Foreword by Richard Danzig ..................................... ix
1 Introduction ................................................. 1
Jonathan B. Tucker
I Assessing and Managing Dual-Use Risks ....................... 17
2 Review of the Literature on Dual Use ........................ 19
Jonathan B. Tucker
3 Current Dual-Use Governance Measures ........................ 45
Lori P. Knowles
4 The Decision Framework ...................................... 67
Jonathan B. Tucker
II Contemporary Case Studies ................................... 85
A Technologies for the Acquisition of Novel Biological or
Molecular Diversity ......................................... 87
5 Combinatorial Chemistry and High-Throughput Screening ....... 89
Jonathan B. Tucker
6 DNA Shuffling and Directed Evolution ....................... 101
Gerald L. Epstein
В Technologies for Directed Design ........................... 117
7 Protein Engineering ........................................ 119
Catherine Jefferson
8 Synthesis of Viral Genomes ................................. 133
Filippa Lentzos and Pamela Silver
9 Synthetic Biology with Standard Parts ...................... 147
Alexander Kelle
С Technologies for the Manipulation of Biological Systems .... 161
10 Development of Psychoactive Drugs .......................... 163
Malcolm R. Dando
11 Synthesis of Peptide Bioregulators ......................... 173
Ralf Trapp
12 Immunological Modulation ................................... 187
Nancy Connell
13 Personal Genomics .......................................... 199
Nishal Mohan
14 RNA Interference ........................................... 209
Matthew Metz
15 Transcranial Magnetic Stimulation .......................... 223
Jonathan D. Moreno
D Technologies for Production, Packaging, or Delivery ........ 233
16 Chemical Micro Process Devices ............................. 235
Amy E. Smithson
17 Gene Therapy ............................................... 249
Gail Javitt and Anya Prince
18 Aerosol Vaccines ........................................... 261
Raymond A. Zilinskas and Hussein Alramini
III Historical Case Studies ................................... 271
19 Development of the V-Series Nerve Agents ................... 273
Caitríona McLeish and Brian Balmer
20 The Use and Misuse of LSD by the U.S. Army and the CIA ..... 289
Mark Wheelis
IV Findings and Conclusions .................................. 303
21 Governance of Emerging Dual-Use Technologies ............... 305
Kirk C. Bansak and Jonathan B. Tucker
Select Bibliography ........................................... 341
Contributors .................................................. 345
Index ......................................................... 347
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