Phosphatase modulators / ed by J.L.Millan. - New York: Humana press/Springer Science+Business Media, 2013. - x, 315 p.: ill. - (Methods in molecular biology; 1053) (Springer protocols). - Bibliogr. at the end of the chapters. - Ind.: p.307-315. - ISBN 978-1-62703-561-3; ISSN 1064-3745  Место хранения:   02 | Отделение ГПНТБ СО РАН | Новосибирск

Оглавление / Contents

Preface ......................................................... v Contributors ................................................... ix 1 Chemical Probe Development Versus Drug Development ........... 1 Michael R. Jackson 2 Phosphatase High-Throughput Screening Assay Design and Selection .................................................... 7 Eduard A. Sergienko 3 Multisystemic Functions of Alkaline Phosphatases ............ 27 René Buchet, José Luis Millán, and David Magne 4 Robotic Implementation of Assays: Tissue-Nonspecific Alkaline Phosphatase (TNAP) Case Study ...................... 53 Thomas D.Y. Chung 5 Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP): From Hits to Leads .................................. 85 Peter Teriete, Anthony B. Pinkerton, and Nicholas D.P. Cosford 6 A Method for Direct Assessment of Tissue-Nonspecific Alkaline Phosphatase (TNAP) Inhibitors in Blood Samples .... 103 Eduard A. Sergienko, Qing Sun, and Chen-Ting Ma 7 Isolation and Characteristics of Matrix Vesicles ........... 115 René Buchet, Slawomir Pikula, David Magne, and Saïda Mebarek 8 The Use of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 Inhibitors to Affect Mineralization by Cultured Cells ............................................. 125 Tina Kiffer-Moreira and Sonoko Narisawa 9 Modulators of Intestinal Alkaline Phosphatase .............. 135 Ekaterina V. Bobkova, Tina Kiffer-Moreira, and Eduard A. Sergienko 10 New Activity Assays for ENPP1 with Physiological Substrates ATP and ADP ..................................... 145 Chen-Ting Ma and Eduard A. Sergienko 11 Structure of Acid Phosphatases ............................. 155 César L. Araujo and Pirkko T. Vihko 12 Purification of Prostatic Acid Phosphatase (PAP) for Structural and Functional Studies .......................... 167 Annakaisa M. Herrala, Ileana B. Quintero, and Pirkko T. Vihko 13 Protein Tyrosine Phosphatases: Structure, Function, and Implication in Human Disease ............................... 179 Lutz Tautz, David A. Critton, and Stefan Grotegut 14 High-Throughput Screening for Protein Tyrosine Phosphatase Activity Modulators ............................ 223 Lutz Tautz and Eduard A. Sergienko 15 Evaluating Effects of Tyrosine Phosphatase Inhibitors on T Cell Receptor Signaling ............................... 241 Souad Rahmouni, Laurence Delacroix, Wallace H. Liu, and Lutz Tautz 16 Interactor-Guided Dephosphorylation by Protein Phosphatase-1 .............................................. 271 Shannah Boens, Kathelijne Szekér, Aleyde Van Eynde, and Mathieu Bollen 17 Structure, Regulation, and Pharmacological Modulation of PP2A Phosphatases ....................................... 283 Caroline Lambrecht, Dorien Haesen, Ward Sents, Elitsa Ivanova, and Veerle Janssens Index ......................................................... 307