Part I Chembiomolecular Chemistry
Chemistry of Mycolactones, the Causative Toxins of Buruli
Ulcer ........................................................... 3
Yoshito Kishi
Practical Synthesis of Tamiflu and Beyond ...................... 15
Motomu Kanai
An Approach Toward Identification of Target Proteins of
Maitotoxin Based on Organic Synthesis .......................... 23
Tohru Oishi, Keiichi Konoki, Rie Tamate, Kohei Torikai,
Futoshi Hasegawa, Takeharu Nakashima, Nobuaki Matsumori, and
Michio Murata
Inhibitors of Fatty Acid Amide Hydrolase ....................... 37
Dale L. Boger
Small Molecule Tools for Cell Biology and Cell Therapy ......... 51
Motonari Uesugi
Toward the Discovery of Small Molecules Affecting RNA
Function ....................................................... 59
Shiori Umemoto, Changfeng Hong, Jinhua Zhang, Takeo Fukuzumi,
Asako Murata, Masaki Hagihara, and Kazuhiko Nakatani
New Insights from a Focused Library Approach Aiming at
Development of Inhibitors of Dual-Specificity Protein
Phosphatases ................................................... 69
Go Hirai, Ayako Tsuchiya, and Mikiko Sodeoka
The Deep Oceans as a Source for New Treatments for Cancer ...... 83
William Fenical, James J. La Clair, Chambers C. Hughes,
Paul R. Jensen, Susana P. Gaudêncio, and John B. MacMillan
Search for New Medicinal Seeds from Marine Organisms ........... 93
Motomasa Kobayashi, Naoyuki Kotoku, and Masayoshi Arai
Identification of Protein-Small Molecule Interactions by
Chemical Array ................................................ 103
Hiroyuki Osada and Siro Simizu
Part II Chembiomolecular Biology
Small Molecule-Induced Proximity .............................. 115
Fu-Sen Liang and Gerald R. Crabtree
High-Throughput Screening for Small Molecule Modulators of
FGFR2-IIIb Pre-mRNA Splicing .................................. 127
Erik S. Anderson, Peter Stoilov, Robert Damoiseaux, and
Douglas L. Black
Identification of Signaling Pathways That Mediate Dietary
Restriction-Induced Longevity in Caenorhabditis elegans ....... 139
Masaharu Uno, Sakiko Honjoh, and Eisuke Nishida
Roles for the Stress-Responsive Kinases ASK1 and ASK2 in
Tumorigenesis ................................................. 145
Miki Kamiyama, Takehiro Sato, Kohsuke Takeda, and Hidenori
Ichijo
Tailored Synthetic Surfaces to Control Human Pluripotent
Stem Cell Self-Renewal ........................................ 155
Laura L. Kiessling
Cell-Surface Glycoconjugates Controlling Human T-Lymphocyte
Homing: Implications for Bronchial Asthma and Atopic
Dermatitis .................................................... 167
Reiji Kannagi, Keiichiro Sakuma, and Katsuyuki Ohmori
Establishment of a Novel System for Studying the Syk
Function in В Cells ........................................... 177
Tomohiro Kurosaki and Clifford A. Lowell
Visual Screening for the Natural Compounds
That Affect the Formation of Nuclear Structures ............... 183
Kaya Shigaki, Kazuaki Tokunaga, Yuki Mihara, Yota Matsuo,
Yamato Kojimoto, Hiroaki Yagi, Masayuki Igarashi, and Tokio
Tani
Versatile Orphan Nuclear Receptor NR4A2 as a Promising
Molecular Target for Multiple Sclerosis and Other Autoimmune
Diseases ...................................................... 193
Shinji Oki, Benjamin J.E. Raveney, Yoshimitsu Doi, and
Takashi Yamamura
Antiviral MicroRNA ............................................ 201
Ryota Ouda and Takashi Fujita
Synaptic Function Monitored Using Chemobiomolecular
Indicators .................................................... 207
Masamitsu Iino
Part III Chembiomolecular Medicinal Chemistry
Practical Catalytic Asymmetric Synthesis of a Promising Drug
Candidate ..................................................... 219
Masakatsu Shibasaki
Hunting the Targets of Natural Product-Inspired Compounds ..... 229
Slava Ziegler and Herbert Waldmann
Chemical Approaches for Understanding and Controlling
Infectious Diseases ........................................... 239
Hirokazu Arimoto
Nongenomic Mechanism-Mediated Renal Fibrosis-Decreasing
Activity of a Series of PPAR-γ Agonists ....................... 249
Hiroyuki Miyachi
Novel Carbohydrate-Based Inhibitors That Target Influenza
A Virus Sialidase ............................................. 261
Mark von Itzstein
Multidrug Efflux Pumps and Development of Therapeutic
Strategies to Control Infectious Diseases ..................... 269
Kunihiko Nishino
Enzymes as Chemotherapeutic Agents ............................ 281
Ronald T. Raines
Mechanism of Action of New Antiinfectious Agents from
Microorganisms ................................................ 293
Nobuhiro Koyama and Hiroshi Tomoda
Correction of RNA Splicing with Antisense Oligonucleotides
as a Therapeutic Strategy for a Neurodegenerative Disease ..... 301
Yimin Hua, Kentaro Sahashi, Frank Rigo, Gene Hung, C. Frank
Bennett, and Adrian R. Krainer
Modulation of Pre-mRNA Splicing Patterns with Synthetic
Chemicals and Their Clinical Applications ..................... 315
Masatoshi Hagiwara
Index ......................................................... 321
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