Series Preface ................................................ vii
Preface ........................................................ ix
Acknowledgments ................................................ xi
Editors ...................................................... xiii
Contributors ................................................... xv
PART I In Vitro Studies
1 In Vitro Approaches to Site-Specific Imaging Agents .......... 3
Raymond E. Gibson
PART II Small Animal Studies
2 Small Animal Tumor Models for Use in Imaging ................ 19
Cheryl L. Marks
3 Animal Models in Cardiology ................................. 37
Wengen Chen, Henry Gewirtz, Mark Smith, and Vasken
Dilsizian
4 Imaging Diabetes in Small Animals: Models, Methods, and
Targets ..................................................... 71
Kooresh I. Shoghi
PART III Radiopharmacology and Radiopharmacy
5 Targeted Radiopharmaceuticals: Advances in
Radiopharmacology and Radiopharmacy ......................... 91
Cathy S. Cutler and Sally W. Schwarz
PART IV Case Studies on Developing Targeted Nonnuclear
Probes
6 Targeted Optical Molecular Imaging with Cytate: From
Bench toward Bedside ....................................... 113
Yang Liu and Samuel Achilefu
7 Molecular Imaging of P-Selectin with Contrast Ultrasound
for the Detection of Recent Tissue Ischemia ................ 127
Brian Davidson and Jonathan R. Lindner
8 Evolution of Magnetic Nanoparticles: From Imaging to
Therapy .................................................... 139
Yali Li and Jason R. McCarthy
PART V Case Studies on Developing Targeted Radiotracers
9 Targeting Prostate Cancer with Small Molecule Inhibitors
of Prostate-Specific Membrane Antigen ...................... 161
John W. Babich, John L. Joyal, and R. Edward Coleman
10 Imaging Infection Based on Expression of Thymidine Kinase .. 175
Chetan Bettegowda, Youngjoo Byun, Catherine A. Foss,
George Sgouros, Richard F Ambinder, and Martin G. Pomper
11 Design Criteria for Targeted Molecules - Muscarinic
Cholinergic Systems Biology ................................ 201
William C. Eckelman
12 Radioligands for the Vesicular Monoamine Transporter
Type 2 ..................................................... 217
Michael R. Kilbourn
13 Radiopharmaceuticals for Imaging Proliferation ............. 231
Kenneth A. Krohn, John R. Grierson, MarkMuzi, and Jeffrey
L. Schwartz
14 [99mTc]TRODAT: Dopamine Transporter Imaging Agent for
SPECT ...................................................... 253
Hank F. Kung and Karl Ploessl
15 Development of Radiotracers and Fluorescent Probes for
Imaging Sigma-2 Receptors In Vitro and In Vivo ............. 263
Robert H. Mach and Kenneth T. Wheeler
16 Steroid Hormone Ligands for the Estrogen Receptor .......... 279
David A. Mankoff, Jeanne M. Link, and Hannah M. Linden
17 Targeting Norepinephrine Transporters in Cardiac
Sympathetic Nerve Terminals ................................ 305
David M. Raffel
18 PET Quantification of Myocardial Metabolism: Challenges
and Opportunities .......................................... 321
Arun K. Thukkani and Robert J. Gropler
19 Development of Receptor-Avid Peptide Radiotracers for
Targeting Human Cancers .................................... 337
Wynn A. Volkert, Thomas P. Quinn, C. Jeffrey Smith, and
Timothy J. Hoffman
Index ......................................................... 359
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