Chemistry and biology of artificial nucleic acids / ed. by M.Egli, P.Herdewijn. - Weinheim: Wiley-VCH, 2012. - x, 558 p.: ill. - Incl. bibl. ref. - Ind.: p.543-558. - Published as a joint publication with Verlag Helvetica Chimica Acta (VHCA), Zurich, Switzerland. - ISBN-10 3-906-390-67-5; ISBN-13 978-3-906-390-67-3  Место хранения:   056 | Институт химической биологии и фундаментальной медицины CO РАН | Новосибирск| Библиотека

Оглавление / Contents

Nucleic Acids with a Six-Membered 'Carbohydrate' Mimic in the Backbone P. Herdewijn ................................................. 1 Oligonucleotide N3' → P5' Phosphoramidates and Thio- Phoshoramidates as Potential Therapeutic Agents S.M. Gryaznov ............................................... 61 From Anionic to Cationic a-Anomeric Oligodeoxynucleotides F. Morvan, F. Debart, J.-J. Vasseur ......................... 79 The Resurgence of Acyclic Nucleic Acids S. Zhang, C. Switzer, J.C. Chaput .......................... 121 Exotic DNAs Made of Nonnatural Bases and Natural Phosphodiester Bonds J. Chiba, M. Inouye ........................................ 135 Locked Nucleic Acids: Promising Nucleic Acid Analogs for Therapeutic Applications R.N. Veedu, J. Wengel ...................................... 159 Peptide Nucleic Acids (PNA) in Chemical Biology and Drug Discovery P.E. Nielsen ............................................... 167 2-Azapurine Nucleosides: Synthesis, Properties, and Base Pairing of Oligonucleotides S. Budow, F. Seela ......................................... 187 An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics T.P. Prakash ............................................... 233 Phosphorothioate Nucleotides and Oligonucleotides - Recent Progress in Synthesis and Application P. Guga, M. Koziołkiewicz .................................. 259 Crystallographic Studies of Chemically Modified Nucleic Acids: A Backward Glance M. Egli, P.S. Pallan ....................................... 299 Selenium Derivatization of Nucleic Acids for X-Ray Crystal- Structure and Function Studies J. Sheng, Z. Huang ......................................... 329 Oligonucleotides with Sugars Other Than Ribo- and 2'-Desoxyribofuranose in the Backbone: the Solution Structures Determined by NMR in the Context of the 'Etiology of Nucleic Acids' Project of Albert Eschenmoser M.-O. Ebert, B. Jaun ....................................... 363 Chemistry and Structural Biology of DNA Damage and Biological Consequences M.P. Stone, H. Huang, K.L. Brown, G. Shanmugam ............. 389 Exploring the Role of Chirality in Nucleic Acid Recognition D. D'Alonzo, A. Guaragna, G. Palumbo ....................... 435 Chemistry on Nucleic Acid Templates J. Berger, M. Oberhuber .................................... 477 Improved Large-Scale Liquid-Phase Synthesis and High- Temperature NMR Characterization of Short (F-)PNAs T.A. Plöger, G. von Kiedrowski ............................. 513 Index ......................................................... 543