List of Contributors ........................................... ix
1 Introduction ................................................. 1
Jerome O. Nriagu and Eric P. Skaar
Host-Microbe Interactions: The Microbe Perspective
2 Is Metal Uptake Related to Ecological Niche
in the Vertebrate Host? ..................................... 13
Joseph Lemire, Trevor F. Moraes, Vahid Fa Andisi, and
Anthony B. Schryvers
3 Competition for Metals among Microbes and Their Host ........ 29
Michael A. Bachman and Jeffrey N. Weiser
4 The Fate of Intracellular Metal Ions in Microbes ............ 39
Slade A. Lou tet, Anson С.K. Chan, Marek J. Kobylarz,
Meghan M. Verstraete, Stephanie Pfaffen, Bin Ye,
Angel L. Arrieta, and Michael E.P. Murphy
5 Common Mechanisms of Bacterial Metal Homeostasis ............ 57
James A. Imlay
6 Intervention Strategies for Metal Deficiency and Overload ... 83
Fudi Wang and Li hong Zhang
7 Trace Metals in Host-Microbe Interactions: The Microbe
Perspective ................................................. 99
Jennifer S. Cavet, Robert D. Perry, Sascha Brunke,
K. Heran Darwin, Carol A. Fierke, James A. Imlay,
Michael E.P. Murphy, Anthony B. Schryvers, Dennis
J. Thiele, and Jeffrey N. Weiser
Host-Microbe Interactions: The Host Perspective
8 Metal Homeostasis during Development, Maturation, and
Aging: Impact on Infectious Diseases ....................... 125
Inga Wessels
9 Impact of Metals on Immune Response and Tolerance, and
Modulation of Metal Metabolism during Infection ............ 147
Günter Weiss
10 Metal-Based Antiparasitic Therapeutics ..................... 161
Maribel Navarro and Gonzalo Visbal
11 Impact of Lifestyle on Metal Exposure, Homeostasis, and
Associated Diseases ........................................ 173
George V. Dedoussis
12 Obesity, Trace Metals, and Infection ....................... 185
Jerome O. Nriagu
13 Metals in Host-Microbe Interaction: The Host Perspective ... 199
Dieter Rehden Robert E. Black, Julia Bornhorst, Rodney
R. Dietert, Victor J. DiRita, Maribel Navarro, Robert
D. Perry, Lothar Rink, Eric P. Skaar, Miguel С.P. Soares,
Dennis J. Thiele, Fudi Wang, Günter Weiss, and Inga
Wessels
Metals in the Environment as Risk Factors for Infectious
Diseases
14 Selenium and Mercury: Their Interactions and Roles in
Living Organisms ........................................... 229
Tamara García-Barrera
15 New Technologies Using Trace Metals of Concern ............. 239
Jozef M. Pacyna, Kyrre Sundseth, and Elisabeth G. Pacyna
16 The Promise of Nanometals: Reducing Infection and
Increasing Biocompatibility ................................ 257
Mian Wang, Wenwen Liu, and Thomas J. Webster
17 Metals in the Environment as Risk Factors for Infectious
Diseases: Gaps and Opportunities ........................... 271
M. Leigh Ackland, Julia Bornhorst, George V. Dedoussis,
Rodney R. Dietert, Jerome O. Nriagu, Jozef M. Pacyna,
and John M. Pettifor
Methods and Technologies for Analyzing Trace Metals in
Biological Systems
18 Emerging Strategies in Metalloproteomics ................... 311
Peter-Leon Hagedoorn
19 Measuring Metals in Complex Biological Systems ............. 323
Andreas Matusch, Ana-Maria Oros-Peusquens, and J. Sabine
Becker
20 Methods and Technologies for Studying Metals in
Biological Systems ......................................... 341
Wolfgang Maret, Joseph A. Caruso, Christopher H. Contag,
David P. Giedroc, Peter-Leon Hagedoorn, Andreas Matusch,
Eric P. Skaar, and Richard B. Thompson
List of Acronyms .............................................. 403
Bibliography .................................................. 407
Subject Index ................................................. 477
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