Regulation of Adaptive Immunity in the Elderly .................. 1
Nicola J. Booth, Arne N. Akbar, and Milica Vukmanovic-
Stejic
Does Innate Immunity Get Old? .................................. 25
Chiara Romagnani
Thy(-im)munosenescence: The Ageing of the Thymus and Its
Impact on the Immune System .................................... 37
S. Kohler
Characteristics of В Cells and В Cell Responses in Aged
Individuals .................................................... 55
Henrik E. Mei and Andreas Radbruch
Mechanisms of Immune Protection to Pneumococcal Infection
in the Young and the Elderly ................................... 85
Helen E. Baxendale and Jeremy S. Brown
CMV Subversion of the Immune System in Later Life ............. 127
Fiona Powell and Florian Kern
Aging and Autoimmunity ........................................ 145
Ulf Wagner
Vaccination in the Elderly .................................... 157
Birgit Weinberger and Beatrix Grubeck-Loebenstein
Immunosenescence and the 3Rs: Restoration, Replacement
and Reprogramming ............................................. 175
Wayne A. Mitchell, Ryan C. Pink, Antonio Lapenna, and
Richard Aspinall
Novel Strategies for Improved Vaccines for the Elderly:
The Example of Influenza ...................................... 201
Giuseppe Del Giudice and Rino Rappuoli
Index ......................................................... 229
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