Contributors ................................................. xiii
Part I Overview and New Detection Method
1 The Current Status of DNA Microarrays ........................ 3
Leming Shi, Roger G. Perkins, and Weida Tong
2 Electrochemical Detection on Microarrays .................... 25
Kilian Dill and Andrey Ghindilis
Part II Fluidic Manipulation and Microarrays
3 Fully Integrated Microfluidic Device for Direct
Sample-to-Answer Genetic Analysis ........................... 37
Robin H. Liu and Piotr Grodzinski
4 Integrated Microfluidic Devices for Automated Microarray-
Based Gene Expression and Genotyping Analysis ............... 67
Robin H. Liu, Mike Lodes, H. Sho Fuji, David Danley, and
Andrew McShea
Part III Statistical Data Evaluation on Microarrays
5 Intensity Concentration Relationships for Electrochemical
Detection: Latin Square and Mixture Analysis ................ 97
Mervyn Thomas
Part IV Applications
6 Genotyping Arrays .......................................... 121
Michael J. Lodes, Dominic Suciu, David Danley, and Andrew
McShea
7 Peptide-Based Microarray ................................... 139
Resmi C. Panicker, Hongyan Sun, Grace Y.J. Chen, and
Shao Q. Yao
8 Protein Microarrays for the Detection of Bio threats ....... 169
Amy E. Herr
9 Photo-Generation of Carbohydrate Microarrays
Gregory T. Carroll, Denong Wang, Nicholas J. Turro, and
Jeffrey T. Koberstein
10 Expression Profiling Using Microfluidic Living Cell
Arrays ..................................................... 211
Kevin R. King, Martin L. Yarmush, and Arul Jayaraman
11 New Approaches to the Synthesis of Addressable
Microarray Molecular Libraries ............................. 227
Karl Maurer and Kevin D. Moeller
12 eSensor®: A Microarray Technology Based on
Electrochemical Detection of Nucleic Acids and Its
Application to Cystic Fibrosis Carrier Screening ........... 247
Michael R. Reed and William A. Coty
Part V Future Improvements in Microarray Sensing
13 Use of Redox Enzymes for the Electrochemical Detection
of Sequence-Specific DNA and Immunochemical Entities ....... 263
Kilian Dill and Andrey Ghindilis
14 Biochip Platforms for Dna Diagnostics ...................... 271
Anil K. Deisingh, Adilah Guiseppi-Wilson, and Anthony
Guiseppi-Elie
15 MagArray Biochips for Protein and DNA Detection with
Magnetic Nanotags: Design, Experiment, and
Signal-to-Noise Ratio ...................................... 299
Sebastian J. Osterfeld and Shan X. Wang
16 Bar Coding Platforms for Nucleic Acid and Protein
Detection .................................................. 315
Uwe R. Müller
17 Electrochemical Nanoparticle-Based Sensors ................. 339
Joseph Wang
Index ......................................................... 355
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