Preface ....................................................... vii
DNA Base Damage by Reactive Oxygen Species, Oxidizing
Agents, and UV Radiation ........................................ 1
Jean Cadet and J. Richard Wagner
Ancient DNA Damage ............................................. 19
Jesse Dabney, Matthias Meyer, and Svante Pääbo
DNA Repair by Reversal of DNA Damage ........................... 27
Chengqi Yi and Chuan He
Base Excision Repair ........................................... 45
Hans E. Krokan and Magnar Bjørås
Prokaryotic Nucleotide Excision Repair ......................... 67
Caroline Kisker, Jochen Kuper, and Bennett Van Houten
Nucleotide Excision Repair in Eukaryotes ....................... 85
Orlando D. Schärer
Mammalian Transcription-Coupled Excision Repair ............... 105
Wim Vermeulen and Maria Fousteri
Alternative Excision Repair Pathways .......................... 121
Akira Yasui
Postreplicative Mismatch Repair ............................... 129
Josef Jiricny
The Maintenance of Mitochondrial DNA Integrity - Critical
Analysis and Update ........................................... 153
Mikhail Alexeyev, Inno Shokolenko, Glenn Wilson, and
Susan LeDoux
Nucleosome Dynamics as Modular Systems that Integrate DNA
Damage and Repair ............................................. 171
Craig L. Peterson and Genevieve Almouzni
DNA Damage Response: Three Levels of DNA Repair Regulation .... 183
Bianca M. Sirbu and David Cortez
DNA Damage Responses in Prokaryotes: Regulating Gene
Expression, Modulating Growth Patterns, and Manipulating
Replication Forks ............................................. 199
Kenneth N. Kreuzer
DNA Damage Sensing by the ATM and ATR Kinases ................. 223
Alexandre Maréchal and Lee Zou
Repair of Strand Breaks by Homologous Recombination ........... 241
Maria Jasin and Rodney Rothstein
Repair of Double-Strand Breaks by End Joining ................. 259
Kishore K. Chiruvella, Zhuobin Liang, and Thomas E. Wilson
DNA Repair at Telomeres: Keeping the Ends Intact .............. 281
Christopher J. Webb, Yun Wu, and Virginia A. Zakian
Translesion DNA Synthesis and Mutagenesis in Prokaryotes ...... 309
Robert R Fuchs and Shingo Fujii
Replicating Damaged DNA in Eukaryotes ......................... 331
Nimrat Chatterjee and Wolfram Siede
Translesion DNA Synthesis and Mutagenesis in Eukaryotes ....... 351
Julian E. Sale
Adventures in Understanding the Complex Mechanisms of DNA
Interstrand Cross-Link Repair ................................. 373
Cheryl Clausen, Orlando D. Schärer, and Laura Niedernhofer
Biology of Extreme Radiation Resistance: The Way of
Deinococcus radiodurans ....................................... 399
Anita Krisko and Miroslav Radman
Diseases Associated with Defective Responses to DNA Damage .... 411
Mark O'Driscoll
Index ......................................................... 437
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