Foreword ....................................................... xv
Autoantibodies: History and Horizons
Noel R. Rose
Preface ....................................................... xix
About the Editors ............................................. xxi
List of Contributors ........................................ xxiii
Introduction ............................................... xxxiii
I INTRODUCTION: AUTOANTIBODIES-UNIQUE CHARACTERISTICS
1 What is an Autoantibody? ..................................... 3
Sabine Oertelt, Pietro Invernizzi, Mauro Podda, and
M. Eric Gershwin
2 Natural Autoantibodies, Heralding, Protecting and Inducing
Autoimmunity ................................................. 7
Howard Amital and Yehuda Shoenfeld
3 Molecular Mimicry ........................................... 13
Lisa K. Peterson and Robert S. Fujinami
4 Affinity and Avidity of Autoantibodies ...................... 21
Borut Božič, Saša Čučnik, Tanja Kveder, and Blaž Rozman
5 Pathogenic Mechanisms and Clinical Relevance of
Autoantibodies .............................................. 29
Ricard Cervera and Yehuda Shoenfeld
6 Native Autoantigens Versus Recombinant Autoantigens ......... 37
Patrick S.C. Leung and M. Eric Gershwin
7 Redox-Reactive Autoantibodies ............................... 47
John A. Mclntyre, Dawn R. Wagenknecht, and W. Page Faulk
8 Predictive Autoantibodies ................................... 55
Michal Harel and Yehuda Shoenfeld
9 Autoantibody Subclasses ..................................... 61
Pierre Youinou, Maryvonne Dueymes, and Yehuda Shoenfeld
10 Idiotypes and Anti-Idiotypes ................................ 69
Mahmoud Abu-Shakra and Yehuda Shoenfeld
11 Novel Diagnostic Methods for Autoantibody Detection ......... 77
Renato Tozzoli and Nicola Bizzaro
II ALLERGIC DISEASE AUTOANTIBODIES
12 Human IgE-Specific Autoantibodies and Autoantibodies to
IGE Receptors ............................................... 85
Ivo Lochman, Alexandra Lochmanová, Robert G. Hamilton, and
Beda M. Stadler
III ANTINEUTROPHIL ANTIBODIES
13 Antineutrophil Cytoplasmic Autoantibodies with
Specificity for Myeloperoxidase ............................. 95
Cees G.M. Kallenberg
14 Antineutrophil Cytoplasmic Autoantibodies with
Specificity for Proteinase 3 ............................... 105
Antonella Radice, Ettore Sabadini, and Renato Alberto
Sinico
15 Neutrophil-Specific Antinuclear and Anti-cytoplasmic
Antibodies in Chronic Inflammatory Diseases ................ 111
Allan Wiik
16 Antineutrophil Cytoplasmatic Autoantibodies with
Specificity to Proteinase 3 ................................ 119
Peer M. Aries, Elena Csernok, and Wolfgang L. Gross
IV INTRODUCTION: ANTINUCLEAR ANTIBODIES
17 Antinuclear Antibodies: General Introduction ............... 129
Pietro Invernizzi
18 Antinucleolar Antibodies ................................... 135
Sabine Oertelt, Mauro Podda, and M. Eric Gershwin
19 Anti-Chromatin (Nucleosome) Autoantibodies ................. 141
Danilo Villalta and Renato Tozzoli
20 Centromere Autoantibodies .................................. 151
Neil John McHugh
21 dsDNA Autoantibodies ....................................... 159
Dörte Hamann and Ruud J.T. Smeenk
22 Histone Autoantibodies ..................................... 169
Hélène Dumortier and Sylviane Muller
23 Ku and Ki Autoantibodies ................................... 177
Haoyang Zhuang, Sonali Narain, Anthony Chin Loy, Minoru
Satoh, and Westley H. Reeves
24 Neuronal Nuclear Autoantibodies, Type 1 (HU) ............... 185
Luigi Zuliani and Francesc Graus
25 Nuclear Envelope Protein Autoantibodies/Antilamin
Autoantibodies ............................................. 191
Pietro Invernizzi and Józefa Wesierska-Gadek
26 Anti-Nucleosome Autoantibodies ............................. 197
Casandra C. Van Bavel, Johan ver der Vlag, and Jo
H. Berden
27 Proliferating Cell Nuclear Antigen Autoantibodies .......... 205
Gail A. McCarty
28 Anti-RA33 Antibodies (Antibodies to the Heterogeneous
Nuclear Ribonucleoprotein A2) .............................. 211
Günter Steiner and Josef S. Smolen
29 Anti-Ribosomal P Antibodies ................................ 217
Gisele Zandman-Goddard and Yehuda Shoenfeld
30 SS-A (Ro) Autoantibodies ................................... 225
Morris Reichlin and R. Hal Scofield
31 Topoisomerase-I (Scl-70) Autoantibodies .................... 231
Silvia Bellando Randone, Serena Guiducci, and Marco
Matucci Cerinic
32 SS-B (La) Autoantibodies ................................... 239
John G. Routsias and Athanasios G. Tzioufas
33 Anti-RNA Polymerase III Antibodies ......................... 247
Renato Tozzoli and Danilo Villalta
V AUTOANTIBODIES TO BIOLOGIC FACTORS/STRUCTURES
34 GW Bodies, P Bodies and Components of the miRNA Pathway .... 257
Marvin J. Fritzler and Edward K.L. Chan
35 Golgi Complex and Endosome Antibodies ...................... 263
Marvin J. Fritzler and Edward K.L. Chan
36 p53 Autoantibodies ......................................... 271
Johannes Herkel and Irun R. Cohen
37 Human Antiganglioside Autoantibodies ....................... 277
Mepur H. Ravindranath and Rajeswari M.H. Ravindranath
38 Human Anti-ct-Galactosyl Antibodies ........................ 285
Mepur H. Ravindranath and Sakunthala Muthugounder
39 Autoantibodies in Therapeutic Preparations of Human
Intravenous Immunoglobulin (IVIG) .......................... 293
Philippe Guilpain, Srinivas V. Kayeri, and Luc Mouthon
40 Cytokine Antibodies ........................................ 299
Klaus Bendtzen and Morten Svenson
41 Cytoskeletal Autoantibodies/Anti-Actin Antibodies .......... 309
Christopher A. Aoki and Christopher L. Bowlus
42 Fibrillarin Autoantibodies ................................. 317
K. Michael Pollard and Per Hultman
43 Fibronectin Autoantibodies ................................. 325
Eugen Feist and Falk Hiepe
44 Interferon-Inducible Protein IFI16 Autoantibodies .......... 331
Piersandro Riboldi, Maria Gerosa, Michele Mondini, and
Santo Landolfo
VI CARDIAC AUTOANTIBODIES
45 Autoantibodies in Atherosclerosis .......................... 341
Johan Frostegård
46 Heat Shock Protein Autoantibodies .......................... 349
Georg Wick, Michaela Kind, and Michael Knoflach
47 Myocardial Autoantibodies and their Clinical
Significance ............................................... 355
Aftab A. Ansari, J. Bruce Sundstrom, Olaf Forster,
Denise Hilfiker-Kleiner, and Karen Sliwa
VII ENDOCRINE AUTOANTIBODIES
48 Glutamic Acid Decarboxylase Autoantibodies ................. 369
Christian Krueger, Winfried Stöcker, and Michael
Schlosser
49 Humoral Immunity in Type 1 Diabetes Mellitus ............... 379
Massimo Pietropaolo and Mark A. Sperling
50 Antibodies to Adrenal, Gonadal Tissues and Steroidogenic
Enzymes .................................................... 389
Corrado Betterle, Renato Zanchetta, Shu Chen, and
Jadwiga Furmaniak
51 Thyroglobulin, Thyroperoxidase, and Thyrotropin-Receptor
Autoantibodies ............................................. 403
C. Lynne Burek, Noel R. Rose, and Patrizio Caturegli
VIII GI AND LIVER AUTOANTIBODIES
52 Anti-Intestinal Goblet Cell Antibodies ..................... 417
Karsten Conrad, Michael Bachmann, and Winfried Stöcker
53 Tumor-Associated Autoantibodies ............................ 423
Karsten Conrad and Michael Bachmann
54 Cryoglobulins and Cryoglobulins Secondary to Hepatitis
С Virus Infection .......................................... 437
Suk Seo and Natalie Torok
55 Anti-Tissue Transglutaminase and Anti-Endomyisial
Antibodies ................................................. 443
E. Tonutti and N. Bizzaro
56 Anti-Gliadin Antibodies .................................... 451
Nicola Bizzaro and Elio Tonutti
57 Reticulin Autoantibodies ................................... 457
Danilo Villalta and Elio Tonutti
58 Liver Cytosol Antigen Type 1 Autoantibodies, Liver Kidney
Microsomal Autoantibodies, and Liver Microsomal
Autoantibodies ............................................. 463
Christian P. Strassburg and Michael P. Manns
59 Antimitochondrial Antibodies ............................... 473
Pietro Invernizzi, Carlo Selmi, and M. Eric Gershwin
60 Parietal Cell and Intrinsic Factor Autoantibodies .......... 479
Ban-Hock Toh and Frank Alderuccio
61 Smooth Muscle Antibodies ................................... 487
Carlo Selmi, Paolo Muratori, Mauro Podda, and Francesco
B. Bianchi
IX HEMATOLOGIC AUTOANTIBODIES
62 Coagulation Factor Autoantibodies .......................... 495
Jean Guy Gilles and Jean-Marie Saint-Remy
63 Autoantibodies in Heparin-Induced Thrombocytopenia ......... 511
Gowthami Arepally, Mortimer Poncz, and Douglas B. Cines
64 Platelet Autoantibodies .................................... 521
Boris Shenkman, Nurit Rosenberg, and Ophira Salomon
65 Red Cell Autoantibodies .................................... 529
Urs E. Nydegger and Shozo Izui
66 Lymphocytotoxic Autoantibodies ............................. 537
Yves Renaudineau, M. Eric Gershwin, and Pierre Youinou
X KIDNEY AUTOANTIBODIES
67 Anti-ATP Synthase β-Chain Autoantibodies ................... 547
Luca Musante, Giovanni Candiano, Maurizio Bruschi,
Laura Santucci, and Gian Marco Ghiggeri
68 Glomerular Basement Membrane Autoantibodies ................ 553
Thomas Hellmark and Mårten Segelmark
69 Nephritic Factor Autoantibodies ............................ 561
George C. Tsokos
XI NEUROLOGICAL SYSTEM AUTOANTIBODIES
70 Acetylcholine Receptor and Muscle Specific Kinase
Autoantibodies ............................................. 569
Angela Vincent
71 Myositis Autoantibodies: Aminoacyl-tRNA Synthetase,
Signal Recognition Particle, Mi-2, and PM-Scl
Autoantibodies ............................................. 577
Ira N. Targoff
72 Anti-MOG Antibodies ........................................ 591
Ulrich Wurster, Ralf-Björn Lindert, Isabel Torens, and
Fedor Heidenreich
73 Antibodies to Hsp 70 in Inner Ear Disease .................. 599
Renato Tozzoli and Graziano Kodermaz
74 Autoantibodies in the Lambert-Eaton Myasthenic Syndrome
(LEMS) and Amyotrophic Lateral Sclerosis (ALS) ............. 605
Bethan Lang
75 Ganglioside Autoantibodies ................................. 611
Hugh J. Willison
76 Myelin Associated Antibodies: Myelin-Associated
Glycoprotein Autoantibodies, Myelin Basic Protein
Autoantibodies and Myelin Proteolipid Autoantibodies
in Neurologic Diseases ..................................... 619
A. Achiron and S. Miron
77 Paraneoplastic Neurological Antibodies: Nuclear ............ 627
Abid R. Karim, Richard G. Hughes, Mohammed El Lahawi,
and Arthur R. Bradwell
78 Paraneoplastic Neurological Antibodies: Purkinje Cell
Cytoplasm .................................................. 637
Abid R. Karim, Richard G. Hughes, Mohammed El Lahawi,
and Arthur R. Bradwell
79 Paraneoplastic Neurological Antibodies: Additional
Reactivities ............................................... 645
Abid R. Karim, Richard G. Hughes, Mohammed El Lahawi,
and Arthur R. Bradwell
80 Retinal Autoantibodies ..................................... 653
Guy V. Jirawuthiworavong, Grace A. Levy-Clarke,
and Robert B. Nussenblat
81 Autoantibodies in Epilepsy ................................. 659
Bethan Lang and Angela Vincent
XII RHEUMATIC DISEASE AUTOANTIBODIES
82 Anti-Fodrin Antibodies ..................................... 669
Torsten Witte
83 Antibodies to Laminin ...................................... 675
Rina Ulmansky, Alon Y. Hershko, and Yaakov Naparstek
84 Autoantibodies Against Muscarinic Acetylcholine Receptor
in Patients with Sjögren's Syndrome ........................ 681
Takayuki Sumida, Ei Wakamatsu, Tomomi Nakamura, and Isao
Matsumoto
85 β2-Glycoprotein I Autoantibodies ........................... 687
Eiji Matsuura, Ken J. Dier, and Luis R. Lopez
86 CI Inhibitor Autoantibodies ................................ 695
Marco Cicardi and Lorenza C. Zingale
87 Autoantibodies to C1q ...................................... 703
Mark H. Wener
88 Anti-Collagen Antibodies ................................... 713
Alon Y. Hershko, Rina Ulmansky, and Yaakov Naparstek
89 Anti-Cyclic Citrullinated Peptide Antibody ................. 721
Stanley M. Naguwa
90 Anti-Endothelial Cell Autoantibodies ....................... 725
Nicoletta Ronda, Pier Luigi Meroni, Elena Raschi, and
Maria O. Borghi
91 Lupus Anticoagulant Testing ................................ 733
Vittorio Pengo and Amelia Ruffatti
92 Anticardiolipin Antibodies ................................. 741
Munther A. Khamashta and Maria Laura Bertolaccini
93 Phospholipid Autoantibodies (Non-Anticardiolipin)-Anti-
Prothrombin Antibodies ..................................... 747
Monica Galli
94 Rheumatoid Factors ......................................... 755
Valentina De Angelis and Pier Luigi Meroni
XIII SKIN DISEASE AUTOANTIBODIES
95 Autoantibodies to Mucocutaneous Antigens ................... 765
Sergei A. Grando
XIV UNIQUE CLINICAL SITUATIONS
96 Autoimmunity and the Newer Biopharmaceuticals .............. 783
Fabiola Atzeni and Piercarlo Sarzi-Puttini
97 Autoantibodies Against Tumor Suppressor Proteins ........... 793
Yih-Hsin Chang, Ming-Lib Haung, and Ming-Yuh Shiau
98 Detection of Autoantibodies Using Protein Arrays ........... 799
Tony Prestigiacomo and Steven R. Binder
99 Autoantibodies and Pregnancy Loss .......................... 809
H.J.A. Carp
XV FUTURE DIRECTIONS
100 Anti-Glycan Antibodies .................................... 817
Nir Dotan
101 Future Trends ............................................. 823
Pier Luigi Meroni, Valentina De Angelis, and Francesco
Tedesco
Index ......................................................... 827
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