Garcia-Segura L.M. Hormones and brain plasticity. - Oxford; New York: Oxford University Press, 2009. - xiv, 482 p., [8] p. of plates: ill. (some col.). - (Oxford series in behavioral neuroendocrinology). - Bibliogr.: p.309-443. - Auth. ind.: p.445-462. - Sub. ind.: p.463-482. - ISBN 978-0-19-532661-1  Место хранения:   07 | Центральная библиотека Красноярского научного центра СО РАН | Красноярск

Оглавление / Contents

Preface and Acknowledgments .................................. xiii Chapter 1 Hormones and the Mutable Brain ....................... 3 Introduction: Endocrine Glands, Brain Plasticity, Homeostasis, Allostasis, and Homeodynamics ................... 3 Hie Nervous System is in a Constant State of Remodeling: Cellular Plasticity and Cellular Replacement ................. 8 The Classic Concept of Brain Plasticity: Cajal's Heritage ... 11 Cellular Replacement: A New Concept 15 Role of Hormones on Brain Mutability: Plasticity and Metaplasticity ............. 16 Chapter 2 Brain Plasticity Regulates Hormonal Homeodynamics ... 21 Introduction: Brain Plasticity Regulates the Activity of Endocrine Glands ............................................ 21 Neuroglial Remodeling Associated with Hormonal Secretion by Hypothalamic Magnocellular Neurons ....................... 23 Neuroglial Remodeling in the Neurohypophysis ................ 29 Neuroglial Remodeling Associated with Parvocellular Hypothalamic Neurons ........................................ 30 Neuroglial Remodeling in the Median Eminence ................ 34 Brain Plasticity and the Control of Hormonal Homeodynamics: A Recapitulation ............................. 41 Chapter 3 Hormonal Influences on Brain Plasticity: I. Melatonin, Thyroid Hormones and Corticosteroids .......... 43 Introduction: A Large Variety of Hormones Regulate Brain Plasticity .................................................. 43 Hormones or Paracrine Factors? .............................. 47 Melatonin ................................................... 48 Thyroid Hormones ............................................ 51 Stress, Corticosteroids, and Brain Plasticity ............... 53 Chapter 4 Hormonal Influences on Brain Plasticity: II. Sex Hormones ............................................ 65 Introduction: Sex Hormones and Brain Remodeling ............. 65 The First Evidences ......................................... 65 Regulation by Estradiol and Progesterone of Synaptic and Glial Remodeling in the Arcuate Nucleus ..................... 69 Regulation by Estradiol and Progesterone of Synaptic Remodeling in the Ventromedial Hypothalamic Nucleus ......... 78 Regulation by Estradiol and Progesterone of Synaptic Remodeling in the Hippocampus ............................... 79 Regulation by Estradiol and Progesterone of Glial Remodeling in the Hippocampus ............................... 86 Regulation by Estradiol and Progesterone of Adult Neurogenesis ................................................ 88 Role of Brain Estradiol Synthesis in the Regulation of Synaptic Plasticity and Neuronal Replacement ................ 91 Androgens, Synaptic Plasticity, and Cellular Replacement in the Song System of Songbirds ............................. 96 Androgens and Synaptic Plasticity in Motoneurons ............ 98 Androgens, Synaptic plasticity, and Cellular Replacement in the Mammalian Brain ...................................... 99 Chapter 5 Hormonal Influences on Brain Plasticity: III. Peptide Hormones ...................................... 105 Introduction: Peptide Hormones as Regulators of Brain Remodeling ................................................. 105 Vasopressin and Oxytocin ................................... 106 Corticotropin-Releasing Hormone and Urocortins ............. 108 Prolactin .................................................. 111 Gonadotropin-Releasing Hormone ............................. 112 Insulin .................................................... 113 Growth Hormone/Insulin-Like Growth Factor-I ................ 118 Insulin-Like Growth Factor-I and Synaptic Plasticity ....... 120 Insulin-Like Growth Factor-I and Adult Neurogenesis ........ 122 Interactions of Insulin-Like Growth Factor-I and Estradiol in the Regulation of Brain Plasticity ...................... 125 Erythropoietin ............................................. 131 Angiotensin ................................................ 133 Feeding Hormones: Leptin, Ghrelin and Glucagon-Like Peptide-1 .................................................. 134 Hormonal Influences on Brain Plasticity: Recapitulation of the Chapters 3,4 and 5 .................................. 139 Chapter 6 Life Stages, Hormones, and Brain Remodeling: Early Hormonal Influences on Brain Mutability .............. 141 Introduction: Hormonal Imprinting of the Nervous System .... 141 Hormonal Orchestration of Neural Development during Prenatal Life .............................................. 145 Thyroid Hormones ........................................... 145 Sex Hormones ............................................... 147 Enduring Effects of Prenatal Stress ........................ 151 Peptide Hormones ........................................... 154 Hormonal Regulation of Brain Mutability during Early Postnatal Life ............................................. 156 Metamorphosis in Vertebrates ............................... 156 Thyroid Hormone Regulation of Postnatal Brain Development in Non-Metamorphic Vertebrates ............................. 158 Gonadal Hormones ........................................... 159 Stress Hormones ............................................ 169 Peptide Hormones ........................................... 171 Early Hormonal Influences on Brain Mutability: Recapitulation ............................................. 174 Chapter 7 Life Stages, Hormones, and Brain Remodeling: The Transition from Childhood to Adulthood ..................... 177 Introduction: Prepubertal Maturation, Puberty, and Adolescence ................................................ 177 Brain Remodeling during the Transition from Childhood to Adulthood .................................................. 178 Hormones as Regulators of Brain Plasticity during Prepubertal Maturation, Puberty, and Adolescence ........... 182 Brain Remodeling as a Cause of Hormonal Changes during Puberty .................................................... 186 Chapter Summary ............................................ 190 Chapter 8 Life Stages, Hormones, and Brain Remodeling: Adult Reproductive Life .................................... 193 Introduction: Hormonal Regulation of Brain Plasticity during Adult Life .......................................... 193 Hormones and Circadian Brain Plasticity .................... 197 Hormones and Seasonal Brain Plasticity ..................... 200 Seasonal Brain Plasticity in the Song System of Songbirds .................................................. 203 Extreme Seasonal Brain Plasticity in Mammals: Hibernation ................................................ 207 Brain Plasticity and the Control of Hormonal Homeodynamics in Seasonal Breeders ......................... 212 Brain Plasticity and Reproductive Cycles in Nonseasonal Breeders ................................................... 213 Brain Structures Controlling GnRH Neurons .................. 213 The Ventromedial Hypothalamic Nucleus ...................... 220 The Hippocampus ............................................ 221 Hormones and Brain Remodeling during Motherhood ............ 222 Social Interactions, Hormones, and Brain Plasticity ........ 226 Traumatic Experiences, Hormones, and Brain Plasticity ...... 228 Chapter Summary ............................................ 230 Chapter 9 Life Stages, Hormones, and Brain Remodeling: Disease and Neuroprotection ................................ 231 Introduction: Altered Cross Talk between Endocrine Glands and the Brain under Pathological Conditions ................ 231 Pathological Brain Remodeling Affects Hormonal Secretions ................................................. 232 Pathological Alterations in Hormonal Levels or Hormonal Signaling Affect Brain Plasticity .......................... 235 Hormones Regulate Plasticity and Exert Neuroprotective Actions in the Injured Brain ............................... 239 Peptide Hormones ........................................... 240 Melatonin and Thyroid Hormones ............................. 244 Steroid Hormones ........................................... 245 Glucocorticoids ............................................ 245 Dehydroepiandrosterone ..................................... 246 Sex Steroids ............................................... 247 Progesterone ............................................... 248 Estradiol and Estrogens .................................... 251 Testosterone ............................................... 264 Neurosteroids .............................................. 269 Chapter Summary ............................................ 274 Chapter 10 Life Stages, Hormones, and Brain Remodeling: Aging ...................................................... 275 Introduction: Changes in Brain Plasticity and Endocrine Function with Aging ........................................ 275 Biological Significance of Endocrine Function Changes with Aging ................................................. 283 Brain Mutability Regulates Aging-Associated Changes in Endocrine Function ...................................... 284 Hormones Regulate Aging-Associated Changes in Brain Mutability ................................................. 285 A Paradox: Unexpected Relations between Brain Aging, Hormones, and Longevity .................................... 288 Hormone Therapy and Healthy Brain Aging .................... 292 Does Aging Affects Brain Responsiveness to Hormones? ....... 296 Does the Brain Have Mechanisms to Counterbalance Hormonal Changes with Aging? ............................... 299 Opportunities for Therapeutic Intervention: Hormone Therapies and Beyond ....................................... 302 Hormones and Brain Aging: Summary .......................... 304 Concluding Summary ......................................... 307 Bibliography .................................................. 309 Author Index .................................................. 445 Subject Index ................................................. 463