Contributors ................................................... ix
I GENERAL PRINCIPLES OF CELL DEATH
1 Human Caspases - Apoptosis and Inflammation Signaling
Proteases .................................................... 1
Guy S. Salvesen
2 Inhibitor of Apoptosis Proteins ............................. 11
Jason B. Garrison, Andreas Krieg, Kate Welsh, Yunfei Wen,
and John C. Reed
3 Death Domain-Containing Receptors - Decisions between
Suicide and Fire ............................................ 23
Henning Walczak and Chahrazade Kantari
4 Mitochondria and Cell Death ................................. 37
Gavin P. McStay and Douglas R. Green
5 The Control of Mitochondrial Apoptosis by the BCL-2 Family .. 44
Anthony Letai
6 Endoplasmic Reticulum Stress Response in Cell Death and
Cell Survival ............................................... 51
Michael Boyce, Marta M. Lipinski, Bénédicte F. Py, and
Junying Yuan
7 Autophagy - The Liaison between the Lysosomal System and
Cell Death .................................................. 63
Hiroshi Koga and Ana Maria Cuervo
8 Cell Death in Response to Genotoxic Stress and DNA Damage ... 74
Pablo Lopez-Bergami and Ze'ev Ronai
9 Ceramide and Lipid Mediators in Apoptosis ................... 88
Thomas D. Mullen, Russell W. Jenkins, Lina M. Obeid, and
Yusuf A. Hannun
10 Cytotoxic Granules House Potent Proapoptotic Toxins
Critical for Antiviral Responses and Immune Homeostasis .... 106
Katherine Baran, Ilia Voskoboinik, Nigel J. Waterhouse,
Vivien R. Sutton, and Joseph A. Trapani
II CELL DEATH IN TISSUES AND ORGANS
11 Cell Death in Nervous System Development and Neurological
Disease .................................................... 123
JuyingLi and Junying Yuan
12 Role of Programmed Cell Death in Neurodegenerative
Disease .................................................... 135
Dale E. Bredesen
13 Implications of Nitrosative Stress-Induced Protein
Misfolding in Neurodegeneration ............................ 145
Tomohiro Nakamura and Stuart A. Lipton
14 Mitochondrial Mechanisms of Neural Cell Death in Cerebral
Ischemia ................................................... 153
Lucian Soane, Brian M. Polster, and Gary Fiskum
15 Cell Death in Spinal Cord Injury - An Evolving Taxonomy
with Therapeutic Promise ................................... 154
Rajiv R. Ratan and Moses V. Chao
16 Apoptosis and Homeostasis in the Eye ....................... 176
Jerry Y. Niederkorn
17 Cell Death in the Inner Ear ................................ 182
Lisa L. Cunningham and Justin Tan
18 Cell Death in the Olfactory System ......................... 194
Pawel Kermer
19 Contribution of Apoptosis to Physiologic Remodeling of
the Endocrine Pancreas and Pathophysiology of Diabetes ..... 201
Nika N. Danial
20 Apoptosis in the Physiology and Diseases of the
Respiratory Tract .......................................... 221
Christian Taube and Martin Schьler
21 Regulation of Cell Death in the Gastrointestinal Tract ..... 231
Maria Eugenia Guicciardi and Gregory J. Gores
22 Apoptosis in the Kidney .................................... 240
Juan Antonio Moreno, Adrian Mario Ramos, and Alberto
Ortiz
23 Physiologic and Pathological Cell Death in the Mammary
Gland ...................................................... 250
Armelle Melet and Roya Khosravi-Far
24 Therapeutic Targeting Apoptosis in Female Reproductive
Biology .................................................... 273
Kaisa Selesniemi and Jonathan L. Tilly
25 Apoptotic Signaling in Male Germ Cells ..................... 283
Amiya P. Sinha Hikim, Yue Jia, Yan-He Lue, Christina
Wang, and Ronald S. Swerdloff
26 Cell Death in the Cardiovascular System .................... 295
Vladimir Kaplinskiy, Martin R. Bennett, and Richard
N. Kitsis
27 Cell Death Regulation in Muscle ............................ 313
Ayesha Saleem, Lawrence Kazak, Michael O'Leary, and David
A. Hood
28 Cell Death in the Skin ..................................... 323
Saskia Lippens, Esther Hoste, Peter Vandenabeele, and Wim
Declercq
29 Apoptosis and Cell Survival in the Immune System ........... 333
Delphine Mérino and Philippe Bouillet
30 Cell Death Regulation in the Hematopoietic System .......... 350
Paul A. Ney
31 Apoptotic Cell Death in Sepsis ............................. 363
Pavan Brahmamdam, Jared T. Muenzer, Richard S. Hotchkiss,
and Jonathan E. McDunn
32 Host-Pathogen Interactions ................................. 372
Maya Saleh
III CELL DEATH IN NONMAMMALIAN ORGANISMS
33 Programmed Cell Death in the Yeast Saccharomyces
cerevisiae ................................................. 389
Valter D. Longo and Cristina Mazzoni
34 Caenorhabditis elegans and Apoptosis ....................... 397
Brian L. Harry and Ding Xue
35 Apoptotic Cell Death in Drosophila ......................... 407
Kathleen Galindo and John M. Abrams
36 Analysis of Cell Death in Zebrafish ........................ 412
Ujwal J. Pyati and A. Thomas Look
Color plates follow ........................................... 226
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