Lutz Vollrath
Foreword ........................................................ 5
Sigurd Lenzen
Hundred years of glycolysis research with special emphasis
upon the mechanisms of regulation of this pathway .............. 11
Annette Schürmann
The pathophysiology of type 2 diabetes ......................... 16
Anne Jörns
Identification of beta cells and cytokine pattern in
pancreatic islets after type 1 and type 2 diabetes
manifestation .................................................. 21
Insa S. Schroeder
Stem cell research in experimental diabetology ................. 27
Thomas Hammer
Diabetic ophthalmopathies ...................................... 38
Elmar Peschke, Dorothee Peschke and Eckhard Mühlbauer
Melatonin-insulin-interactions ................................. 45
Ina Bähr, Eckhard Mühlbauer and Elmar Peschke
Influence of melatonin on glucagon secretion ................... 68
Juliane Zibolka, Eckhard Mühlbauer and Elmar Peschke
The human somatostatinoma cell line QGP-1 as a model for
functional, melatonin-responsive islet δ-cells ................. 73
Elke Albrecht, Eckhard Mühlbauer, Ivonne Bazwinsky-Wutschke
and Elmar Peschke
Influence of the MT1 receptor on insulin secretion of rat
insulinoma β-cell (LNS1) and isolated mouse pancreatic
islets ......................................................... 79
Eckhard Mühlbauer, Elke Albrecht, Kathleen Biemann,
Ivonne Bazwinsky-Wutschke and Elmar Peschke
Heterologous expression of the human melatonin receptor MT2
and its functional importance in the rat insulinoma β-cell
line INS1 ...................................................... 85
Ivonne Bazwinsky-Wutschke, Eckhard Mühlbauer and Elmar
Peschke
Calcium signaling components and phosphorylation of cyclic
AMP-response element-binding protein (CREB) are influenced
by melatonin in pancreatic β-cells ............................. 89
Ina Bähr, Eckhard Mühlbauer and Elmar Peschke
Influence of melatonin on the cGMP signaling pathway in
pancreatic β-cells ............................................ 101
Eckhard Mühlbauer and Elmar Peschke
Clock genes and the pancreatic islets of Langerhans ........... 106
Kathleen Biemann, Ulrike Schönerstedt, Elke Albrecht,
Eckhard Mühlbauer and Elmar Peschke
Influence of insulin on the hepatic diurnal expression of
clock genes and clock-controlled genes in spontaneous type 1
diabetic rats ................................................. 116
Ulrike Schönerstedt, Kathleen Biemann, Sabine Wolgast,
Eckhard Mühlbauer and Elmar Peschke
Aging-associated changes in the rhythmic gene expression
profile of streptozotocin-induced diabetic rat liver .......... 121
Hans-Jürgen Brömme, Katharina Klöditz and Elmar Peschke
In vitro interactions of hydroxyl radicals with melatonin
and other cellular compounds .................................. 126
Abbreviations ................................................. 137
Authors ....................................................... 139
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