RNA interference: application to drug discovery and challenges to pharmaceutical development / ed. by P.H.Johnson. - Hoboken: Wiley, 2011. - xiv, 310 p.: ill. - Ind.: p.307-310. - ISBN 978-0-471-77151-7  Место хранения:   056 | Институт химической биологии и фундаментальной медицины CO РАН | Новосибирск| Библиотека

Оглавление / Contents

CONTRIBUTORS .................................................. vii PREFACE ........................................................ ix FOREWORD ..................................................... xiii I BIOLOGY OF RNA INTERFERENCE .................................. 1 1 RNA INTERFERENCE: WHAT IS IT? ................................ 3 James A. Birchler 2 NUCLEIC ACIDS AS REGULATORY MOLECULES ....................... 12 Faqing Huang, C. J. Yu, and Yanlin Guo 3 USE OF siRNA OLIGONUCLEOTIDES TO STUDY GENE FUNCTION ............................................... 50 Kristin A. Wiederholt and Adam N. Harris 4 GENOME SCANNING BY RNA INTERFERENCE ......................... 76 Roderick L. Beijersbergen and Oliver C. Steinbach II DEVELOPMENT OF siRNA FOR THERAPEUTIC APPLICATIONS ............................................... 123 5 DISCOVERY OF NEW SiRNA DELIVERY AGENTS ..................... 125 Paul H. Johnson, Diane Frank, Kunyuan Cui, Roger Adami, Harry Wang, Michael Houston, and Steven C. Quay 6 siRNA DELIVERY VEHICLES .................................... 174 Aliasger К. Salem and Mark A. Behlke 7 INTERFERON, CYTOKINE INDUCTION, AND OTHER POTENTIAL IN VIVO TOXICITIES ............................... 216 Adam Judge, Marjorle Robbins, and Ian Maclachlan 8 APPLICATION OF RNA INTERFERENCE TO VIRAL DISEASES .......................................... 272 Ralph A. Tripp and Stephen Mark Tompkins INDEX ......................................................... 307