Preface ......................................................... v
Contributors ................................................. xiii
1 The Major Histocompatibility Complex: A Paradigm for
Studies of the Human Genome .................................. 1
Richard J.N. Allcock
2 HLA Typing by SSO and SSP Methods ............................ 9
Heather Dunckley
3 Methods for Diagnostic HLA Typing in Disease Association
and Drug Hypersensitivity ................................... 27
Michael D. Varney, Alison S.L. Castley, Katri Haimila,
and Pdivi Saavalainen
4 HLA Typing Using Bead-Based Methods ......................... 47
Daniel Trajanoski and Samantha J. Fidler
5 HLA Typing by Direct DNA Sequencing ......................... 67
Linda K. Smith
6 Data Analysis of HLA Sequencing Using Assign-SBT v3.6+
from Conexio Carta Wirtz and David Sayer .................... 87
7 Simple Methods for the Detection of HLA-G Variants in
Coding and Non-coding Regions .............................. 123
Holger Nückel, Erick C. Castelli, Philippe Moreau,
Crista Ochsenfarth, Peter A. Horn, and Vera Rebmann
8 Molecular Typing of HLA-E .................................. 143
Nina Lauterbach, Christina E.M. Voorter, and Marcel
G.J. Tilanus
9 Molecular Analysis of Complement Component C4 Gene Copy
Number ..................................................... 159
Alison S.L. Castley and O. Patricia Martinez
10 Genotyping of Single Nucleotide Polymorphisms by 5'
Nuclease Allelic Discrimination ............................ 173
Mari Malkki and Effie W. Petersdorf
11 High Resolution MICA Genotyping by Sequence-Based Typing
(SBT) ...................................................... 183
Yizhou Zou and Peter Stastny
12 Standard Methods for the Management of Immunogenetic Data .. 197
Pierre-Antoine Gourraud, Jill A. Hollenbach, Thomas
Barnetche, Richard M. Single, and Steven J. Mack
13 Analytical Methods for Immunogenetic Population Data ....... 215
Steven J. Mack, Pierre-Antoine Gourraud, Richard
M. Single, Glenys Thomson, and Jill A. Hollenbach
14 Analytical Methods for Disease Association Studies with
Immunogenetic Data ......................................... 245
Jill A. Hollenbach, Steven J. Mack, Glenys Thomson, and
Pierre-Antoine Gourraud
15 Impact of HLA Matching and HLA Antibodies in Organ
Transplantation: A Collaborative Transplant Study View ..... 267
Caner Süsal and Gerhard Opelz
16 Screening for Antibodies Against MICA by Luminex Flow
Cytometry .................................................. 279
Yizhou Zou and Peter Stastny
17 HLA Antibody Detection and Characterization by Solid
Phase Immunoassays: Methods and Pitfalls ................... 289
Andrea A. Zachary, Renato M. Vega, Donna P. Lucas, and
Mary S. Leffell
18 Detection and Characterisation of Alloreactive T Cells ..... 309
Mandvi Bharadwaj, Nicole A. Mifsud, and James McCluskey
19 Detection of Allo-HLA Cross-Reactivity by Virus-specific
Memory T-Cell Clones Using Single HLA-Transfected K562
Cells ...................................................... 339
Lloyd J. D'Orsqgna, Ellen M.W. van der Meer-Prins,
Yvonne M. Zoet, Dave L. Roelen, Llias I.N. Doxiadis, and
Frans H.J. Claas
20 Separation and Cryopreservation of Lymphocytes from
Spleen and Lymph Node ...................................... 351
Gabriella Tassone and Samantha J. Fidler
21 Crossmatching by Complement-Dependent Lymphocytotoxicity ... 359
Samantha J. Fidler
22 The Lymphocyte Crossmatch by Flow Cytometry for Kidney
Transplantation ............................................ 379
Jonathan Downing
23 Overview of the Killer Cell Immunoglobulin-Like Receptor
System ..................................................... 391
Raja Rajalingam
24 KIR Typing by Non-Sequencing Methods: Polymerase-Chain
Reaction with Sequence-Specific Primers .................... 415
David Ordóñez, Manuela Moraru, Natalia Gómez-Lozano,
Elisa Cisneros, and Carlos Vilches
25 Killer Cell Immunoglobulin-Like Receptors (KIR) Typing
by DNA Sequencing .......................................... 431
Lihua Hou, Minghua Chen, Noriko Steiner, Kanthi
Kariyawasam, Jennifer Ng, and Carolyn K. Hurley
26 An Overview of Methods Required to Evaluate Donor NK Cell
Alloreactivity for Haploidentical Haemopoietic Stem Cell
Transplantation ............................................ 469
Andrea Velardi
27 The Detection of NK Cell Alloreactivity by Flow
Cytometric CD107a Assay .................................... 477
Dianne De Santis, Bree Foley, Campbell S. Witt, and
Frank T. Christiansen
28 Clinical Production and Therapeutic Applications of
AUoreactive Natural Killer Cells ........................... 491
David H. McKenna, Diane M. Kadidlo, Sarah Cooley, and
Jeffrey S. Miller
29 Minor Histocompatibility Antigen Typing by DNA Sequencing
for Clinical Practice in Hematopoietic Stem-Cell
Transplantation ............................................ 509
Eric Spierings and Els Goulmy
30 Donor Registries and Search Strategies ..................... 531
Carolyn K. Hurley, Machteld Oudshoorn, and Michelle
Setterholm
31 Cytokine Gene Polymorphisms: Methods of Detection and
Biological Significance .................................... 549
Gurvinder Kaur and Narinder Mehra
32 IMGT® Tools for the Nucleotide Analysis of Immunoglobulin
(IG) and T Cell Receptor (TR) V-(D)-J Repertoires,
Polymorphisms, and IG Mutations: IMGT/V-QUEST and
IMGT/HighV-QUEST for NGS ................................... 569
Eltaf Alamyar, Patrice Duroux, Marie-Paule Lefranc, and
Véronique Giudicelli
33 IMGT/DomainGapAlign: The IMGT® Tool for the Analysis of
IG, TR, MH, IgSF, and MhSF Domain Amino Acid Polymorphism .. 605
François Ehrenmann and Marie-Paule Lefranc
34 Human Gm, Km, and Am Allotypes and Their Molecular
Characterization: A Remarkable Demonstration of
Polymorphism ............................................... 635
Marie-Paule Lefranc and Gerard Lefranc
Index ......................................................... 681
|
