Contributors .................................................. vii
Preface ........................................................ xi
Section 1 Introduction ......................................... 1
1 Stem Cell Sources and Their Potential for Cancer
Therapeutics ................................................. 3
Khalid Shah
Section 2 Migration and Fate of Stem Cells .................... 11
2 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural
Precursor Cell Migration .................................... 13
Moneeb Ehtesham, Elliot Min, and Rebecca Kasl
3 Tumor Tropism of Mesenchymal Stem Cells ..................... 21
Paula Y.P. Lam and Ivy A.W. Ho
Section 3 Stem Cell Therapy in Brain Cancer ................... 39
4 Stem Cell-Mediated TRAIL Therapy for Highly Aggressive
Brain Tumors ................................................ 41
Khalid Shah
5 Stem Cell-Mediated Prodrug Gene Therapy of High-Grade
Brain Tumors ................................................ 57
Cestmir Altaner
6 Role of Naive Cord Blood Stem Cells in Glioma
Therapy ..................................................... 73
Venkata Ramesh Dasari, Kiran Kumar Velpula, and Jasti
S. Rao
7 Stem Cell-Based Antiangiogenic Therapies for Brain Tumors ... 87
Navid Redjal and Khalid Shah
8 Treatment of Metastatic Neuroblastoma with Mesenchymal
Stem Cell-Based Oncolytic Virotherapy ...................... 103
Manuel Ramírez and Javier García-Castro
Section 4 Stem Cell Therapy in Other Cancer Types ............ 111
9 Umbilical Cord Matrix Stem Cells for Cytotherapy of
Breast Cancer .............................................. 113
Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu
Ishiguro, Deryl Troyer, and Masaaki Tamura
10 Mesenchymal Stromal Cells as Effective Tumor Antigen-
Presenting Cells in Cancer Therapeutics .................... 127
Raphaëlle Romieu-Mourez and Jacques Galipeau
11 Diagnostic and Therapeutic Mesenchymal Stem Cells for
Breast Cancer Treatment .................................... 145
Róisín Dwyer
12 Genetically Engineered Stem Cell Therapies Targeting
Gastrointestinal Malignancy ................................ 159
Emily Keung, Peter J. Nelson, and Claudius Conrad
13 Mesenchymal Stem Cells in Prostate Cancer: Clinical
Opportunities .............................................. 171
Diptiman Chanda and Selvarangan Ponnazhagan
14 Primed Mesenchymal Stromal Cells for Cancer Therapy ........ 187
Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto
Pallini, and Giulio Alessandri
Section 5 Combinatorial Stem Cell Therapies .................. 203
15 MicroRNA Adjuvants in Stem Cell-Based Cancer Therapy ....... 205
Maarten С.J. Anderegg and Maarten F. Corsten
16 Stem Cell-Based Combination Therapies for Cancer:
Systemic Delivery of a PI3K/mTOR Inhibitor (PI-103) and
Stem Cell-Mediated Delivery of TRAIL in Brain Tumors ....... 219
Tugba Bagci-Onder
17 The Efficacy of Clinically Approved Agents with Stem
Cell-Delivered Therapeutics for Cancer Therapy ............. 235
Hiroaki Wakimoto and Khalid Shah
Section 6 Tracking Stem Cells and Stem Cell-Based
Therapeutics .................................................. 245
18 Imaging Migration and Fate of Stem Cells in
Experimental Models of Cancer .............................. 247
Deepak Bhere and Khalid Shah
19 Multifunctional Molecules for Interrogating Stem Cell-
Based Therapeutics ......................................... 257
Shawn Hingtgen
20 Tracking Cancer-Targeted MSC with PET Imaging .............. 273
Veronique Roelants and Jean-Louis Vanoverschelde
Index ......................................................... 289
Color plate is located between pages 244 and 245.
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