Preface ........................................................ ix
Editor ......................................................... xi
Contributors ................................................. xiii
Chapter 1 Strategies and Methods for a Sustainable Search
for Bioactive Compounds .............................. 1
Lars Bohlin, Cecilia Alsmark, Ulf Göransson, Mattias
Klum, Christina Wedén, and Anders Backlund
Chapter 2 Discovery of Potential Anticancer Agents from
Aquatic Cyanobacteria, Filamentous Fungi, and
Tropical Plants ..................................... 37
Jimmy Orjala, Nicholas H. Oberlies, Cedric
J. Pearce, Steven M. Swanson, and A. Douglas
Kinghorn
Chapter 3 Metabolic Engineering of Natural Product
Biosynthesis ........................................ 65
Xinkai Xie, Kangjian Qiao, and Yi Tang
Chapter 4 Computational Approaches for the Discovery of
Natural Lead Structures ............................. 97
Judith M. Rollinger and Gerhard Wolber
Chapter 5 Recent Advances in the Application of Electronic
Circular Dichroism for Studies of Bioactive
Natural Products ................................... 133
Nina Berova, George Ellestad, Koji Nakanishi, and
Nobuyuki Harada
Chapter 6 Natural Products as Treatments for and Leads to
Active Compounds in Viral Diseases ................. 167
David J. Newman and Gordon M. Cragg
Chapter 7 Natural Products as Inhibitors of Hypoxia-
Inducible Factor-1 ................................. 187
Dale G. Nagle and Yu-Dong Zhou
Chapter 8 Antitumor or Wound Healing Actions of Natural
Products through Inhibiting or Enhancing
Angiogenesis ....................................... 265
Yoshiyuki Kimura
Chapter 9 From Natural Polyphenols to Synthetic Antitumor
Agents ............................................. 299
Carmela Spatafora and Corrado Tringali
Chapter 10 Resveratrol against Major Pathologies: From Diet
Prevention to Possible Alternative Chemotherapies
with New Structural Analogues ...................... 339
Norbert Latruffe, Dominique Delmas, Gérard
Lizard, Corrado Tringali, Carmela Spatafora,
Dominique Vervandier-Fasseur, and Philippe
Meunier
Chapter 11 Drug Discovery from Natural Substances: A Case
Study—Camptothecins ................................ 379
Gabriele Fontana and Lucio Merlini
Chapter 12 Plant Compounds and Derivatives as Inhibitors of
Cancer Cell Multidrug Resistance ................... 409
Virginia Lanzotti, Orazio Taglialatela-Scafati,
Ernesto Fattorusso, and Attilio Di Pietro
Chapter 13 Recent Advances in the Search of Novel Calmodulin
Inhibitors from Selected Mexican Plants and Fungi .. 451
Rachel Mata, Mario Figueroa, Isabel Rivero-Cruz,
and Martín González-Andrade
Chapter 14 Neuroprotective Effects of Natural Products from
Traditional Chinese Herbs .......................... 497
Hai Yan Zhang and Xi Can Tang
Chapter 15 Drugs for the Neglected Disease Malaria Based
on Natural Products ................................ 525
S. Brøgger Christensen and lb Christian Bygbjerg
Chapter 16 Endophytic Microorganisms as a Source of
Bioactive Compounds ................................ 551
Yoshihito Shiono and Ken-ichi Kimura
Chapter 17 Biologically Active Natural Products from
Australian Marine Organisms ........................ 579
Robert J. Capon
Natural Source Index .......................................... 603
Subject Index ................................................. 607
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