Preface
Past, Present, and Future Triumphs of Biochemistry
JoAnne Stubbe ................................................ v
Prefatory
From Serendipity to Therapy
Elizabeth F. Neufeld ......................................... 1
Journey of a Molecular Biologist
Masayasu Nomura ............................................. 16
My Life with Nature
Julius Adler ................................................ 42
Membrane Vesicle Theme
Protein Folding and Modification in the Mammalian Endoplasmic
Reticulum
Ineke Braakman and Neil J. Bulleid .......................... 71
Mechanisms of Membrane Curvature Sensing
Bruno Antonny .............................................. 101
Biogenesis and Cargo Selectivity of Autophagosomes
Hilla Weidberg, Elena Shvets, and Zvulun Elazar ............ 125
Membrane Protein Folding and Insertion Theme
Introduction to Theme "Membrane Protein Folding and
Insertion"
Gunnar von Heijne .......................................... 157
Assembly of Bacterial Inner Membrane Proteins
Ross E. Dalbey, Peng Wang, and Andreas Kuhn ................ 161
β-Barrel Membrane Protein Assembly by the Bam Complex
Christine L. Hagan, Thomas J. Silhavy, and Daniel Kahne .... 189
Transmembrane Communication: General Principles and Lessons
from the Structure and Function of the M2 Proton Channel, K+
Channels, and Integrin Receptors
Gevorg Grigoryan, David T. Moore, and William F. DeGrado ... 211
Biological Mass Spectrometry Theme
Mass Spectrometry in the Postgenomic Era
Brian T. Chait ............................................. 239
Advances in the Mass Spectrometry of Membrane Proteins:
From Individual Proteins to Intact Complexes
Nelson P. Barrera and Carol V. Robinson .................... 247
Quantitative, High-Resolution Proteomics for Data-Driven
Systems Biology
Jürgen Cox and Matthias Mann ............................... 273
Applications of Mass Spectrometry to Lipids and Membranes
Richard Harkewicz and Edward A. Dennis ..................... 301
Cellular Imaging Theme
Emerging In Vivo Analyses of Cell Function Using
Fluorescence Imaging
Jennifer Lippincott-Schwartz ............................... 327
Biochemistry of Mobile Zinc and Nitric Oxide Revealed
by Fluorescent Sensors
Michael D. Pluth, Elisa Tomat, and Stephen J. Lippard ...... 333
Development of Probes for Cellular Functions Using
Fluorescent Proteins and Fluorescence Resonance Energy
Transfer
Atsushi Miyawaki ........................................... 357
Reporting from the Field: Genetically Encoded Fluorescent
Reporters Uncover Signaling Dynamics in Living Biological
Systems
Sohum Mehta and Jin Zhang .................................. 375
Recent Advances in Biochemistry
DNA Replicases from a Bacterial Perspective
Charles S. McHenry ......................................... 403
Genomic and Biochemical Insights into the Specificity of ETS
Transcription Factors
Peter C. Hollenhorst, Lawrence P. McIntosh, and Barbara
J. Graves .................................................. 437
Signals and Combinatorial Functions of Histone
Modifications
Tamaki Suganuma and Jerry L. Workman ....................... 473
Assembly of Bacterial Ribosomes
Zahra Shajani, Michael T. Sykes, and James R. Williamson ... 501
The Mechanism of Peptidyl Transfer Catalysis by the
Ribosome
Edward Ki Yun Leung, Nikolai Suslov, Nicole Tuttle,
Raghuvir Sengupta, and Joseph Anthony Piccirilli ........... 527
Amyloid Structure: Conformational Diversity and Consequences
Brandon H. Toyama and Jonathan S. Weissman ................. 557
AAA+ Proteases: ATP-Fueled Machines of Protein Destruction
Robert T. Sauer and Tania A. Baker ......................... 587
The Structure of the Nuclear Pore Complex
André Hoelz, Erik W. Debler, and Günter Blobel ............. 613
Benchmark Reaction Rates, the Stability of Biological
Molecules in Water, and the Evolution of Catalytic
Power in Enzymes
Richard Wolfenden .......................................... 645
Biological Phosphoryl-Transfer Reactions: Understanding
Mechanism
and Catalysis
Jonathan K. Lassila, Jesse G. Zalatan, and Daniel
Herschlag .................................................. 669
Enzymatic Transition States, Transition-State Analogs,
Dynamics, Thermodynamics, and Lifetimes
Vern L. Schramm ............................................ 703
Class I Ribonucleotide Reductases: Metallocofactor Assembly
and Repair In Vitro and In Vivo
Joseph A. Cotruvo Jr. and JoAnne Stubbe .................... 733
The Evolution of Protein Kinase Inhibitors from Antagonists
to Agonists of Cellular Signaling
Arvin С. Dar and Kevan M. Shokat ........................... 769
Glycan Microarrays for Decoding the Glycome
Cory D. Rillahan and James C. Paulson ...................... 797
Cross Talk Between O-GlcNAcylation and Phosphorylation:
Roles in Signaling, Transcription, and Chronic Disease
Gerald W. Hart, Chad Slawson, Genaro Ramirez-Correa, and
Olof Lagerlof .............................................. 825
Regulation of Phospholipid Synthesis in the Yeast
Saccharomyces cerevisiae
George M. Carman and Gil-Soo Han ........................... 859
Sterol Regulation of Metabolism, Homeostasis, and
Development
Joshua Wollam and Adam Antebi .............................. 885
Structural Biology of the Toll-Like Receptor Family
Jin Young Kang and Jie-Oh Lee .............................. 917
Structure-Function Relationships of the G Domain,
a Canonical Switch Motif
Alfred Wittinghofer and Ingrid R. Vetter ................... 943
STIM Proteins and the Endoplasmic Reticulum-Plasma Membrane
Junctions
Silvia Carrasco and Tobias Meyer ........................... 973
Amino Acid Signaling in TOR Activation
Joungmok Kim and Кun-Liang Guan ........................... 1001
Mitochondrial tRNA Import and Its Consequences
for Mitochondrial Translation
André Schneider ........................................... 1033
Caspase Substrates and Cellular Remodeling
Emily D. Crawford and James A. Wells ...................... 1055
Regulation of HSF1 Function in the Heat Stress Response:
Implications in Aging and Disease
Julius Anckar and Lea Sistonen ............................ 1089
Indexes
Cumulative Index of Contributing Authors, Volumes 76-80 ...... 1117
Cumulative Index of Chapter Titles, Volumes 76-80 ............ 1121
Errata
An online log of corrections to Annual Review of
Biochemistry articles may
be found at http://biochem.annualreviews.org/errata.shtml
|
