Part I. Immune Activation, Suppression and Manipulation of
the Immune Antitumor Response
Myeloid-Derived Suppressor Cells in Cancer ...................... 3
Christos E. Kyriakopoulos, Alberto J. Monterao, and Claudia
Marcela Diaz-Montero
The Role of В Cells in Shaping the Antitumor Immune Response ... 19
Yu Zhang, Taylor H. Schreiber, and Joseph D. Rosenblatt
Heat-Shock Protein-Based Cancer Immunotherapy .................. 37
Taylor H. Schreiber
Activation of NK Cell Responses and Immunotherapy of Cancer .... 57
George J. Weiner
Induction of Tumor Immunity by Targeted Inhibition
of Nonsense-Mediated mRNA Decay ................................ 67
Eli Gilboa
Employing T Cell Homeostasis as an Antitumor Strategy .......... 83
Shawn M. Jensen, Christopher C. Paustain, and Bernard A. Fox
Adoptive Cell Therapy of Systemic Metastases Using erbB-2-
Specific T Cells Redirected with a Chimeric Antibody-Based
Receptor ...................................................... 107
Dinorah Friedmann-Morvinski, Tova Waks, Assaf Marcus, and
Zelig Eshhar
Part II. Evolving Clinical Immunotherapeutic Strategies
Immunotherapy in Renal Cell Carcinoma ......................... 125
Jennifer Cudris and Jaime R. Merchan
Adoptive T-Cell Transfer as a Clinical Antitumor Strategy
for Hematologic Malignancies .................................. 149
Aaron P. Rapoport and Nadia Ijaz
Bifunctional Antibodies: Preclinical and Clinical
Applications .................................................. 183
Casey W. Shuptrine and Louis M. Weiner
Clinical Development of Antibody-Fusion Proteins for Cancer
Therapy ....................................................... 213
Kory L. Alderson, Amy K. Erbe, Margaret Boyden, and Paul
M. Sondel
Immunologic Outcomes of Allogeneic Stem Cell Transplantation:
Graft-Versus-Host and Graft-Versus-Leukemia Responses
and Implications for Future Therapy ........................... 237
Lazaros J. Lekakis and Krishna V. Komanduri
The Immune System in Head and Neck Squamous Cell Carcinoma:
Interactions and Therapeutic Opportunities .................... 275
Paolo Serafini and Donald T. Weed
T Cell Co-regulatory Signals and Their Role in Cancer
Therapy ....................................................... 323
Eitan R. Friedman, Lynn Feun, Pasquale Benedetto, and Joseph
D. Rosenblatt
Assessment of Immune Response in Biotherapy Trials and
Clinical Endpoints ............................................ 343
Theresa L. Whiteside
Index ......................................................... 365
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