Preface ....................................................... vii
Overview of the Matrisome - An Inventory of Extracellular
Matrix Constituents and Functions ............................... 1
Richard O. Hynes and Alexandra Naba
Basement Membranes: Cell Scaffoldings and Signaling Platforms .. 17
Peter D. Yurchenco
The Collagen Family ............................................ 45
Silvie Ricard-Blum
Heparan Sulfate Proteoglycans .................................. 65
Stephane Sarrazin, William С. Lamanna, and Jeffrey D. Esko
The Thrombospondins ............................................ 99
Josephine C. Adams and Jack Lawler
Tenascins and the Importance of Adhesion Modulation ........... 129
Ruth Chiquet-Ehrismann and Richard R. Tucker
Fibronectins, Their Fibrillogenesis, and In Vivo Functions .... 149
Jean E. Schwarzbauer and Douglas W. DeSimone
Integrin Structure, Activation, and Interactions .............. 169
Iain D. Campbell and Martin J. Humphries
Cross Talk among TGF-β Signaling Pathways, Integrins, and
the Extracellular Matrix ...................................... 183
John S. Munger and Dean Sheppard
Molecular Architecture and Function of Matrix Adhesions ....... 201
Benjamin Geiger and Kenneth M. Yamada
Genetic Analyses of Integrin Signaling ........................ 223
Sara A. Wickström, Korana Radovanac, and Reinhard Fässler
Integrins and Extracellular Matrix in Mechanotransduction ..... 245
Martin Alexander Schwartz
Integrins in Cell Migration ................................... 259
Anna Huttenlocher and Alan Rick Horwitz
Extracellular Matrix Degradation and Remodeling in
Development and Disease ....................................... 275
Pengfei Lu, Ken Takai, Valerie M. Weaver, and Zena Werb
Extracellular Matrix in Development: Insights from
Mechanisms Conserved between Invertebrates and Vertebrates .... 299
Nicholas H. Brown
Angiogenesis .................................................. 313
Donald R. Senger and George E. Davis
Extracellular Matrix: Functions in the Nervous System ......... 333
Claudia S. Barros, Santos J. Franco, and Ulrich Müller
Cell-Extracellular Matrix Interactions in Normal and
Diseased Skin ................................................. 357
Fiona M. Watt and Hironobu Fujiwara
Extracellular Matrix Proteins in Hemostasis and Thrombosis .... 371
Wolfgang Bergmeier and Richard O. Hynes
Index ......................................................... 389
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