Contributors ................................................... ix
Preface ........................................................ xi
The Macro Scale I: Processing for Granulation
1 High Shear Granulation ....................................... 3
Gavin K. Reynolds, Phung K. Le and Amol M. Nilpawar
2 Fluidized Bed Spray Granulation ............................. 21
Lothar M&oum;rl, Stefan Heinrich and Mirko Peglow
3 Extrusion-Spheronisation ................................... 189
D. Ian Wilson and Sarah L. Rough
4 Drum Granulation Processes ................................. 219
Gavin M. Walker
5 Roll Pressing .............................................. 255
Pierre Guigon, Olivier Simon, Khashayar Saleh, Gururajan
Bindhumadhavan, Michael J. Adams and Jonathan P.K. Seville
6 Dry Granulation ............................................ 289
Kazuo Nishii and Masayuki Horio
7 Coating and Encapsulation Processes in Powder Technology ... 323
Khashayar Saleh and Pierre Guigon
8 Modelling of Pan-Coating Processes for Pharmaceutical
Dosage Forms ............................................... 377
Preetanshu Pandey, Yo'ngxin Song and Richard Turton
9 Granulation Equipment ...................................... 417
Michael Jacob
10 Online Monitoring .......................................... 477
Satoru Watano
11 Process Systems Engineering Applied to Granulation ......... 499
I.T. Cameron and F.Y. Wang
The Macro Scale II: Applications
12 Agglomeration of Enzymes, Micro-organisms and Flavours ..... 555
Gabrie M.H. Meesters
13 Agglomeration of Dehydrated Consumer Foods ................. 591
Stefan Palzer
14 Detergent Granulation ...................................... 673
Renee Boerefijn, Prasanna-Rao Dontula and Reinhard Kohlus
15 Granulation Process Control - Production of
Pharmaceutical Granules: The Classical Batch Concept and
the Problem of Scale-Up .................................... 705
Hans Leuenberger and Gabriele Betz
16 Tabletting ................................................. 735
Kendal Pitt and Csaba Sinka
17 Direct Peptization of Pharmaceutical Pellets in Fluid-Bed
Processes .................................................. 779
Peter Kleinebudde and Klaus Knop
The Meso Scale: Mechanistic Description
18 Shear-Induced Dispersion of Particle Agglomerates .......... 815
D.L. Feke
19 Scale-Up of High-Shear Binder-Agglomeration Processes ...... 853
Paul Mort
20 Granulation Rate Processes ................................. 897
K.P. Hapgood, S.M. Iveson, J.D. Litster and L.X. Liu
21 Breakage in Granulation .................................... 979
Agba D. Salman, Gavin K. Reynolds, Hong Sing Tan, Ian
Gabbott and Michael J. Hounslow
22 Fluidisation of Cohesive Particles ........................ 1041
Jonathan P.K. Seville
23 Multi-Level Computational Fluid Dynamics Models for the
Description of Particle Mixing and Granulation in
Fluidized Beds ............................................ 1071
M. van Sint Annaland, N.G. Deen and J.A.M. Kuipers
24 Population Balance Modelling of Granulation ............... 1109
Thomas Abberger
The Micro Scale: Granules and Smaller
25 Granule Structure ......................................... 1189
Daniel Barrera-Medrano, Agba D. Salman, Gavin
K. Reynolds and Michael J. Hounslow
26 Morphology and Strength Development in Solid and
Solidifying Interparticle Bridges in Granules of
Pharmaceutical Powders .................................... 1213
G.I. Tardos, L. Farber, D. Bika and J.N. Michaels
27 Liquid Bridges in Granules ................................ 1257
Stefaan J.R. Simons
28 Pendular Capillary Bridges ................................ 1317
Christopher D. Willett, Simon A. Johnson, Michael
J. Adams and Jonathan P.K. Seville
29 Sub-Granule Scale Modelling ............................... 1353
František Štěpánek
Subject Index ................................................ 1379
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