Macromolecular anticancer therapeutics / ed. by L.H.Reddy, P.Couvreur. - New York: Springer, 2010. - xx, 623 p.: ill. - (Cancer drug discovery and development). - Incl. bibl. ref. and indexes. - ISBN 978-1-4419-0506-2  Место хранения:   063 | Библиотека по химическим аспектам охраны окружающей среды при Институте органической химии им. Н.Н.Ворожцова. | Новосибирск

Оглавление / Contents

Part I Classification, Opportunities and Challenges 1 Classification of Anticancer Drugs Based on Therapeutic Targets ...................................................... 3 Enrique Espinosa and César Gómez Raposo 2 Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy .............................................. 37 Michele Milella, Ludovica Ciuffreda, and Emilio Bria Part II Polymer-Based Anticancer Prodrugs 3 HPMA-Anticancer Drug Conjugates ............................. 87 B. Rihova, O. Hovorka, L. Kovar, M. Kovar, T. Mrkvan, M. Sirova, V. Subr, and K. Ulbrich 4 Poly-L-Glutamic Acid Anti-cancer Drug Conjugates ........... 133 Jack W. Singer, Marc McKennon, Gabriella Pezzoni, Stefano di Giovine, Mara Cassin, Paola de Feudis, Cecilia Allievi, Patrizia Angiuli, Marco Natangelo, Enrico Vezzali, and Stefano Fazioni 5 Polysaccharide-Based Anticancer Prodrugs ................... 163 Paolo Caliceti, Stefano Salmaso, and Sara Bersani 6 PEG-Anticancer Drugs ....................................... 221 Francesca Cateni and Marina Zacchigna 7 Poly(ethylene glycol)-Protein, Peptide, and Enzyme Conjugates ................................................. 265 E.M. Veronese, G. Pasut, S. Drioli, and G.M. Bonora Part III Lipid-Based Anticancer Prodrugs 8 Lipid-Based Anticancer Prodrugs ............................ 291 L. Harivardhan Reddy and Patrick Couvreur Part IV Antibody-Directed Cancer Therapy 9 Antibody-Cytotoxic Compound Conjugates for Oncology ........ 331 Carol A. Vater and Victor S. Goldmacher 10 Immunoconjugate Anticancer Therapeutics .................... 371 Serengulam V. Govindan and David M. Goldenberg 11 Antibody-Directed Enzyme Prodrug Therapy (ADEPT) for Cancer ..................................................... 393 Surinder К. Sharma and Kenneth D. Bagshawe 12 EGFR-Directed Monoclonal Antibodies ........................ 407 Roberto Bianco, Teresa Gelardi, Sonia Garofalo, Roberta Rosa, and Giampaolo Tortora 13 The Biology of the HER Family and Her2/neu Directed- Antibody Therapy ........................................... 437 Jennifer K. Litton and Gabriel N. Hortobagyi 14 Anti-Vascular Endothelial Growth Factor Monoclonal Antibodies ................................................. 465 Ernest S. Han and Bradley J. Monk 15 Monoclonal Antibody Therapy for Hematologic Malignancies ... 493 Kenneth A. Foon, Michael Boyiadzis, and Samuel A. Jacobs Part V Anticancer Oligonucleotide Therapeutics 16 Anticancer Oligonucleotides ................................ 539 Anne Laure Ramon and Claude Malvy Part VI Miscellaneous 17 New Molecular Therapeutic Interventions: The Case of Breast Cancers ............................................. 571 Véronique Marsaud and Jack-Michel Renoir Author Index .................................................. 613 Subject Index ................................................. 615