Preface ......................................................... v
Contributors ................................................... ix
Section I Imaging Biochemical Pathways and Molecular Events
1 Bioluminescence Resonance Energy Transfer (BRET) Imaging
in Plant Seedlings and Mammalian Cells ....................... 3
Qiguang Xie*, Mohammed Soutto*, Xiaodong Xu*, Yunfei Zhang,
and Carl Hirschie Johnson (* equal contributors)
2 Luciferase Protein Complementation Assays for
Bioluminescence Imaging of Cells and Mice ................... 29
Gary D. Luker and Kathryn E. Luker
3 Hybrid Raman-Fluorescence Microscopy on Single Cells Using
Quantum Dots ................................................ 45
Henk-Jan van Manen and Cees Otto
4 Labeling of Mesenchymal Stem Cells with Bioconjugated
Quantum Dots ................................................ 61
Bhranti S. Shah and Jeremy J. Mao
5 Quantification of miRNA Abundance in Single Cells Using
Locked Nucleic Acid-FISH and Enzyme-Labeled Fluorescence .... 77
Jing Lu and Andrew Tsourkas
Section II Imaging in Pre-clinical Settings
6 Imaging Fate of Stem Cells at a Cellular Resolution in
the Brains of Mice .......................................... 91
Khalid Shah
7 Magnetic Resonance Imaging of Brain Inflammation Using
Microparticles of Iron Oxide ............................... 103
Martina A. McAteer, Constantin von Zur Muhlen, Daniel С.
Anthony, Nicola R. Sibson, and Robin P. Choudhury
8 Optical Characterization of Arterial Apoptosis ............. 117
Maarten F. Carsten and Abdelkader Bennaghmouch
9 Intravital Fluorescence Microscopic Molecular Imaging of
Atherosclerosis ............................................ 131
Farouc A. Jaffer
10 MR Imaging of Transplanted Stem Cells in Myocardial
Infarction ................................................. 141
Dara L. Kraitchman, Dorota A. Kedziorek, and Jeff
W.M. Bulte
11 In Vivo Imaging of the Dynamics of Different Variants of
EGFR in Glioblastomas ...................................... 153
Khalid Shah
12 Fluorescence Lifetime-Based Optical Molecular Imaging ...... 165
Anand T.N. Kumar
Section III Imaging in Clinical Settings
13 PET Imaging of αvβ3 Expression in Cancer Patients .......... 183
Ambros J. Beer and Markus Schwaiger
14 Quantitative Approaches to Amyloid Imaging ................. 201
Victor L. Villemagne, Graeme O'Keefe, Rachel S. Mulligan,
and Christopher C. Rowe
15 Molecular Imaging of Myocardial Remodeling After
Infarction ................................................. 227
Johan W.H. Verjans, Susanne W.M. van de Borne, Leonard
Hofstra, and Jagat Narula
16 Dual-Radionuclide Brain SPECT for the Differential
Diagnosis of Parkinsonism .................................. 237
Georges El Fakhri and Jinsong Ouyang
Index ......................................................... 247
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