Preface ........................................................ ix
Editor ......................................................... xi
Contributors ................................................. xiii
Chapter 1 Folate Chemistry and Metabolism ...................... 1
Barry Shane
Chapter 2 Folate Bioavailability .............................. 25
Helene McNulty and Kristina Pentieva
Chapter 3 Folate Biochemical Pathways and Their Regulation .... 49
Patrick J. Stover
Chapter 4 Genetic Variation: Effect on Folate Metabolism
and Health .......................................... 75
Karen E. Christensen and Rima Rozen
Chapter 5 Folate in Pregnancy and Lactation .................. 111
Tsunenobu Tamura, Mary Frances Picciano, and
Michelle Kay McGuire
Chapter 6 Folate Status and Birth Defect Risk:
Epidemiological Perspective ........................ 133
Charlotte A. Hobbs, Gary M. Shaw, Martha M.
Werter, and Bridget Mosley
Chapter 7 Folate-Related Birth Defects: Embryonic
Consequences of Abnormal Folate Transport and
Metabolism ......................................... 155
Deeann Wallis, Johnathan L. Ballard, Gary M.
Shaw, Edward J. Lammer, and Richard H. Finnell
Chapter 8 Folic Acid Fortification: Neural Tube Defect Risk
Reduction - A Global Perspective ................... 179
Robert J. Berry, Joseph Mulinare, and Heather
C. Hamner
Chapter 9 Folate and Cancer: Epidemiological Perspective ..... 205
Jia Chen, Xinran Xu, Amy Liu, and Cornelia
M. Ulrich
Chapter 10 Folate and Carcinogenesis: Basic Mechanisms ........ 235
Eric Ciappio and Joel B. Mason
Chapter 11 Folate and Vascular Disease: Epidemiological
Perspective ........................................ 263
Sari R. Kalin and Eric B. Rimm
Chapter 12 Folate and Vascular Disease: Basic Mechanisms ...... 291
Luciana Hannibal, Alia V. Glushchenko, and Donald
W. Jacobsen
Chapter 13 Folate and Neurological Function: Epidemiological
Perspective ........................................ 325
Martha Savaria Morris and Paul F. Jacques
Chapter 14 Folate and Neurological Disease: Basic
Mechanisms ......................................... 355
Teodoro Bottiglieri and Edward Reynolds
Chapter 15 Folate-Vitamin B12 Interrelationships: Links to
Disease Risk ....................................... 381
Anne M. Molloy
Chapter 16 Clinical Folate Deficiency ......................... 409
Sally P. Stabler
Chapter 17 Influence of Alcohol on Folate Status and
Methionine Metabolism in Relation to Alcoholic
Liver Disease ...................................... 429
Charles H. Halsted, Valentina Medici, and Farah
Esfandiari
Chapter 18 Folate and Choline Interrelationships: Metabolic
and Potential Health Implications .................. 449
Marie A. Caudill
Chapter 19 Folate: Recommended Intakes, Consumption, and
Status ............................................. 467
Gail P.A. Kauwell, Megan L. Diaz, Quanhe Yang,
and Lynn B. Bailey
Chapter 20 Kinetics of Folate and One-Carbon Metabolism ....... 491
Jesse F. Gregory III, Vanessa R. da Silva, and
Yvonne Lamers
Chapter 21 Folate Analytical Methodology ...................... 517
Christine M. Pfeiffer, Zia Fazili, and Mindy
Zhang
Index ......................................................... 575
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