1 Principles and Roots of Neutron Capture Therapy .............. 1
Wolfgang A.G. Sauerwein
Part I Neutron Sources
2 Fission Reactor-Based Irradiation Facilities for Neutron
Capture Therapy ............................................. 19
Otto K. Harling and Kent J. Riley
3 Accelerator-Based BNCT ...................................... 41
Andres J. Kreiner
4 Compact Neutron Generator for BNCT .......................... 55
Ka-Ngo Leung
5 Californium-252 as a Neutron Source for BNCT ................ 69
Albert Miller
Part II Boron
6 Boron Chemistry ............................................. 77
Luigi Panza and Davide Prosperi
7 Boron Compounds: New Candidates for Boron Carriers in BNCT .. 99
Hiroyuki Nakamura and Mitsunori Kirihata
8 Drugs for BNCT: BSH and BPA ................................ 117
Wolfgang A.G. Sauerwein, Pierre M. Bet, and Andrea Wittig
Part III Analysis and Imaging
9 Boron Analysis and Boron Imaging in BNCT ................... 163
Andrea Wittig and Wolfgang A.G. Sauerwein
10 Proteomic Investigations for Boron Neutron Capture
Therapy .................................................... 189
Pier Luigi Mauri and Fabrizio Basilico
11 Analysis and Imaging: PET .................................. 201
Tadashi Nariai and Kiichi Ishiwata
12 Boron Imaging: Localized Quantitative Detection and
Imaging of Boron by Magnetic Resonance ..................... 213
Peter Bendel
Part IV Physics
13 Physical Dosimetry and Spectral Characterization of
Neutron Sources for Neutron Capture Therapy ................ 227
David W. Nigg
14 The Clinical Commissioning of Beams for Neutron Capture
Therapy .................................................... 259
Per Munck af Rosenschöld
15 Prescribing, Recording and Reporting of BNCT ............... 277
Jürgen Rassow and Wolfgang A.G. Sauerwein
16 Treatment Planning ......................................... 287
W.S. Kiger III and Hiroaki Kumada
Part V Biology
17 Boron Neutron Capture Therapy: Application of
Radiobiological Principles ................................. 329
John W. Hopewell, Gerard M. Morris, Amanda E. Schwint,
and Jeffrey A. Coderre
18 Tolerance of Healthy Tissues and Ideal Radiation Dose on
BNCT ....................................................... 359
Yoshinobu Nakagawa and Teruyoshi Kageji
Part VI Clinical Applications
19 Clinical Trials in BNCT: A Challenging Task ................ 369
Andrea Wittig and Wolfgang A.G. Sauerwein
20 External Beam BNCT for Glioblastoma Multiforme ............. 377
Tetsuya Yamamoto and Akira Matsumura
21 Clinical Results of Sodium Borocaptate (BSH)-Based
Intraoperative Boron Neutron Capture Therapy (IO-BNCT) ..... 389
Teruyoshi Kageji, Yoshinobu Nakagawa, and Hiroaki Kumada
22 Boron Neutron Capture Therapy for Malignant Meningiomas .... 399
Shinji Kawabata and Shin-Ichi Miyatake
23 Feasibility for Intramedullary Spinal Glioma ............... 407
Kei Nakai and Akira Matsumura
24 BNCT for Advanced or Recurrent Head and Neck Cancer ........ 417
Terahito Aihara and Norimasa Morita
25 Studies on the Possible Application of BNCT to Thyroid
Cancer ..................................................... 425
Mario A. Pisarev, Maria A. Dagrosa, and Guillermo
J. Juvenal
26 Malignant Melanoma ......................................... 433
Junichi Hiratsuka and Hiroshi Fukuda
27 Application of Neutron Capture Therapy for Locally
Recurrent Breast Cancer .................................... 449
Hironobu Yanagie
28 Liver Metastases ........................................... 461
A. Zonta, L. Roveda, and S. Altieri
29 Boron Neutron Capture Therapy for Children with Malignant
Brain Tumors ............................................... 505
Yoshinobu Nakagawa and Teruyoshi Kageji
30 Prevention of Vascular Restenosis After Vascular
Angioplasty ................................................ 513
Wataro Tsuruta, Tetsuya Yamamoto, and Akira Matsumura
31 Boron Neutron Capture Synovectomy .......................... 521
Jacquelyn C. Yanch
Part VII Organizational Aspects and Management
32 Managerial Aspects of BNCT at a Nuclear Research Reactor ... 533
Wolfgang A.G. Sauerwein and Ray Moss
Index ......................................................... 543
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