1 Modeling Formalisms in Systems Biology of Apoptosis .......... 1
Stefan Kallenberger and Stefan Legewie
2 Systems Biology of Death Receptor-Induced Apoptosis ......... 33
Kolja Schleich and Inna N. Lavrik
3 Systematic Complexity Reduction of Signaling Models and
Application to a CD95 Signaling Model for Apoptosis ......... 57
Dennis Rickert, Nicolai Flicker, Inna N. Lavrik, and
Fabian J. Theis
4 Systems Biology of the Mitochondrial Apoptosis Pathway ...... 85
lochen H.M. Prehn, Heinrich J. Huber, and Carla O'Connor
5 Systems Biology of Cell Death in Hepatocytes ............... 101
Rebekka Schlatter, Kathrin Schmich, Christoph Borner,
Michael Ederer, and Irmgard Merfort
6 Understanding Different Types of Cell Death Using Systems
Biology .................................................... 125
Laurence Calzone, Andrei Zinovyev, and Boris Zhivotovsky
7 Modeling Single Cells in Systems Biology ................... 145
Nicolai Flicker and Inna N. Lavrik
8 Cytokine-Cytokine Cross Talk and Cell-Death Decisions ...... 163
Christopher D. Deppmann and Kevin A. Janes
9 Genetic and Genomic Dissection of Apoptosis Signaling ...... 181
Christina Falschlehner and Michael Boutros
Index ......................................................... 199
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