEIN CODING REGION OF
ORTHOLOG GENES mRNA
   A.T. Ivashchenko, S.A. Atambayeva, R.E. Niyazova, 
   A.Y. Pyrkova ............................................... 108
FEATURES OF miRNA INTERACTION WITH mRNA GENES IN CORONARY 
HEART DISEASE
   A.T. Ivashchenko, R.E. Niyazova, S.A. Atambayeva,
   A.Y. Pyrkova ............................................... 109
SEX CHROMOSOME EVOLUTION IN PAMPHAGIDAE GRASSHOPPERS
   I.E. Jetybayev, A.G. Bugrov, O.G. Buleu, A.G. Bogomolov,
   N.B. Rubtsov ............................................... 110
DNA REPAIR AND DEATH SIGNALING TARGETED BY ALKYLATING 
ANTICANCER DRUGS
   B. Kaina ................................................... 111
FUNCTIONAL ANALYSIS OF RNA-SEQ TRANSCRIPTOMES FROM 
OESOPHAGEAL CANCER SPECIMENS OF KAZAKHSTANI PATIENTS
   U. Kairov, A. Molkenov, S. Rakhimova, A. Abilmazhinova,
   M. Zhalbinova, D. Yerezhepov, A. Akhmetova, Y. Zhukov, 
   M. Omarov, M. Popova, A. Zinovyev, A. Akilzhanova,
   Zh. Zhumadilov ............................................. 112
DIVERGENCE OF PARALOGOUS GROWTH HORMONE GENES IN SALMONIDS
   D.N. Kamenskaya, M.V. Pankova, D.M. Atopkin, V.A. Brykov ... 113
DINAMIC METBOLIC REGULATION BY A CHROMOSOME SEGMENT FROM 
A WILD SPECIES DURING FRUIT DEVELOPMENT IN A TOMATO 
INTROGRESSION LINE
   Y. Kanayama ................................................ 114
BASED ON THE LOCAL SEQUENCE SIMILARITY METHOD FOR PREDICTION
OF AMINO ACID POSITIONS RELATED TO THE PROTEIN-LIGAND 
SPECIFICITY
   D.A. Karasev, A.V. Veselovsky, N.Yu. Oparina, A.V. Rudik, 
   D.A. Filimonov, B.N. Sobolev ............................... 115
SEQUENCING FROM ROCHE: WHAT THE FUTURE WILL BRING FOR YOU?
   I.Y. Karpova ............................................... 116
BIOMOLECULAR SYSTEMS MODELS SEMI-AUTOMATIC RECONSTRUCTION 
BASED ON STRUCTURAL AND QUANTITATIVE INFORMATION
   F.V. Kazantsev, I.R. Akberdin, S.A. Lashin, N. Ree, 
   V. Timonov, A.V. Ratushny, T.M. Khlebodarova, 
   V.A. Likhoshvai ............................................ 117
REGULATORY ROLE OF SINGLE CPG METHYLATION
   A. Khamis, A.V. Artemov, A.V. Lioznova, V.B. Bajic, 
   Y.A. Medvedeva ............................................. 118
GENETIC DIVERSITY IN NATIVE SIBERIAN POPULATIONS: 
CORRELATION WITH CLIMATIC AND GEOGRAPHICAL PARAMETERS
   V.N. Kharkov, A.V. Markov, I.Yu. Khitrinskaya, 
   V.A. Stepanov .............................................. 119
THE INFLUENCE OF RARE MUTATIONS IN THE APOB GENE TO THE
LEVEL OF OXIDIZED LDL
   E.Yu. Khlebus, N.V. Shcherbakova, I.S. Zhanin,
   A.A. Zharikova, A.I. Ershova, A.V. Kiseleva, 
   S.A. Boytsov, A.N. Meshkov ................................. 120
WHAT WE USUALLY STUDY WHEN WE THINK WE STUDY AGING
   A.N. Khokhlov .............................................. 121
THE FIRST EDITION OF MUTAGENESIS BY CRISPR/CAS IN THE 
EXTREME DESICCATION TOLERANT CULTURED CELL
   T. Kikawada, Y. Miyata, Y. Sogame, T. Furusawa, 
   S. Kikuta, R. Cornette, O. Gusev ........................... 122
ANHYDRO-PRESERVATION OF EXOGENOUSLY-EXPRESSED DESICCATION-
SENSITIVE ENZYME LUCIFERASE USING INSECT CELLS
   S. Kikuta, S. Watanabe, O. Gusev, Y. Sogame, R. Cornette, 
   T. Kikawada ................................................ 123
MOLECULAR DYNAMICS CHARACTERIZATION OF GLYCYRRHIZIN 
INTERACTION WITH LIPID MEMBRANES
   A.V. Kim, E.A. Shelepova, N.N. Medvedev .................... 124
GENOMEASIA 100K INITIATIVE ANNOUNCED TO SEQUENCE 100,000
GENOMES IN SOUTH, NORTH AND EAST ASIA
   H.L. Kim, E.S. Gusareva, S.C. Schuster ..................... 125
THE SIGNIFICANCE OF DISSOCIATIVE NUCLEOTIDE CHANGES 
ACCUMULATION RATE IN THE GENOTYPE VARIABILITY OF TICK-BORNE
ENCEPHALITIS VIRUS FOR GENE E
   D.O. Kiselev, S.Ju. Bukin, A.I. Paramonov, Ju.P. Dzhioev,
   V.I. Zlobin ................................................ 126
FUNCTIONAL AND STRUCTURAL CHARACTERISATION OF PPD-B1
PHOTOPERIOD INSENSITIVE ALLELE
   A.A.Kiseleva, E.A. Salina .................................. 127
PHAGE INFECTION SLOWS DOWN SPECIATION CAUSED BY GENE LOSS 
AND HORIZONTAL GENE TRANSFER OF METABOLIC GENES IN MODELS OF
SPATIALLY DISTRIBUTED BACTERIAL COMMUNITIES
   A.I. Klimenko, Yu.G. Matushkin, N.A. Kolchanov, 
   S.A. Lashin ................................................ 128
HAPLOID EVOLUTIONARY CONSTRUCTOR 3D: A FRAMEWORK FOR 
MULTILAYER MODELING OF SPATIALLY DISTRIBUTED MICROBIAL 
COMMUNITIES
   A.I. Klimenko, Yu.G. Matushkin, Z.S. Mustafin,
   A.D. Chekantsev, R.K. Zudin, S.A. Lashin ................... 129
MONOTROPA HYPOPITYS WHOLE GENOME AND TRANSCRIPTOME 
SEQUENCING DATA
   E.Z. Kochieva, E.V. Gruzdev, A.V. Beletsky, A.M. Mazur, 
   A.V. Shchennikova, O.V. Shulga, M.A. Filyushin, 
   V.V. Kadnikov, A.V. Mardanov, N.V. Ravin, K.G. Skryabin .... 130
THE INTERACTION BETWEEN ANAEROBIC RESPIRATORY COMPLEX II
AND THE FLAGELLAR MOTOR
   A. Koganitsky, T. Dadosh, V. Kiss, M. Eisenbach ............ 131
VIRTUAL BIOLOGY - THE FOUNDATION
   F.A. Kolpakov .............................................. 132
WheatDB2: PLANT TRAIT DATABASE AND INFORMATION SYSTEM BASED 
ON CROP ONTOLOGY TERMS
   E.G. Komyshev, M.A. Genaev, A.V. Akushkina, 
   D.A. Afonnikov ............................................. 133
ASSESSMENT OF TRANSLATIONAL IMPORTANCE OF MAMMALIAN MRNA
SEQUENCE FEATURES BASED ON RIBO- AND MRNA-SEQ DATA
   Yu.V. Kondrakhin, R.N. Sharipov, O.A. Volkova .............. 134
MACROEVOLUTIONARY AND EXPERIMENTAL ASSAYS OF FITNESS 
LANDSCAPES
   F. Kondrashov .............................................. 135
IT ANALYSIS OF CORNEA ENDOTHELIUM TRANSPORT ABILITY IN 
CORNEAL TRANSPLANTS AFTER HYPOTHERMIC CONSERVATION
   A.A. Konev, I.G. Palchikova, I.A. Iskakov, L.E. Katkova,
   G.S. Baturina, E.I. Solenov ................................ 136
INVASIVE ENTOMO-MYCOLOGICAL ASSOCIATION OF P. PROXIMYS AND 
ITS PHYTOPATOGENIC SYMBIONT IN SIBERIA AND EUROPEAN PART OF
RUSSIA
   A. Kononov, A. Blinov, N. Pashenova, N. Percova, 
   Y. Baranchikov ............................................. 137
GENETIC DIVERSITY AMONG EIGHT DENDROLIMUS SPECIES IN 
EURASIA (LEPIDOPTERA: LASIOCAMPIDAE) INFERRED FROM 
MITOCHONDRIAL COI AND COII, AND NUCLEAR ITS2 MARKERS
   A. Kononov, K. Ustyantsev,B. Wang, V. Mastro, V. Fet,
   A. Blinov, Y. Baranchikov .................................. 138
VRNI GENES VARIABILITY IN TETRAPLOID WHEAT SPECIES WITH 
A SPRING GROWTH HABIT
   I. Konopatskaia, V. Vavilova, E.Ya. Kondratenko, 
   A. Blinov, N.P. Goncharov .................................. 139
GENOME OF BLACK GARDEN ANT: DEFENSE AGAINST VIRUS INVASION?
   E.A. Konorov, V.A. Scobeyeva, M.A. Nikitin, 
   S.N. Lysenkov, S. Nuzhdin .................................. 140
MOLECULAR EVOLUTION ANALYSIS OF GENES RELATED TO PLANT ROOT
HAIR AND TRICHOME DEVELOPMENT
   D.Yu. Konstantinov, A.V. Doroshkov ......................... 141
TWO CONGENIC STRAINS PROVE EFFECTS ON CATARACT AND 
RETINOPATHY BUT NOT ON BRAIN NEURODEGENERATION IN 
SENESCENCE-ACCELERATED OXYS RATS
   E.E. Korbolina, A.O. Vitovtov, N.G. Kolosova ............... 142
ASSOCIATION OF MATRIX METALLOPROTEINASES GENE POLYMORPHISM
WITH THE RISK OF DEVELOPING EXTRA-ARTICULAR SYMPTOMS OF 
RHEUMATOID ARTHRITIS
   M.A. Korolev, Y.B. Ubshaeva, E.A. Letyagina, 
   A.V. Shevchenko, V.F. Prokof'yev, V.I. Konenkov ............ 143
GENERALISING BETTER: APPLYING DEEP-LEARNING TO INTEGRATE 
DELETERIOUSNESS PREDICTION SCORES FOR WHOLE-EXOME SNV 
STUDIES 
   I.O. Korvigo, A.A. Afanasyev ............................... 144
KU ANTIGEN DISPLAYS THE AP LYASE ACTIVITY ON A CERTAIN
TYPE OF DUPLEX DNA
   A.A. Kosova, S.N. Khodyreva, O.I. Lavrik ................... 145
INVOLVEMENT OF VARIOUS CELL DEATH MODALITIES IN CYTOTOXIC
ACTIVITY OF LACTAPTIN ANALOG
   O.A. Koval, G.V. Kochneva, A.V. Tkachenko,
   O.S. Troitskaya, G.F. Sivolobova, E.V. Kuligina,
   A.Y. Yunusova, V.A. Richter ................................ 146
INCONGRUENT NUCLEAR AND MITOCHONDRIAL GENETIC STRUCTURE IN
BAIKALIAN AMPHIPODS GMELINOIDES FASCIATUS
   M.V. Kovalenkova, Zh.V. Petunina, D.Yu. Sherbakov .......... 147
MATHEMATICAL MODELING A RECIPROCAL INTERACTIONS BETWEEN 
AUXIN AND ITS PIN TRANSPORTERS IN THE ROOT TIP OF A. 
THALINA L
   V.V. Kovriznykh, F.V. Kazantsev, N.A. Omelyanchuk, 
   V.V. Mironova .............................................. 148
TWO MODELS OF THE DROSOPHILA GAP GENE NETWORK WITH VARIATION
OF MATHERNAL INPUT
   K.N. Kozlov, A.V. Svichkarev, V.V. Gursky, 
   I.V. Kulakovskiy, S.Y. Surkova, M.G. Samsonova ............. 149
COMPARATIVE GENOMICS AND TRANSCRIPTOMICS OF CHIRONOMIDAE 
MIDGES UNDER EXTREME CONDITIONS
   O.S. Kozlova, A.V. Cherkasov, R.M. Devyatiarov, 
   M.D. Logacheva, R. Cornette, T. Kikawada, A.A. Przhiboro,
   O.A. Gusev ................................................. 150
COMPARATIVE TRANSCRIPTOMICS PROVIDES NEW INSIGHTS INTO 
ORIGIN OF EXTRAORDINARY RESISTANCE TO DESICCATION IN
AUSTRALIAN MIDGE PARABORNIELLA TONNOIRI (CHIRONOMIDAE)
   O.S. Kozlova, E.I. Shagimardanova, L.Kh. Shigapova, 
   R.M. Devyatiarov, M.D. Logacheva, R. Cornette, 
   T. Kikawada, O.A. Gusev .................................... 151
TRAJECTORIES OF THE DNA KINKS IN THE SEQUENCES CONTAINING
CDS regions
   L.A. Krasnobaeva, L.V. Yakushevich ......................... 152
INMETHYL: A TOOL FOR DESIGN OF SPECIFIC PRIMERS FOR 
METHYLATION PROFILING OF COMPLETE CPG ISLANDS
   G.S. Krasnov, A.V. Kudryavtseva, N.V. Melnikova, 
   A.A. Dmitriev .............................................. 153
RTRANS: ANALYSIS OF RNA-SEQ DIFFERENTIAL EXPRESSION USING 
GLM APPROACH AND UNCOVERING ITS BIOLOGICAL BACKGROUND
   G.S. Krasnov, A.V. Snezhkina, N.V. Melnikova, 
   A.A. Dmitriev, A.V. Kudryavtseva ........................... 154
DIFFERENTIAL EXPRESSION OF ALTERNATIVELY SPLICED 
TRANSCRIPTS RELATED TO ENERGY METABOLISM IN COLORECTAL
CANCER
   G.S. Krasnov, A.V. Snezhkina, I.Y. Karpova, 
   O.L. Kardymon, M.S. Fedorova, A.A. Moskalev,
   A.F. Sadritdinova, K.M. Nyushko, N.V. Melnikova,
   D.V. Kalinin, A.A. Belova, M.A. Chernichenko,
   K.M. Klimina, D.V. Sidorov, A.Y. Popov, A.A. Dmitriev, 
   A.V. Kudryavtseva .......................................... 155
FAIRDOM: DATA AND MODEL MANAGEMENT FOR SYSTEMS BIOLOGY 
PROJECTS
   O. Krebs, R. Kuzyakiv, M. Golebiewski, S. Owen, 
   Q. Nguyen, N. Stanford, K. Wolstencroft, J.L. Snoep, 
   B. Rinn, W. Mueller, C. Goble .............................. 156
THE MITOCHONDRIA-TARGETED PLASTOQUINONE SKQ1 AFFECTS 
DROSOPHILA MELANOGASTER LIFESPAN IN VARIOUS ENVIRONMENTS
   A.V. Krementsova, N.V. Roshina, E.A. Tsybul'ko, 
   O.Y. Rybina, A.V. Symonenko, E.G. Pasyukova ................ 157
REGULATION OF BASE EXCISION REPAIR – CANONICAL AND 
NON-CANONICAL PROCESSING OF GENOMIC URACIL
   H.E. Krokan, H.S. Pettersen, R. Mjelle, S.A. Hegre, 
   P. Sжtrom, F. Drablшs, A. Sarno, A. Galashevskaya, 
   P.A. Aas, N.B. Liabakk, B. Doseth, G. Slupphaug,
   B. Kavli ................................................... 158
EFFECT OF LENTIVIRUS-MEDIATED shRNA INACTIVATION OF HK1,
HK2, AND HK3 GENES N COLORECTAL CANCER AND MELANOMA CELLS
   A.V. Kudryavtseva, M.S. Fedorova, O.L. Kardymon, 
   A.A. Dmitriev, A.I. Afremova, D.V. Kochetkov, 
   A.V. Lipatova, A.F. Sadritdinova, I.Y. Karpova, 
   K.M. Nyushko, D.V. Kalinin, N.N. Volchenko,
   N.V. Melnikova, A.A. Belova, M.A. Chernichenko, 
   K.M. Klimina, N.V. Nasedkina, A.S. Zasedatelev, 
   D.V. Sidorov, A.Y. Popov, G.S. Krasnov, A.V. Snezhkina ..... 159
COMPUTER SOFTWARE FOR STATISTICAL ANALYSIS OF GENES 
LOCATION RELATIVE TO CHROMOSOME CONTACTS REVEALED BY ChIA-PET
   E.V. Kulakova, A.M. Spitsina ............................... 160
SYSTEMIC ROLE OF ALLELIC VARIANTS IN A 2Q22 REGION IN 
MAJOR AGE-RELATED DISEASES AND LIFESPAN
   A.M. Kulminski, L. He, I. Culminskaya, Y. Loika, 
   Y. Kernogitski, K.G. Arbeev, E. Loiko, L. Arbeeva, 
   O. Bagley, M. Duan, A. Yashkin, F. Fang, M. Kovtun, 
   S.V. Ukraintseva, D. Wu, A.I. Yashin ....................... 161
COMPARATIVE EXPRESSION LANDSCAPES IN REPLICATIVE AND STRESS 
INDUCED PREMATURE SENESCENCE
   K.C. Kural, N. Tandon, O.V. Kel-Margoulis, A. Baranova ..... 162
TRANSCRIPTOMICS OF THE CRYOBIOTIC LEECH OZOBRANCHUS 
JANTSEANUS
   S.V. Kuznecova, D. Suzuki, M.D. Logacheva, O.S. Kozlova, 
   T. Kikawada, R.M. Sabirov, O.A. Gusev ...................... 163
A MATHEMATICAL MODEL FOR PREDICTING OF IgD–CD27+B 
LYMPHOCYTES LEVELS IN DONORS' BLOOD
   S.R. Kuznetsov, I.V. Kudryavtsev, A.V. Orekhov, 
   A.V. Polevshchikov, M.K. Serebriakova, V.I. Shishkin ....... 164
TARGET ENRICHMENT TECHNOLOGIES FOR APPLIED RESEARCH
   D.A. Kwon .................................................. 165
CHARACTERIZATION OF NOVEL ALKANE-DEGRADING AND 
BIOSURFACTANT-PRODUCING STRAIN TSUKAMURELLA TYROSINOSOLVENS
PS2
   A.V. Laikov, E.A. Boulygina, V.A. Romanova, 
   T.V. Grigorieva ............................................ 166
3D MAP OF PROLIFERATION ACTIVITY IN ARABIDOPSIS THALIANA
ROOT TIPS: TRANSITION DOMAIN BOUNDARIES AND ITS BILATERAL
SYMMETRY
   V.V. Lavrekha, T. Pasternak, N.A. Omelyanchuk,
   V.B. Ivanov, V.V. Mironova ................................. 167
POLY(ADP-RIBOSE) POLYMERASE 1 AND REGULATION OF DNA REPAIR
   O.I. Lavrik ................................................ 168
TOWARDS UNDERSTANDING THE DYNAMICS OF DEATH RECEPTOR NETWORKS
   O.I. Lavrik ................................................ 169
DOES THYROID DIVERGENCE SERVE AS A DRIVER OF SPECIATION IN 
CYPRINID FISHES OF THE GENUS BALLERUS (TELEOSTEI)?
   B.A. Levin, A.A. Bolotovskiy, M.A. Levina, 
   A.V. Nedoluzhko, K.G. Skryabin, S.M. Rastorguev,
   E.B. Prokhortchouk ......................................... 170
DIFFERENTIAL ANALYSIS OF THREE-DIMENSIONAL (3D) GENOMICS
DATA
   G. Li ...................................................... 171
GENOTYPE DISTRIBUTION IN PATIENTS WITH CHRONIC HEPATITIS C 
ANALYSIS USING MULTIFACTOR DIMENSIONALITY REDUCTION METHOD
   A.D. Liaudanski, M.S. Rodzkin, V.S. Pankratov, 
   D.E. Danilau, I.A. Karpov, O.G. Davydenko .................. 172
POSTGENOME MEDICINE AS N-OF-ONE SCIENCE
   A.V. Lisitsa, E.V. Kolker, H. Chen, V.E. Frankevich ........ 173
DNA DUPLEX STRUCTURE AND THERMODYNAMICS BY MOLECULAR 
DYNAMICS SIMULATION
   A.A. Lomzov, D.V. Pyshnyi .................................. 174
EVOLUTION OF PHENOTYPIC CONTROL BY NEW GENES THROUGH 
INTEGRATING AND REWIRING OF ANCESTRAL EXPRESSION NETWORKS
   M. Long .................................................... 175
TARGETED SPATIAL GENOME MODIFICATION IN TOPOLO-GICALLY 
ASSOCIATING DOMAINS STRUCTURE IN MOUSE EMBRYONIC STEM CELLS
   V.A. Lukyanchikova, N.R. Battulin, O.L. Serov .............. 176
THE DENSITY OF WOLBACHIA STRAIN WMELPOP IN DROSOPHILA 
MELANOGASTER BRAIN IS INVERSELY RELATED TO THE LEVEL OF 
HSP67Bc GENE EXPRESSION
   D.A. Malkeyeva, E.V. Kiseleva .............................. 177
PREDICTION OF FUNCTIONAL EFFECTS OF REGULATORY SEQUENCE 
VARIATIONS
   M. Malkowska, J. Zubek, D. Plewczynski, L.S. Wyrwicz ....... 178
MOLECULAR EVOLUTION AND SYSTEMATICS OF FLAT LEECHES 
(HIRUDINEA: GLOSSIPHONIIDAE)
   N.B. Mandzyak, I.A. Kaygorodova ............................ 179
PREDICTION OF STRUCTURAL PROPERTIES OF UNCHARACTERIZED 
PROTEINS FROM THEIR POST-CLEAVAGE MASS SPECTRA BY 
A MULTIVARIATE STATISTICAL MODEL
   O.A. Markelov, A.R. Kayumov, M.I. Bogachev ................. 180
ON THE POSSIBLE IMPACT OF EXOGENOUS 8-OXO-2'-DEOXYGUANOSINE 
ON DNA SYNTHESIS, DAMAGE AND REPAIR IN AGING CELL CULTURES
AND ORGANISM
   N.V. Marmiy, G.V. Morgunova, D.S. Esipov, A.N. Khokhlov .... 181
MOLECULAR EVOLUTION ANALYSIS OF RNA-BINDING NIP7 PROTEIN 
FROM DEEPAND SHALLOW-WATER ARCHAEA
   K.E. Medvedev, D.A. Afonnikov .............................. 182
HIGH TEMPERATURE AND PRESSURE INFLUENCE ON INTERDOMAIN 
INTERFACE OF THE NIP7 PROTEINS FROM P. ABYSSI AND 
P. FURIOSUS: MD SIMULATION RESEARCH
   K.E. Medvedev, D.A. Afonnikov .............................. 183
SITEX 2.0: FUNCTIONAL SITES PROJECTION ON ALTERNATIVE 
SPLICED ISOFORMS AND HOMOLOGOUS GENES
   I.V. Medvedeva, P.S. Demenkov, V.A. Ivanisenko ............. 184
PROGRAM COMPLEX ICGenomics FOR ANALYSIS OF HIGH-THROUGHPUT 
SEQUENCING EXPERIMENTS
   I.V. Medvedeva, A.O. Bragin, K.V. Gunbin, P.S. Demenkov, 
   O.V. Vishnevsky, A.M. Spitsina, F.M. Naumenko, 
   V.N. Babenko, N.L. Podkolodnyy, Y.L. Orlov ................. 185
NONTHERMAL IMPACT TERAHERTZ RADIATION ON THE LIVING SYSTEMS
   I.A. Mescheryakova, E.V. Demidova, T.N. Goryachkovskaya, 
   E.A. Demidov, A.V. Bryanskaya, S.V. Sergeeva, 
   S.L. Kiselev, M.A. Lagarkova, G.N. Kulipanov, 
   A.I. Semenov, N.A. Vinokurov, N.A. Kolchanov, V.M. Popik, 
   S.E. Peltek ................................................ 186
BIOMARKERS OF AGE IN THE "STATIONARY PHASE AGING" MODEL
   G.V. Morgunova, D.S. Esipov, M.V. Marmiy, A.N. Khokhlov .... 187
k-MER FREQUENCY DISTRIBUTION OF EUKARYOTIC PROTEOMES
   A.A. Morozov ............................................... 188
CAN LONG ANTIPARALLEL OPEN READING FRAMES BE ENCODING 
ESSENTIAL GENES IN PROKARYOTIC GENOMES?
   D.M. Moshensky, A.V. Alexeevski ............................ 189
GEROPROTECTOR AND CRITERIA FOR ITS EVALUATION
   A. Moskalev, M. Shaposhnikov, E. Proshkina, V. Tsvetkov, 
   A. Fedintsev, E. Chernyagina, A. Zhavironkov ............... 190
PHOSPHORYLATION OF ?B-CRYSTALLIN: EFFECTS OF AGING AND 
CARDIOMYOPATHY
   N.A. Muraleva, V.A. Devyatkin, N.A. Kolosova ............... 191
ADVANCED CAPABILITIES OF VISUALIZATION AND ANALYSIS OF 
CULTURAL MODELS
   E.R. Muslikhov, L.A. Strukova .............................. 192
ORTHOSCAPE: A CYTOSCAPE PLUGIN FOR EVOLUTIONARY ANALYSIS OF 
GENE NETWORKS
   Z.S. Mustafin, D.A. Afonnikov, K.V. Gunbin,
   Yu.G. Matushkin, S.A. Lashin ............................... 193
CROSSING VALLEYS AND REACHING PEAK ON THE FITNESS LANDSCAPES 
IN MICROBIAL COMMUNITIES UNDER VARIOUS ECOLOGICAL 
CONDITIONS: A SIMULATION STUDY
   Z.S. Mustafin, D.A. Afonnikov, Yu.G. Matushkin,
   S.A. Lashin ................................................ 194
POLYMORPHISM OF THE VRN-A1 EXON-4 AND EXON-7 IN POLYPLOID 
WHEAT
   A.F. Muterko, E.A. Salina .................................. 195
PROTEOMIC OF TCA - EXTRACTED COMPOUNDS, ISOLAT?D FROM HUMAN 
BLOOD SERUM REVEALED NEW POTENTIAL BIOMARKERS, ASSOSIATED 
WITH AUTOIMMUNE AND HEMATOONCOLOGICAL DISEASES
   S. Myronovkij, M. Starykovych, Y. Bobak, N. Negrych, 
   T. Nehrych, M. Shorobura, O. Shalay, S. Souchelnytskyi, 
   R. Stoika, Y. Kit .......................................... 196
COMPUTER AIDED DRUG DESIGN: DEVELOPMENT MODELS FOR 
SPECIFICITY, POLYPHARMOCOLOGY AND MEMBRANE PERMEABILITY
   G.N. Sastry, S. Janardhan, A.S. Gaur, V. Poroikov .......... 197
STUDY ON THE REGULATION OF CELL DIVISION DURING EARLY FRUIT
DEVELOPMENT IN TOMATO
   H. Nariyama, T. Shibuya, Y. Kanayama ....................... 198
WHOLE GENOME OF THE WOOLY MAMMOTH: EVOLUTION THROUGH MILLENIA
   A.V. Nedoluzhko, A.S. Sokolov, F.S. Sharko, 
   E.S. Boulygina, S.V. Tsygankova, A.N. Tikhonov,
   K.G. Skryabin, E.B. Prokhortchouk .......................... 199
REGULATION OF THIOREDOXIN GENES EXPRESSION IN 
DESICCATION-TOLERANT INSECT POLYPEDILUM VANDERPLANKI
   A.A. Nesmelov, E.I. Shagimardanova, M.D. Logacheva, 
   R. Cornette, T. Kikawada, O.A. Gusev ....................... 200
DEVELOPMENT OF MICROSATELLITE MARKERS ACCORDING TO BAC
SEQUENCING DATA AND THEIR PHYSICAL MAPPING TO THE BREAD
WHEAT 5B CHROMOSOME
   M.A. Nesterov, D.A. Afonnikov, E.M. Sergeeva, 
   L.A. Miroshnichenko, M.K. Bragina, A.O. Bragin,
   G.V. Vasiliev, E.A. Salina ................................. 201
CMSEARCH: TOOL FOR SEARCHING TFBS COMPOSITE MODULES IN DNA
SEQUENCES
   S.I. Nikitin, E.S. Cheryomushkin ........................... 202
A CONGESTION GAME MODEL FOR VIRTUAL DRUG SCREENING IN 
A DESKTOP GRID
   N.N. Nikitina, E.E. Ivashko ................................ 203
MECHANICS OF PLANT CELL UNIDIRECTIONAL GROWTH
   S.V. Nikolaev, S.K. Golushko, U.S. Zubairova, 
   D.A. Afonnikov ............................................. 204
IN SILICO SCREENING FOR SULFONATE-BASED INHIBITORS AGAINST
PROMISING ANTICANCER TARGETS
   D.K. Nilov, I.V. Gushchina, V.K. Љvedas .................... 205
PROTEOMIC SCREENING FOR AMYLOID-FORMING PROTEINS IN BACTERIA
ESCHERICHIA COLI
   A.A. Nizhnikov, K.S. Antonets, K.V. Volkov, 
   A.L. Maltseva, A.P. Galkin ................................. 206
IDENTIFICATION OF STURGEON SPECIES WITH MTDNA AND 
MICROSATELLITE MARKERS IN BELARUS
   A.Yu. Nosova ............................................... 207
MEMBRANE-ASSOCIATED KINASE REGULATORS OF MAKR FAMILY GENES 
IN ARABIDOPSIS THALIANA L.
   D.D. Novikova, N.A. Omelyanchuk, V.V. Mironova ............. 208
MAPPING THE INTERACTION SITE FOR THE MESOBUTHUS SCORPION
TOXINS IN THE VOLTAGEGATED POTASSIUM CHANNEL KV1.2
   V.N. Novoseletsky, A.D. Volyntceva, K.V. Shaitan ........... 209
DISTRIBUTION OF 2541-2542DELCA KDPD FRAMESHIFT MUTATION IN 
GENOMES OF MYCOBACTERIUM TUBERCULOSIS FROM IRKUTSK OBLAST 
AND YAKUTIA
   O. Ogarkov, V. Sinkov, I. Mokrousov, S. Zhdanova,
   P. Khromova, E. Orlova ..................................... 210
VASCULAR ENDOTHELIAL GROWTH FACTOR POLYMORPHISMS ARE
ASSOCIATED WITH THE EARLIER ONSET OF RHEUMATOID ARTHRITIS
   V.O. Omelchenko, M.A. Korolev, E.A. Letyagina, 
   A.V. Shevchenko, V.F. Prokof'yev, T.I. Pospelova, 
   V.I. Konenkov .............................................. 211
THEORETICAL MODEL OF MITOTIC SPINDLE MICROTUBULE GROWTH FOR
FRAP CURVE INTERPRETATION
   L.V. Omelyanchuk, A.F. Munzarova, T.Y. Mikhailova .......... 212
SEQUENCING OF CONIFER GENOMES USING NGS
   N.V. Oreshkova, Yu.A. Putintseva, D.A. Kuzmin, 
   V.V. Sharov, V.V. Biryukov, S.V. Makolov, K.V. Krutovsky ... 213
CLUSTER ANALYSIS OF STRESS-INDUCED DUPLEX DESTABILIZATION 
(SIDD) PROFILES FOR E. COLI PROMOTERS
   M.A. Orlov, A.A. Ryasik, E.A. Temlyakova, A.A. Sorokin ..... 214
COMPUTER ANALYIS OF DISTAL GENE REGULATION USING CHROMOSOME 
CONTACTS DATA
   Y.L. Orlov, E.V. Kulakova, A.G. Bogomolov, V.N. Babenko, 
   G. Li ...................................................... 215
DIOXIN-MEDIATED UPREGULATION OF ONCOSTATIN M IN U937 
MACROPHAGES
   D.Y. Oshchepkov, E.V. Kashina, V.A. Mordvinov, 
   D.P. Furman ................................................ 216
IN SILICO MOUSE CHROMOCENTERS CONTENT
   D.I. Ostromyshenskii, A.S. Komissarov, I.S. Kuznetsova, 
   O.I. Podgornaya ............................................ 217
THE GENOME WIDE ANALYSIS OF THE LARGE TANDEM REPEATS IN THE
CLOSELY RELATED GENOMES
   D.I. Ostromyshenskii, O.I. Podgornaya ...................... 218
   ELECTROSTATICS: A NEW OLD GENOME SELECTION FACTOR
   A.A. Osypov ................................................ 219
DIFFERENTIAL EXPRESSION IN HELIX LUCORUM STATOCYSTS UNDER
MICROGRAVITY CONDITIONS
   A.A. Osypov, P. Kolosov, N. Aceyev, E. Chesnokova, 
   M. Roshchin, N. Bal, P. Balaban ............................ 220
SYSTEM SIMULATION: NEURON, MUSCLE AND SIGNAL PROPAGATION
MODELLING
   A.Yu. Palyanov, Kh.V. Samoilova ............................ 221
SEARCH FOR FUNCTIONAL NF-KB BINDING SITES VIA META-ANALYSIS 
OF NGS EXPERIMENTS IN HUMAN CELL LINES
   N. Panyushev, E. Lomert, D. Tentler, A. Predeus ............ 222
NEW INSIGHTS INTO THE REGULATION OF REACTIVE OXYGEN SPECIES 
BY AUXIN THROUGH GENE EXPRESSION ANALYSIS
   I.A. Paponov, V. Budnyk, T. Khodus, M. Paponov, K. Palme ... 223
IDENTIFICATION OF RECOMBINATION SITES IN THE GENOMES OF THE
EUROPEAN SUBTYPE OF TICK BORNE ENCEPHALITIS VIRUS
   A.I. Paramonov, Yu.P. Dzhioev, I.V. Kozlova ................ 224
DARWINIAN GENETIC DRIFT
   D.V. Parkhomchuk, A.C. McHardy ............................. 225
IMPACT OF 105-DAY ISOLATION CONDITIONS ON PROTEINS EXPRESSED 
IN ENDOTHELIAL CELLS, IN THE FRAMEWORK OF THE "MARS-500"
PROJECT
   L.Kh. Pastushkova, D.N. Kashirina, A.S. Kononikhin, 
   A.G. Brzhozovsky, I.V. Dobrokhotov, E.S. Tiys, 
   V.A. Ivanisenko, E.N. Nikolaev, I.M. Larina ................ 226
THE ROLE OF KINETOCHORE-DRIVEN MICROTUBULE FORMATION IN 
DROSOPHILA SPINDLE ASSEMBLY
   G. Pavlova, J. Popova, A. Munzarova, J. Galimova, 
   A. Razuvaeva, F. Renda, P. Somma, A. Pindyurin, M. Gatti ... 227
MICROBIAL COMMUNITY OF THE OIL SITE OF THE UZON CALDERA
(KAMCHATKA)
   S.E. Peltek, A.V. Bryanskaya, Y.E. Uvarova, A.S. Rozanov,
   T.V. Ivanisenko, T.K. Malup, V.A. Ivanisenko, 
   E.V. Lazareva, O.V. Saik, S.M. Zhmodik, O.P. Taran, 
   N.M. Slynko, S.V. Shekhovtsov, V.N. Parmon, 
   N.L. Dobretsov, N.A. Kolchanov ............................. 228
PQ: A NEW PROGRAM FOR PHYLOGENETIC RECONSTRUCTION
   D. Penzar, M.S. Krivozubov, S.A. Spirin .................... 229
THE BIOINFORNATIONAL COMPARISON OF CRISPR/CAS SYSTEM 
STRUCTURE OF YERSINIA PSEUDOTUBERCULOSIS STRAINS ISOLATED 
FROM DIFFERENT REGIONS
   N.P. Peretolchina, Y.P. Dzhioev , A.Y. Borisenko, 
   E.A. Voskresenskaya, A.I. Paramonov, L.A. Stepanenko,
   V.I. Zlobin ................................................ 230
SEARCH OF GENETIC SEQUENCES OF POTATOES IN DATABASES
   A.I. Perfileva ............................................. 231
HEAT SHOCK PROTEINS OF POTATO IN VITRO UNDER HEAT AND BIOTIC
STRESS
   A.I. Perfileva, E.G. Rikhvanov ............................. 232
MOSAIC GENE NETWORK MODELLING IDENTIFIED NEW REGULATORY 
MECHANISMS IN HCV INFECTION
   O.V. Petroskaya, E.D. Petrovskiy, E.L. Mishchenko,
   I.N. Lavrik, V.A. Ivanisenko ............................... 233
GUT MICROBIOTA IN CASE OF PARKINSON'S DISEASE AND OTHER 
NEUROLOGICAL PATHOLOGIES: COMPARATIVE STUDY
   V.A. Petrov, V.M. Alifirova, I.V. Saltykova, 
   Y.B. Dorofeyeva, A.V. Tyakht, E.S. Kostryukova,
   A.E. Sazonov ............................................... 234
WORKFLOW FOR EXOME SEQUENCING IN IDENTIFICATION OF DE NOVO
MUTATION IN THE NCL6 GENE
   D.A. Petukhova, N.R. Maksimova, P.I. Guryeva, 
   V.S. Kaymonov, M.T. Savvina ................................ 235
miRNA BINDING SITES in the mRNA OF HUMAN TITIN GENE
   I.V. Pinsky, A.T. Ivashchenko, S.B. Labeit ................. 236
BIOSTORE: A CLOUD-COMPATIBLE HUB FOR BIOINFORMATICS RELATED
TOOLS AND PLATFORMS
   S. Pintus, T. Valeev, I. Yevshin, F. Kolpakov .............. 237
COMPUTATIONAL MODEL FOR MAMMALIAN CIRCADIAN OSCILLATOR 
INTERACTING WITH NAD+ / SIRT1 PATHWAY
   O.A. Podkolodnaya, N.N. Tverdokhleb, N.L. Podkolodnyy ...... 238
COMPUTER ANALYSIS OF BIOLOGICAL NETWORKS OF MAMMALIAN 
CIRCADIAN OSCILLATOR
   N.L. Podkolodnyy, N.N. Tverdokhleb, E.O. Sambilova,
   S.A. Lobynya, Z.D. Yakubova, O.A. Podkolodnaya ............. 239
QUANTITATIVE CONTRIBUTION OF IL2RG TO THE DYNAMIC 
FORMATION OF IL2-IL2R COMPLEXES
   L.F. Ponce, K.Garcнa-Martнnez, K. Leуn ..................... 240
EPIGENOMIC CHANGES IN POSTMORTEM BRAINS OF HUMAN ALCOHOLICS
   I. Ponomarev ............................................... 241
PUNCTUATED EVOLUTION: THE RELATIONSHIP BETWEEN RARE MUTATIONS
AND CLADOGENESIS OF VERTEBRATES
   K. Popadin, K. Gunbin ...................................... 242
TASSE: A NEW APPROACH TO SOLVENT TREATMENT IN MOLECULAR 
DYNAMICS
   A.V. Popov, Yu.N. Vorobjev, D.O. Zharkov ................... 243
COMPUTER-AIDED DRUG REPURPOSING: NEW USES FOR OLD DRUGS OR 
FILLING GAPS IN BIOMEDICAL KNOWLEDGE?
   V.V. Poroikov, D.A. Filimonov, A.A. Lagunin, 
   T.A. Gloriozova ............................................ 244
INTRON EVOLUTION: SLIDING AND VARIABILITY OF LENGTH
   I.V. Poverennaya, D.D. Gorev, T.V. Astakhova, 
   M.A. Roytberg .............................................. 245
DNA DAMAGE AND GENERATION OF REACTIVE OXYGEN SPECIES BY 
PLATINUM DRUGS: EXPERIMENTS ON BACTERIA
   E.V. Prazdnova, V.A. Chistyakov, M.S. Mazanko, 
   M.N. Churilov, V.K. Chmyhalo ............................... 246
GENEQUERY: GLOBALLY CONNECTED NETWORKS OF GEO TRANSCRIPTIONAL
PROFILES SHOW HYPOTHESIS GENERATION POTENTIAL AND REVEAL THAT
TOCOPHEROLS RESCUE TREM2-ASSOCIATED MICROGLIAL DYSFUNCTION
   A.V. Predeus, T. Ulland, Y. Wang, V. Lampropoulou,
   W. Song, I. Arbuzov, F. Towfic, S. Gilfilan,
   E. Loginicheva, B.T. Edelson, B. Zeskind, M. Colonna,
   M.N. Artyomov .............................................. 247
THE ROLE OF HUNTINGTIN PROTEIN-PROTEIN INTERACTIONS IN THE 
PROCESSES OF CHANGING AND MAINTENANCE OF NEUROTRANSMISSION 
IN HIPPOCAMPUS
   A.L. Proskura, S.O. Vechkapova, T.A. Zapara, 
   A.S. Ratushniak ............................................ 248
STUDY OF ARMILLARIA BOREALIS PATHOGENICITY BY THE 
COMPARATIVE WHOLE GENOME SEQUENCING
   Yu.A. Putintseva, I.N. Pavlov, N.V. Oreshkova, 
   V.V. Sharov, D.A. Kuzmin, S.V. Makolov, K.V. Krutovsky ..... 249
RNA SEQ ANALYSIS OF MARINE AND FRESHWATER FORMS OF THREE-
SPINED STICKLEBACK (GASTEROSTEUS ACULEATUS). EVOLUTIONARY 
AND PHYSIOLOGICAL MECHANISMS OF ADAPTATION
   S.M. Rastorguev, A.V. Nedoluzhko, A.M. Mazur, 
   E.B. Prockhorchouk ......................................... 250
GENETIC AND MOLECULAR MECHANISMS CRUCIAL FOR HYPERTENSION 
DEVELOPMENT IN THE ISIAH RATS
   O.E.Redina, L.O.Klimov, M.A. Ryazanova, L.A. Fedoseeva,
   T.O. Abramova, Yu.V. Alexandrovich, S.E. Smolenskaya,
   Ye.V. Antonov, N.I. Ershov, V.M. Efimov, A.L. Markel ....... 251
ROLE OF MEMBRANE POTENTIAL IN NITRITE UTILIZATION BY
ESCHERICHIA COLI CELLS UNDER LOW SUBSTRATE CONCENTRATIONS:
THE MATHEMATICAL MODEL
   N.A. Ree, V.A. Likhoshvai, T.M. Khlebodarova ............... 252
MODELING RESTRICTION-MODIFICATION SYSTEMS: EXPRESSING TOXIC 
MOLECULES WITHIN A CELL
   A. Rodic, M. Djordjevic .................................... 253
GENETIC FITNESS OF DEAF PEOPLE IN THE SAKHA REPUBLIC
   G.P. Romanov , N.A. Barashkov , F.M. Teryutin, 
   L.A. Klarov, A.V. Solovyev, N.N. Gotovtsev, 
   V.G. Pshennikova, N.N. Sazonov, I.V. Morozov, 
   A.A. Bondar, L.U. Dzhemileva, E.K. Khusnutdinova, 
   O.L. Posukh, S.A. Fedorova ................................. 254
EVOLUTION OF MITOCHONDRIAL GENOMES IN BAIKALIAN AMPHIPODS
   E.V. Romanova, V.V. Aleoshin, K.V. Mikhailov, 
   R.M. Kamaltynov, M.D. Logacheva, E.A. Sirotinina,
   D.Yu. Sherbakov ............................................ 255
GENETIC DIVERSITY AND METABOLISM OF THE GARGA HOT SPRING 
MICROBIAL MAT
   A.S. Rozanov, A.V. Bryanskaya, T.K. Malup, 
   T.V. Ivanisenko, Yu.E. Uvarova, S.E. Peltek ................ 256
NEUROTHROPHIN SIGNALING PATHWAY IN DEVELOPMENT OF 
ALZHEIMER'S DISEASE-LIKE PATHOLOGY
   E.A. Rudnitskaya, N.A. Muraleva, N.A. Stefanova, 
   N.G. Kolosova .............................................. 257
DEVELOPMENT OF CATARACT AS THE BASIC SELECTION TRAIT IN THE
ONTOGENY OF SENESCENCE-ACCELERATED OXYS RATS
   Yu.V. Rumyantseva, A.Z. Fursova, E.E. Korbolina,
   N.G. Kolosova .............................................. 258
COMPARATIVE ANALYSIS OF EXPRESSION OF ANHYDROBIOSIS-RELATED
GENES IN RESPONSE TO DIFFERENT TYPES OF IONIZING RADIATION
IN THE SLEEPING CHIRONOMID (POLYPEDILUM VANDERPLANKI)
   A.V. Ryabova, A.V. Cherkasov, K. Mukae, T. Kikawada,
   T. Okuda, T. Sakashita, O. Gusev ........................... 259
GRAPH DATABASE FOR HUMAN MICROBIOME
   A.A. Ryasik, E.A. Temlyakova, M.A. Orlov, A.A. Sorokin ..... 260
NEURONAL TRANSCRIPTIONAL REGULATION OF DROSOPHILA LIFE SPAN
   O.Y. Rybina, A.V. Symonenko, N.V. Roshina, 
   A.V. Krementsova, E.R. Veselkina, M.I. Schelkunov, 
   S.V. Sarantseva, E.G. Pasyukova ............................ 261
SEARCH FOR GENE MUTATIONS THAT CAN POTENTIALLY AFFECT THE
SUSCEPTIBILITY TO TUBERCULOSIS
   O.V. Saik, P.S. Demenkov, E.U. Bragina, M. Freidin,
   A. El-Seedy, R. Hofestaedt, V.A. Ivanisenko ................ 262
ASSOCIATIVE NETWORKS OF GLAUCOMA AND APOPTOSIS
   O.V. Saik, P.S. Demenkov, O.S. Konovalova, 
   M.N. Ponomareva, N.A. Konovalova, N.A. Kolchanov, 
   I.N. Lavrik, V.A. Ivanisenko ............................... 263
SLEEP OF REASON IN THE ANALYSIS OF THE RESULTS OF RESEARCH 
ON MATERIALS «PROTEOMIC INFORMATION OFSPRING WHEAT 
VARIETIES DIFFERING IN RESISTANCE TO INFECTION AFTER 
PUCCINIA RECONDITA INOCULATION»
   K.N. Sarsenbayev, A. Sarsenbayeva .......................... 264
MODULATION OF COGNITIVE FUNCTION BY OXIDATIVE DNA BASE 
LESION REPAIR
   K. Scheffler, V. Rolseth, M.D. Bjorge, G. Hildrestrand,
   W. Wang, R. Suganthan, A. Kusnierczyk, C. Neurauter,
   H. Korvald, C. Vеgbш, L. Luna, G. Slupphaug,
   L. Eide, M. Bjoras ......................................... 265
DISEASE MODELS FOR CANCER TO SELECT CANDIDATE BIOMARKERS 
AND DRUG TARGET
   E. Schwartz, A. Yuryev, C. Ross, I. Riz, A. McPherron ...... 266
HUMAN BLOOD BISPECIFIC ANTIBODIES – NEW BIOCHEMICAL MARKERS
OF AUTOIMMUNE DISEASES
   S.E. Sedykh, V.V. Printz, V.N. Buneva, G.A. Nevinsky ....... 267
PROTEOMIC ANALYSIS OF HORSE MILK EXOSOMES
   S.E. Sedykh, L.W. Purvinsch, V.N. Buneva, G.A. Nevinsky .... 268
PHYLOGENETIC ANALYS OF DAHPS II TYPE AMINOACID SEQUENCES
   A.I. Semashko, E.G. Veremeenko, N.P. Maksimova ............. 269
TARGETED HIGH-THROUGHPUT SEQUENCING FOR MODY GENES IN WEST 
SIBERIA
   E.V. Shakhtshneider, E.N. Voropaeva, D.E. Ivanoshchuk,
   A.K. Ovsyannikova, O.D. Rymar, Y.I. Ragino, M.I. Voevoda ... 270
THE ROLE OF THE MECHANISMS OF RESISTANCE TO IONIZING 
RADIATION IN DROSOPHILA MELANOGASTER AGING AND LONGEVITY
   M.V. Shaposhnikov, E.N. Proshkina, L.A. Shilova, 
   D.O. Peregudova, S.O. Zhikrivetskaya, A.A. Moskalev ........ 271
PATTERNS AND MECHANISMS OF CHROMOSOMAL EVOLUTION INFERRED
FROM PHYSICALLY MAPPED GENOME ASSEMBLIES
   I.V. Sharakhov, G.N. Artemov, A. Peery, X. Jiang, 
   A.B. Hall, Z. Tu, A.N. Naumenko, V.N. Stegniy, 
   M.V. Sharakhova ............................................ 272
GENOME AND CHROMOSOME EVOLUTION OF MOSQUITOES – VECTORS OF
HUMAN DISEASES
   M.V. Sharakhova, V.A. Timoshevskiy, A.N. Naumenko, 
   A. Peery, G.N. Artemov, V.N. Stegniy, I.V. Sharakhov ....... 273
DISSECTING VARIANCE HETEROGENEITY IN HUMAN SERUM METABOLOME
   S.Zh. Sharapov, Y.A. Tsepilov, J.S. Ried, K. Strauch, 
   C. Gieger, Y.S. Aulchenko .................................. 274
THE MITOCHONDRIAL GENE ORDER AND CYTB EVOLUTION IN 
HYMENOPTERA AND OTHER INSECTS
   F.S. Sharko, A.V. Nedoluzhko, S.M. Rastorguev, 
   A.A. Polilov, K.G. Skryabin, E.B. Prokhortchouk ............ 275
THE INFLUENCE OF SNP RS201381696 OF A TATA BOX IN THE HUMAN
LEP GENE ON EXPRESSION OF REPORTER GENE LUC
   E.B. Sharypova,E.V. Kashina, O.V. Arkova, N.P. Bondar, 
   T.V. Arshinova, P.M. Ponomarenko, M.P. Ponomarenko, 
   L.K. Savinkova ............................................. 276
THE OCCURRENCE OF SPRING FORMS IN TETRAPLOID TIMOPHEEVI
WHEATS IS ASSOCIATED WITH VARIATION IN THE FIRST INTRON
OF VRN-A1 GENE
   A.B. Shcherban, A.A. Schischkina, E.A. Salina .............. 277
FREQUENCY OF GERMLINE MUTATIONS GENES CHEK, FANCL AND FANCI 
PATIENTS WITH BREAST CANCER IN THE REPUBLIC OF TATARSTAN
   L. Shigapova, E. Shagimardanova, O. Gusev, A. Nikitin,
   M.Gordiev .................................................. 278
IDENTIFICATION OF NUCLEAR GENES CONTROLLING CHLOROPHYLL 
SYNTHESIS IN BARLEY BY RNA-SEQ
   N.A. Shmakov, G.V. Vasiliev, N.V. Shatskaya, 
   A.V. Doroshkov, D.A. Afonnikov, E.K. Khlestkina ............ 279
NICOTIANA GENOMICS: FROM PLANTS TO GENOMES
   N. Sierro, J.N.D. Battey, S. Ouadi, N. Bakaher, 
   L. Bovet, A. Willig, S. Goepfert, M.C. Peitsch,
   N.V. Ivanov ................................................ 280
COMPARATIVE ANALYSIS OF GASTROINTESTINAL MICROBIOME IN WILD
AND DOMESTIC QUAILS
   M.N. Siniagina, M.I. Markelova, E.R. Kirillova, 
   E.A. Boulygina, A.V. Lichoman,, V.V. Radchenko ............. 281
PHYLOGENETIC ANALYSES OF MYCOBACTERIUM TUBER-CULOSIS URAL 
FAMILY BY WGS DATA FROM EURASIA
   V. Sinkov, O. Ogarkov, Y. Bukin, I. Mokrousov, 
   S. Zhdanova ................................................ 282
DEVELOPMENT OF TISSUE-ENGINEERING CELL-SEEDED CHITOSAN-
POLYCAPROLACTONE BLENDS FOR VASCULAR SURGERY
   A.M. Smirnova, I.S. Zakharova .............................. 283
DIFFERENTIAL EXPRESSION OF GLYCOLYSIS-RELATED GENES IN
HILAR CHOLANGIOCARCINOMA
   A.V. Snezhkina, D.V. Kalinin, M.S. Fedorova, 
   O.L. Kardymon, I.Y. Karpova, A.F. Sadritdinova,
   N.V. Melnikova, A.A. Belova, M.M. Belyakov, 
   O.S. Sudalenko, N.N. Volchenko, A.Y. Popov,
   K.M. Nyushko, A.D. Kaprin, B.Y. Alekseev, 
   A.A. Dmitriev, G.S. Krasnov, A.V. Kudryavtsev .............. 284
THE ROLE OF MIR-9 AND MIR-98 IN THE REGULATION OF HK2 GENE 
EXPRESSION IN COLORECTAL CANCER
   A.V. Snezhkina, I.Y. Karpova, O.L. Kardymon, 
   A.F. Sadritdinova, M.S. Fedorova, N.V. Melnikova,
   O.A. Stepanov, K.M. Klimina, E.N. Slavnova, 
   K.M. Nyushko, N.N. Volchenko, M.A. Chernichenko,
   D.V. Sidorov, D.V. Kalinin, A.Y. Popov, G.S. Krasnov, 
   A.V. Kudryavtseva .......................................... 285
ANALYSIS OF A POWERFUL CONSTITUTIVE PROMOTER IN CULTURED 
CELLS OF POLYPEDILUM VANDERPLANKI
   Y. Sogame, Y. Miyata, R. Deviatiiarov, S. Kikuta, 
   R. Cornette, O. Gusev, T. Furusawa, T. Kikawada ............ 286
DENOVO ASSEMBLY OF NUCLEAR GENOME OF THE SMALLEST INSECT 
MEGAPHRAGMA AMALPHITANUM (HYMENOPTERA: TRICHOGRAMMATIDAE)
   A.S. Sokolov, A.V. Nedoluzhko, F.S. Sharko, 
   E.S. Boulygina, S.V. Tsygankova, A.M. Mazur,
   A.A. Polilov, E.B. Prokhortchouk, K.G. Skryabin ............ 287
GENETIC CONTROL OF CIRCADIAN RHYTHMS:AN IMPACT OF MOLECULAR
CLOCK EXPRESSION PROFILE CHANGES IN LONGEVITY
   I.A. Solovev, E.V. Dobrovolskaya, A.A. Moskalev ............ 288
KYNURENIC ACID-SENSITIZED PHOTOLYSIS OF LENS PROTEINS UNDER
ANAEROBIC CONDITIONS
   E.D. Sormacheva, P.S. Sherin, E.A. Zelentsova, 
   T.G. Duzhak, Yu.P. Tsentalovich, R.Z. Sagdeev .............. 289
PARAMETER FITTING INFRASTRUCTURE FOR RULE-BASED MODELLING
   O.S. Sorokina, A.A. Sorokin ................................ 290
VIROME ANALYSIS FOR IDENTIFICATION OF VIRUSES IN BAT 
SPECIES FROM MOSCOW REGION
   A.S. Speranskaya, E.V. Pimkina, I.V. Artyushin,
   M.V. Safonova, A.A. Deviatkin, K.V. Kuleshov,
   V.G. Dedkov, G.A. Shipulin ................................. 291
EXPGENE – SOFTWARE FOR ANALYSIS AND PROCESSING OF GENE 
EXPRESSION DATA
   A.M. Spitsina .............................................. 292
PREDICTING SMALL RNAs FROM BACTERIAL GENOME
   T. Stankovic, J. Guzina, M. Nikolic, M. Djordjevic ......... 293
IDENTIFICATION OF BACILLUS PUMILUS GROUP STRAINS BY MALDI 
TOF MS USING GEOMETRIC APPROACH
   K.V. Starostin, E.A. Demidov, A.V. Bryanskaya, 
   V.M. Efimov, A.S. Rozanov, S.E. Peltek ..................... 294
CHANGES IN THE BRAIN TRANSCRIPTOME OF OXYS RATS AS THE 
SIGNS OF ALZHEIMER'S DISEASE DEVELOP AND EFFECTS OF SKQ1
   N.A. Stefanova, N.I. Ershov, N.A. Muraleva, 
   N.G. Kolosova .............................................. 295
ULTRASTRUCTURAL ANALYSIS OF MITOTIC DIVISION IN DROSOPHILA 
S2 CELLS
   A.A. Strunov, L.V. Boldyreva, A.V. Pindyurin, M. Gatti, 
   E. Kiseleva ................................................ 296
ULTRASTRUCTURAL ANALYSIS OF SPINDLE AND KINETOCHORES IN 
AUGMIN-DEPLETED DROSOPHILA S2 CELLS
   A.A. Strunov, L.V. Boldyreva, A.V. Pindyurin, M. Gatti, 
   E. Kiseleva ................................................ 297
MYC GENE FAMILY IN CEREALS: TRANSFORMATION IN THE COURCE OF
THE TRITICUM AND AEGILOPS GENERA EVOLUTION
   K.V. Strygina, E.K. Khlestkina ............................. 298
IN SILICO MODELLING OF EXPERIMENTAL ChIP-Seq PROCESS
   T. Subkhankulova, F.M. Naumenko, Y.L. Orlov ................ 299
SINGLE CELL EXPRESSION PROFILING OF NEURAL CREST-DERIVED
CELLS
   T. Subkhankulova, G. Aquino, A. Rocco, H. Schwetlick, 
   R.N. Kelsh ................................................. 300
MOLECULAR PHYLOGENETIC ANALYSIS OF THE GRASSHOPPERS OF
FAMILY ACRIDIDAE BASED ON SEVERAL MITOCHONDRIAL AND NUCLEAR 
MARKERS
   I.S. Sukhikh, A.G. Blinov, A.G. Bugrov ..................... 301
COMPREHENSIVE ANALYSIS OF DRAFT GENOMES OF TWO CLOSELY 
RELATED PSEUDOMONAS SYRINGAE PHYLOGROUP 2B STRAINS 
INFECTING MONO- AND DICOTYLEDON HOST PLANTS
   R.I. Sultanov, G.P. Arapidi, S.V. Vinogradova, 
   V.M. Govorun, D.G. Luster,A.N. Ignatov ..................... 302
ADAPTATION AND BIOLOGICAL TIME
   V.V. Suslov ................................................ 303
TATA-BOX AND GENE EXPRESSION NORM OF REACTION
   V.V. Suslov, M.P. Ponomarenko, D.A. Rasskazov .............. 304
VAVILOV'S HOMOLOGOUS SERIES AS EVOLUTIONARY FORCE
   V.V. Suslov, M.P. Ponomarenko, D.A. Rasskazov .............. 305
IDENTIFICATION OF PATHWAYS ASSOCIATED WITH CELL DEATH IN 
THE CORTEX OF OXYS RATS AS THE SIGNS OF ALZHEIMER'S DISEASE 
DEVELOP
   G.K. Suvorov, D.V. Telegina, E.A. Rudnitskaya, 
   N.A. Stefanova, N.G. Kolosova .............................. 306
GENETIC POLYMORPHISM OF GLUTATHIONE S-TRANSFERASE P1 (GSTP1)
AMONG BURYATS, TELEUTS AND RUSSIANS
   L.E. Tabikhanova, L.P. Osipova, T.V. Churkina, 
   H. Bai, E.N. Voronina, M.L. Filipenko ...................... 307
THE ILE462VAL POLYMORPHISM OF THE CYTOCHROME P450 CYP1A1 
GENE AMONG EASTERN BURYATS COMPARED WITH RUSSIANS IN TRANS
BAIKAL AREA
   L.E. Tabikhanova, L.P. Osipova, T.V. Churkina, 
   E.N. Voronina, M.L. Filipenko .............................. 308
COMPUTER MODELLING OF INHIBITORS OF PROTEASE OF HUMAN
HEPATITIS C VIRUS BASED ON KNOTTIN SCAFFOLD
   A.V. Talanova, D.S. Shcherbinin, E.F. Kolesanova,
   A.V. Veselovsky ............................................ 309
THE STRUCTURE OF GENETIC PREDISPOSITION TO TYPE 1 AND TYPE
2 DIABETES
   N.V. Tarasenko, I.A. Goncharova, A.V. Markov,
   V.P. Puzyrev ............................................... 310
FIGHTING WITH HIV-1 RESISTANCE TO REVERSE TRANSCRIPTASE 
INHIBITORS BY COMPUTER-AIDED APPROACH
   O.A. Tarasova, D.A. Karasev, D.A. Filimonov, 
   V.V. Poroikov .............................................. 311
NUCLEOTIDE DIVERSITY ANALYSIS HIGHLIGHTS FUNCTIONALLY 
IMPORTANT GENOMIC REGIONS
   T.V. Tatarinova, E. Chekalin, Y. Nikolsky, S. Bruskin, 
   D. Chebotarov, K.L. McNally, N. Alexandrov ................. 312
RELATIONSHIP OF CELL DEATH IN RETINA OF RATS DURING AGING 
WITH THE DEVELOPMENT OF RETINOPATHY
   D.V. Telegina, O.S. Kozhevnikova, N.G. Kolosova ............ 313
SANGER DATA PROCESSING IN UNIPRO UGENE
   A.V. Tiunov, E.A. Pushkova, Y.A. Algaer, G.A. Grekhov ...... 314
GENETIC BASIS OF AGGRESSION: CLUSTERIZATION OF EXPRESSION 
PROFILES
   E.S. Tiys, A.O. Bragin, I.V. Medvedeva, I.V. Chadaeva,
   A.L. Markel, Y.L. Orlov .................................... 315
GENEONTOLOGY BIOLOGICAL PROCESSES SENSITIVE TO SALT DIET 
CHANGES IN AN EXPREIMENT WITH 105-DAY ISOLATION:
STATISTICAL ANALYSIS OF URINE PROTEOME
   E.S. Tiys, E.D. Petrovskiy, L.Kh. Pastushkova, 
   D.N. Kashirina, I.M. Larina, V.A. Ivanisenko ............... 316
PHSYOLOGICAL AND TRANSCRIPTIONAL CHANGES IN A BLOSSAM-END 
ROT RESISTANT TOMATO INTROGRESSION LINE IL8-3 FRUIT
   S. Tomoki, H. Ikeda, Y. Kanayama ........................... 317
DIFFERENTIAL EXPRESSION OF SHAGGY, A DROSOPHILA 
MELANOGASTER GENE ENCODING GSK-3 BETA, AFFECTS LIFESPAN
   M.V. Trostnikov, N.V. Roshina, E.G. Pasyukova .............. 318
ADDITIVITY AND NON-ADDITIVITY OF GENETIC CONTROL OF HUMAN 
METABOLOME
   Y.A. Tsepilov, S. Shin, N. Soranzo, T.D. Spector, 
   J. Adamski, G. Kastenmьller, K. Strauch, R. Wang-Sattler,
   C. Gieger, Y.S. Aulchenko, J.S. Ried ....................... 319
IDENTIFICATION OF BREED-SPECIFIC SNP-MARKERS FOR SUS SCROFA 
DOMESTICUS USING SRA-DATA OF NGS PROJECTS
   I.S. Tsybovsky, V.N. Kipen, S.A. Kotova .................... 320
IDENTIFICATION OF THE TAXA OF THE ORDER ARTIODACTYLA FOR 
CRIMINAL INVESTIGATION CASES OF ILLEGAL HUNTING
   I.S. Tsybovsky, S.A. Kotova, V.I. Rybakova,
   A.A. Rabcava, E.A. Spivak .................................. 321
MOLECULAR EVOLUTION OF YUCCA PROTEIN FAMILY
   I.I. Turnaev, V.V. Suslov, K.V. Gunbin, D.A. Afonnikov ..... 322
LOOKING FOR PROTEOMIC MARKERS OF BREAST CANCER IN BLOOD
EXOSOMES
   O.S. Tutanov, S.N. Tamkovich, Y.S. Bakakina, 
   L.V. Dubovskaya, Y.P. Tsentalovich, I.D. Volotovskiy,
   P.P. Laktionov ............................................. 323
MITOCHONDRIAL DYSFUNCTION IN SPORADIC ALZHEIMER'S DISEASE-
LIKE PATHOLOGY IN OXYS RATS
   M.A. Tyumentsev, E.V. Kiseleva, V.A. Vavilin, 
   N.G. Kolosova, N.A. Stefanova .............................. 324
REGULATION OF RIPKS IN CELL SURVIVAL AND CELL DEATH BY 
APOPTOSIS AND NECROPTOSIS, INSIGHTS AND THERAPEUTIC 
POTENTIAL
   P. Vandenabeele ............................................ 325
MUTATIONS SPECTRA OF MAJOR ONCOGENES IN PATIENTS WITH 
MULTIPLE PRIMARY NEOPLASIA
   G.V. Vasiliev, A.V. Savkova, A.V. Gerasimov ................ 326
PARASITES OF THE GENERA NOSEMA, APICISTIS, CRITHIDIA AND
LOTMARIA IN THE NATURAL HONEYBEE AND BUMBLEBEE POPULATIONS:
A CASE STUDY IN INDIA
   V. Vavilova, I. Konopatskaia, M. Woyciechowski, 
   S. Luzianin, A. Blinov ..................................... 327
EFFECTS OF LAMBERTIANIC ACID AMIDE ON EPILEPTIFORM ACTIVITY 
IN HIPPOCAMPAL SLICES INDUCED BY PICROTOXIN OR MAGNESIUM-
FREE MEDIUM
   S.O. Vechkapova, A.L. Proskura, T.A. Zapara, 
   E.D. Sorokoumov, A.S. Ratushnyak ........................... 328
ARGO_CUDA: A FULL-EXHAUSTIVE GPU BASED APPROACH FOR A MOTIF 
DISCOVERY IN THE LARGE DNA DATASETS
   O.V. Vishnevsky, A.V. Bocharnikov, N.A. Kolchanov .......... 329
THE IMPACT OF HUMAN GENETIC VARIABILITY ON LIGAND-PROTEIN 
INTERACTIONS AND INDIVIDUAL DRUG RESPONSE
   P.K. Vlasov, O. Pich I Rosello, A.V. Vlasova, 
   F.A. Kondrashov ............................................ 330
CHARACTERISTICS OF ACDS-GENE OF BACTERIA PSEUDOMONAS PUTIDA 
B-37 RESPONSIBLE FOR ACC-DEAMINASE SYNTHESIS
   D.S. Volkava, S.I. Leanovich, A.A. Melnikava, 
   E.A. Khramtsova ............................................ 331
AmpliSeqTM: AMPLIFICATION AND SEQUENCING
   I.A. Volkov ................................................ 332
COUPLED MOLECULAR DYNAMIC AND CONTINUUM ELECTROSTATIC 
METHOD TO COMPUTE IONIZATION OF PROTEINS AS A FUNCTION OF 
PH
   Yu.N. Vorobjev ............................................. 333
METHODS TO CALCULATE P-VALUE OF RNA OF A DEFINITE SHAPE
   D.G. Vorobyev, V.V. Solovyev ............................... 334
HOCOMOCO COMPREHENSIVE MODEL COLLECTION AS A PRACTICAL 
GATEWAY TO REGULATORY MOTIF-OME OF HUMAN AND MOUSE 
TRANSCRIPTION FACTORS
   I.E. Vorontsov, Y.A. Medvedeva, V.J. Makeev, 
   I.V. Kulakovskiy ........................................... 335
THE FREQUENCY, SPECTRUM AND FUNCTIONAL SIGNIFICANCE OF 
MUTATIONS IN CODING SEQUENCE OF TP53 GENE IN RUSSIAN 
PATIENTS WITH DLBCL
   E.N. Voropaeva, T.I. Pospelova, M.I. Voevoda, 
   V.N. Maximov ............................................... 336
HOW SEQUENCE AND STRUCTURE AFFECT THE MIRNA MATURATION
   P.S. Vorozheykin, I.I. Titov ............................... 337
DRAFT GENOME SEQUENCE OF STREPTOMYCES SP. IB 2014 011-1 
ISOLATED FROM LAKE BAIKAL MACROINVERTEBRATES
   I.V. Voytsekhovskaya, D.V. Axenov-Gribanov, 
   B.T. Tokovenko, Y.V. Rebets, E.S. Protasov, 
   A.N. Luzhetskyy, M.A. Timofeyev ............................ 338
ACTUAL APPROACHES FOR QUALIFICATION AND QUANTIFICATION OF 
PROTEOME CHANGES
   E.P. Vrzheschch ............................................ 339
MULTIDIMENSIONAL PATTERNS OF METABOLIC RESPONSE IN ABIOTIC 
STRESS-INDUCED GROWTH OF ARABIDOPSIS THALIANA
   B.S. Yadav, S. Freilich, E. Katz, A. Finkelshtein, 
   D.A. Chamovitz ............................................. 340
Optimization of the piggyBac transposon system for cultured
Drosophila cells
   L.A. Yarinich, M.O. Lebedev, A.V. Pindyurin ................ 341
GTRD – GENE TRANSCRIPTION REGULATION DATABASE
   I.S. Yevshin, R.N. Sharipov, Yu.V. Kondrakhin, 
   F.A. Kolpakov .............................................. 342
ASSESSMENT OF TRANSLATION EFFICENCY FROM RIBOSOME PROFILING 
AND MRNA-SEQ DATA
   I.S. Yevshin, R.N. Sharipov, O.A. Volkova .................. 343
STRUCTURAL BIOINFORMATICS OF FPG GLYCOSYLASE: SEARCH FOR 
SUBSTRATE SPECIFICITY IN THE SEQUENCE SPACE
   A.V. Yudkina ............................................... 344
IN SILICO DESIGN OF APTAMERS CONTAINING G-QUADRUPLEXES
   A.O. Zalevsky, A.O. Demkiv, A.V. Golovin ................... 345
DISTINCT TYPES OF EIN3-DNA INTERACTIONS IN VARIOUS 
FUNCTIONAL REGIONS OF A. THALIANA L. GENOME
   E.V. Zemlyanskaya, D.Yu. Oshchepkov, V.G. Levitsky ......... 346
ELEMENTAL METABOLOMICS – LINKING ENVIRONMENTAL, FOOD,
NUTRITION AND HEALTH SCIENCES
   P. Zhang, I. Giannenas, C.A. Georgiou, V. Brusic ........... 347
SPEED READING AT THE MOLECULAR SCALE: HOW ENZYMES FIND 
TYPOS IN A DNA TEXT
   D.O. Zharkov ............................................... 348
PHYLOGENETIC RECONSTRUCTION WITHIN MYCOBACTERIUM 
TUBERCULOSIS BEIJING GENOTYPE IN NORTHEASTERN RUSSIA
   S. Zhdanova, O. Ogarkov, G. Alexeeva, M. Vinikurova, 
   E. Savilov, V. Sinkov ...................................... 349
CHEMORESISTANCE OF LUNG ADENOCARCINOMA IS REGULATED BY 
TUDOR STAPHYLOCOCCAL NUCLEASE
   B. Zhivotovsky ............................................. 350
COMPUTER SIMULATION OF TRICHOME PATTERNING ON GROWING WHEAT 
LEAF TAKING INTO ACCOUNT THE BIOMECHANICS OF CELLS
   U.S. Zubairova, S.V. Nikolaev, A.V. Penenko, 
   N.L. Podkolodnyy, S.K. Golushko,
   D.A. Afonnikov, N.A. Kolchanov ............................. 351
AN IMAGEJ PLUGIN FOR DETECTION OF WHEAT LEAF EPIDERMIS 
CELLULAR STRUCTURE FROM CONFOCAL LASER SCANNING MICROSCOPY
   U.S. Zubairova, P.Yu. Verman, A.V. Doroshkov ............... 352
ALTORFEV: A NOVEL TOOL FOR PREDCITION OF ALTERNATIVE ORFS 
BASED ON THE LINEAR SCANNING MODEL
   B.S. Zuraev, A.V. Kochetov, A.I. Klimenko, S.A. Lashin ..... 353

Author index .................................................. 354