Prefatory
Ehristdan Raetz: Scientist and Friend Extraordinaire
Villiam Dowhan, Hiroshi Nikaido, JoAnne Stubbe, John
W. Kozarich, William T. Wickner, David W. Russell,
Teresa A. Garrett, Kathryn Broїek, and Paul Modrich ......... 1
Recent Advances in Biochemistry
Mechanisms for Initiating Cellular DNA Replication
Alessandro Costa, Iris V. Hood, and James M. Berger ......... 25
Chromatin Response to DNA Breaks: Leaving a Mark on Genome
Integrity
Godelieve Smeenk and Haico van Attikum ...................... 55
Readout of Epigenetic Modifications
Dinshaw J. Patel and Zhanxin Wang ........................... 81
Flap Endonuclease 1
Lata Balakrishnan and Robert A. Bambara .................... 119
New Mechanistic and Functional Insights into DNA
Topoisomerases
Stefanie Hartman Chen, Nei-Li Chan, and Tao-shih Hsieh ..... 139
Arrest Peptides: Cw-Acting Modulators of Translation
Koreaki Ito and Shinobu Chiba .............................. 171
Structural Basis of the Translational Elongation Cycle
Rebecca M. Voorhees and V. Ramakrishnan .................... 203
CRISPR-Mediated Adaptive Immune Systems in Bacteria and
Archaea
Rotem Sorek, С. Martin Lawrence, and Blake Wiedenheft ...... 237
Correlating Structure and Energetics in Protein-Ligand
Interactions: Paradigms and Paradoxes
Stephen F. Martin and John H. Clements ..................... 267
Extracellular Chaperones and Proteostasis
Amy R. Wyatt, Justin J. Yerbury, Heath Ecroyd, and Mark
R. Wilson .................................................. 295
Molecular Chaperone Functions in Protein Folding and
Proteostasis
Yujin E. Kim, Mark S. Hipp, Andreas Bracher, Manajit
Hayer-Hartl, and F. Ulrich Hartl ........................... 323
Sumoylation: A Regulatory Protein Modification in Health and
Disease
Annette Flotho and Frauke Melchior ......................... 357
Ubiquitin Ligases and Cell Cycle Control
Leonardo K. Teixeira and Steven I. Reed .................... 387
Molecular Architecture and Assembly of the Eukaryotic
Proteasome
Robert J. Tomko Jr. and Mark Hochstrasser .................. 415
Design of Protein Catalysts
Donald Hilvert ............................................. 447
Hydrogen Tunneling Links Protein Dynamics to Enzyme
Catalysis
Judith P. Klinman andAmnon Kohen ........................... 471
Methylerythritol Phosphate Pathway of Isoprenoid
Biosynthesis
Lishan Zhao, Wei-chen Chang, Youli Xiao, Hung-wen Liu,
and Pinghua Liu ............................................ 497
Posttranslational Biosynthesis of the Protein-Derived
Cofactor Tryptophan Tryptophylquinone
Victor L. Davidson and Carrie M. Wilmot .................... 531
Mitochondrial Complex I
Judy Hirst ................................................. 551
Photosystem II: The Reaction Center of Oxygenic
Photosynthesis
David J. Vinyard, Gennady M. Ananyev, and G. Charles
Dismukes ................................................... 577
The Voltage-Gated Calcium Channel Functions as the Molecular
Switch of Synaptic Transmission
Daphne Atlas ............................................... 607
Sphingosine-1-Phosphate and Its Receptors: Structure,
Signaling, and Influence
Hugh Rosen, Raymond C. Stevens, Michael Hanson, Edward
Roberts, Michael B.A. Oldstone ............................. 637
Membrane Fission Reactions of the Mammalian ESCRT Pathway
John McCullough, Leremy A. Coif, and Wesley I. Sundquist ... 663
Signal Recognition Particle: An Essential Protein-Targeting
Machine
David Akopian, Kuang Shen, Xin Zhang, and Shu-ou Shan ...... 693
Peroxisome Formation and Maintenance Are Dependent on the
Endoplasmic Reticulum
Henk F. Tabak, Ineke Braakman, and Adabella van der Zand ... 723
Systemic Amyloidoses
Luis M. Blancas-Mejia and Marina Ramirez-Alvarado .......... 745
Nanobodies: Natural Single-Domain Antibodies
Serge Muyldermans .......................................... 775
Indexes
Cumulative Index of Contributing Authors, Volumes 78-82 ....... 799
Cumulative Index of Article Titles, Volumes 78-82 ............. 803
Errata
An online log of corrections to Annual Review of
Biochemistry articles may be found at
http://biochem.annualreviews.org/errata.shtml
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