Contributors ................................................... xi
List of Abbreviations .......................................... xv
1 Thymocyte Development ........................................ 1
William Jenkinson, Eric Jenkinson, and Graham Anderson
2 A Review of Mathematical Models for T Cell Receptor
Triggering and Antigen Discrimination ....................... 25
Daniel Coombs, Omer Dushek, and P. Anton van der Merwe
3 Dynamic Tuning of T Cell Receptor Specificity by
Co-Receptors and Costimulation .............................. 47
Hugo A. van den Berg and Andrew K. Sewell
4 T Cell Activation and Function: Role of Signal Strength ..... 75
Asma Ahmed and Dipankar Nandi
5 The Cyton Model for Lymphocyte Proliferation and
Differentiation ............................................ 107
Cameron Wellard, John F. Markham, Edwin D. Hawkins, and
Phillip D. Hodgkin
6 Modelling Intravital Two-Photon Data of Lymphocyte
Migration and Interaction .................................. 121
Marc Thilo Figge and Michael Meyer-Hermann
7 Modelling Lymphocyte Dynamics In Vivo ...................... 141
Becca Asquith and José A.M. Borghans
8 Continuous-Time Birth and Death Processes: Diversity
Maintenance of Naive T Cells in the Periphery .............. 171
Carmen Molina-París, Emily Stirk, Katie Quinn, and Grant
Lythe
9 Multivariate Competition Processes: A Model for Two
Competing T Cell Clonotypes ................................ 187
Carmen Molina-Paris, Grant Lythe, and Emily Stirk
10 Stochastic Modelling of T Cell Homeostasis for Two
Competing Clonotypes Via the Master Equation ............... 207
Shev MacNamara and Kevin Burrage
11 Dendritic Cell Migration in the Intestinal Tract ........... 227
Rowann Bowcutt and Sheena Cruickshank
12 Reassessing Germinal Centre Reaction Concepts .............. 241
Jose Faro and Michal Or-Guil
13 В Cell Strategies of Ag Recognition in a Stratified
Immune System .............................................. 259
Belen de Andrés, Ana R. Sánchez-Archidona, Isabel
Cortegano, Natalia Serrano, Sharmili Jagtap,
María-Luisa Gaspar, and Miguel-Angel Rodríguez Marcos
14 Dynamics of Peripheral Regulatory and Effector T Cells
Competing for Antigen Presenting Cells ..................... 275
Nuno Sepúlveda and Jorge Carneiro
15 Mathematical Models of the Role of IL-2 in the
Interactions Between Helper and Regulatory CD4+ T Cells .... 305
Kalet León and Karina García-Martínez
16 A Physicist's Approach to Immunology ....................... 339
Mario Castro
17 Timescales of the Adaptive Immune Response ................. 351
Mark Day and Grant Lythe
18 Using Mathematical Models to Explore the Role
of Cytotoxic T Lymphocytes in HIV Infection ............... 363
Helen Fryer and Angela McLean
19 Viral Immunity and Persistence ............................. 383
Stephen Hickling and Rodney Phillips
Index ......................................................... 405
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