List of Contributors .......................................... vii
Foreword ..................................................... xiii
Preface ...................................................... xvii
Section 1 Normal developmental processes ....................... 1
Introduction to Section 1 .................................... 3
1 Morphological development of the brain: what has imaging
told us? ..................................................... 5
Lisa H. Lu and Elizabeth R. Sowell
2 Neural correlates of the development of cognitive control ... 22
Silvia A. Bunge and Eveline A. Crone
3 Neurobiology of emotion regulation in children and adults ... 38
Ian H. Gotlib and Jutta Joormann
4 Goal-directed behavior: evolution and ontogeny .............. 53
Monique Ernst and Michael G. Hardin
5 Charting brain mechanisms for the development of social
cognition ................................................... 73
Kevin A. Pelphrey and Susan B. Perlman
6 Language and the developing brain: insights from
neuroimaging ................................................ 91
Kristin McNealy, Mirella Dapretto and Susan Bookheimer
Section 2 Atypical processes in developmental
neuropsychiatric disorders ......................... 109
Introduction to Section 2 .................................. 111
7 A pathophysiology of attention deficit/hyperactivity
disorder: clues from neuroimaging .......................... 113
Jeffery N. Epstein
8 Brain imaging of autism spectrum disorders ................. 130
Monica Zilbovicius, Nathalie Boddaert and Nadia Chabane
9 Neuroimaging of schizophrenia and its development .......... 147
Matcheri S. Keshavan, Vaibhav A. Diwadkar, Konasale
Prasad and Jeffrey A. Stanley
10 Cortico-limbic development in bipolar disorder:
a neuroimaging view ........................................ 161
Jessica H. Kalmar, Maulik P. Shah and Hilary P. Blumberg
11 Anxiety and depressive disorders ........................... 183
Daniel S. Pine
12 Disturbances of fronto-striatal circuits in Tourette
syndrome and obsessive-compulsive disorder ................. 199
Rachel Marsh, Daniel A. Gorman, Jason Royal and Bradley
S. Peterson
13 From genes to brain to behavior: the case of fragile X
syndrome ................................................... 217
Susan M. Rivera and Allan T. Reiss
14 Alcohol exposure and the developing human brain ............ 229
James M. Bjork
15 Neuroimaging as a tool for unlocking developmental
pathophysiology in anorexia and bulimia nervosa ............ 245
Guido K.W. Frank and Walter H. Kaye
Section 3 Ethical issues ..................................... 259
Introduction to Section 3 .................................. 261
16 Legal and ethical considerations in pediatric
neuroimaging research ...................................... 263
Clinton D. Hermes
Section 4 Techniques and integration with other research
approaches ......................................... 277
Introduction to Section 4 .................................. 279
17 BOLD fMRI: an update with emphasis on pediatric
applications ............................................... 281
Fiat Levita, Rebecca M. Jones and B.J. Casey
18 Magnetic resonance spectroscopy: methods and applications
in developmental clinical neuroscience ..................... 296
Marisa M. Silveri, Deborah Yurgelun-Todd and Perry
Renshaw
19 Diffusion tensor imaging in developmental clinical
neuroscience ............................................... 314
Dae-Shik Kim
20 Arterial spin labeling perfusion magnetic resonance
imaging in developmental neuroscience ...................... 326
Jiong-Jiong Wang, Hengyi Rao and John A. Detre
21 Neuroimaging of treatment effects in developmental
neuropsychiatric disorders ................................. 344
Steven R. Pliszka and David С. Glahn
22 Functional alleles, neuroimaging and intermediate
phenotypes in the deconstruction of complex behavioral
variation .................................................. 365
David Goldman, Beata Buzas and Ke Xu
Section 5 Progress and future directions ..................... 383
Introduction to Section 5 .................................. 385
23 Neuroimaging in developmental clinical neuroscience
today ...................................................... 387
Judith M. Rumsey and Monique Ernst
Appendix A: Functional MRI educational resources and
software .......................................... 401
Appendix B: Neuroinformatics and neuroethics resources ........ 403
Glossary ...................................................... 407
Index ......................................................... 437
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