Foreword ...................................................... vii
Preface ........................................................ ix
Contributors ................................................... xi
Abbreviations ................................................ xiii
1 Catalytic Reduction of Amides Avoiding LНAIH4 or B2ih ........ 1
Deborah L. Dodds and David J. Cole-Hamilton
2 Hydrogenation of Esters ..................................... 37
Lionel A. Saudan
3 Synthesis of Chiral Amines Using Transaminases .............. 63
Nicholas J. Turner and Matthew D. Truppo
4 Development of a Sitagliptin Transaminase ................... 75
Jacob M. Janey
5 Direct Amide Formation Avoiding Poor Atom Economy
Reagents .................................................... 89
Benjamin M. Monks and Andrew Whiting
6 Industrial Applications of Boric Acid and Boronic
Acid-Catalyzed Direct Amidation Reactions .................. 111
Joanne E. Anderson, Jannine Cobb, Roman Davis, Peter
J. Dunn, Russ N. Fitzgerald, and Alan J. Pettman
7 OH Activation for Nucleophilic Substitution ................ 121
Jonathan M.J. Williams
8 Application of a Redox-Neutral Alcohol Amination in the
Kilogram-Scale Synthesis of a GlyTl Inhibitor .............. 139
Martin A. Berliner
9 Olefin Metathesis: From Academic Concepts to Commercial
Catalysts .................................................. 163
Justyna Czaban, Christian Torborg, and Karol Grela
10 Challenge and Opportunity in Scaling-up Metathesis
Reaction: Synthesis of Ciluprevir (BILN 2061) .............. 215
Nathan Yee, Xudong Wei, and Chris Senanayake
11 C-H Activation of Heteroaromatics .......................... 233
Koji Hirano and Masahiro Mima
12 The Discovery of a New Pd/Cu Catalytic System for C-H
Arylation and Its Applications in a Pharmaceutical
Process .................................................... 269
Jinkun Huang, Xiang Wang, and Johann Chan
13 Diarylprolinol Silyl Ethers: Development and Application
as Organocatalysts ......................................... 287
Hiroaki Gotoh and Yujiro Hayashi
14 Organocatalysis for Asymmetric Synthesis: From Lab to
Factory .................................................... 317
Feng Xu
15 Catalytic Variants of Phosphine Oxide-Mediated Organic
Transformations ............................................ 339
Stephen P. Marsden
16 Formation of C-C Bonds Via Catalytic Hydrogenation and
Transfer Hydrogenation ..................................... 363
Joseph Moran and Michael J. Krische
Index ......................................................... 409
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