Preface ......................................................... v
Contributors ................................................... ix
1 What Is Cancer Nanotechnology? ............................... 1
Stephen R. Grobmyer, Nobutaka Iwakuma, Parvesh Sharma, and
Brij M. Moudgil
2 Molecular-Targeted Therapy for Cancer and Nanotechnology .... 11
Steven N. Hochwald
3 Enhanced Permeability and Retention (EPR) Effect for
Anticancer Nanomedicine Drug Targeting ...................... 25
Khaled Greish
4 Nanoparticle Characterization for Cancer Nanotechnology
and Other Biological Applications ........................... 39
Scott C. Brown, Maria Palazuelos, Parvesh Sharma, Kevin W.
Powers, Stephen M. Roberts, Stephen R. Grobmyer, and Brij
M. Moudgil
5 Multimodal Nanoparticulate Bioimaging Contrast Agents ....... 67
Parvesh Sharma, Amit Singh, Scott C. Brown, Niclas
Bengtsson, Glenn A. Walter, Stephen R. Grobmyer, Nobutaka
Iwakuma, Swadeshmukul Santra, Edward W. Scott, and Brij
M. Moudgil
6 Gold Nanocages for Cancer Imaging and Therapy ............... 83
Leslie Au, Jingyi Chen, Lihong V. Wang, and Younan Xia
7 Nanoshells for Photothermal Cancer Therapy ................. 101
Jennifer G. Morton, Emily S. Day, Naomi J. Halas,
and Jennifer L. West
8 Gold Nanorods: Multifunctional Agents for Cancer Imaging
and Therapy ................................................ 119
Alexander Wei, Alexei P. Leonov, and Qingshan Wei
9 Polymeric Micelles: Polyethylene Glycol-
Phosphatidylethanolamine (PEG-PE)-Based Micelles as an
Example .................................................... 131
Rupa R. Sawant and Vladimir P. Torchilin
10 Fluorescent Silica Nanoparticles for Cancer Imaging ........ 151
Swadeshmukul Santra
11 Polymeric Nanoparticles for Drug Delivery .................. 163
Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang,
Robert Langer, and Omid C. Farokhzad
12 Synthesis, Characterization, and Functionalization of
Gold Nanoparticles for Cancer Imaging ...................... 177
Gary A. Craig, Peter J. Allen, and Michael D. Mason
13 Identification of Pancreatic Cancer-Specific Cell-
Surface Markers for Development of Targeting Ligands ....... 195
David L. Morse, Galen Hostetter, Yoganand Balagurunathan,
Robert J. Gillies, and Haiyong Han
14 Preparation and Characterization of Doxorubicin
Liposomes .................................................. 211
Guoqin Niu, Brian Cogburn, and Jeffrey Hughes
15 PEGylated Nanocarriers for Systemic Delivery ............... 221
N.K. Jain and Manoj Nahar
16 Nanoparticle-Aptamer Conjugates for Cancer Cell
Targeting and Detection .................................... 235
M. Carmen Estévez, Yu-Fen Huang, Huaizhi Kang, Meghan B.
O'Donoghue, Suwussa Bamrungsap, Jilin Yan, Xiaolan Chen,
and Weihong Tan
17 Targeting of Nanoparticles: Folate Receptor ................ 249
Sumith A. Kularatne and Philip S. Low
18 Magnetic Aerosol Targeting of Nanoparticles to Cancer:
Nanomagnetosols ............................................ 267
Carsten Rudolph, Bernhard Gleich, and Andreas W. Flemmer
19 LHRH-Targeted Nanoparticles for Cancer Therapeutics ........ 281
Tamara Minko, Mahesh L. Patil, Min Zhang, Jayant J.
Khandare, Maha Saad, Pooja Chandna, and Oleh Taratula
20 Antibody Targeting of Nanoparticles to Tumor-Specific
Receptors: Immunoliposomes ................................. 295
Miriam Rothdiener, Julia Beuttler, Sylvia K.E.
Messerschmidt, and Roland E. Kontermann
21 Photoacoustic Tomography for Imaging Nanoparticles ......... 309
Zhen Yuan and Huabei Jiang
22 Current Applications of Nanotechnology for Magnetic
Resonance Imaging of Apoptosis ............................. 325
Gustav J. Strijkers, Geraida A.F. van Tilborg, Tessa
Geelen, Chris P.M. Reutelingsperger, and Klaas Nicolay
23 Applications of Gold Nanorods for Cancer Imaging and
Photothermal Therapy ....................................... 343
Xiaohua Huang, Ivan H. El-Sayed, and Mostafa A.. El-Sayed
24 Use of Nanoparticles for Targeted, Noninvasive Thermal
Destruction of Malignant Cells ............................. 359
Paul Cherukuri and Steven A. Curley
25 Colloidal Gold: A Novel Nanoparticle for Targeted Cancer
Therapeutics ............................................... 375
Anathea С. Powell, Giulio F. Paciotti, and Steven
K. Libutti
26 Liposomal Doxorubicin and nab-Paclitaxel: Nanoparticle
Cancer Chemotherapy in Current Clinical Use ................ 385
Alexander Gaitanis and Stephen Staal
Subject Index ................................................. 393
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