The chemical biology of nucleic acids / ed. by G.Mayer. - Chichester: Wiley, 2010. - xiii, 464 p.: ill. - Incl. bibl. ref. - Ind.: p.455-464. - ISBN 978-0-470-51974-5  Место хранения:   056 | Институт химической биологии и фундаментальной медицины CO РАН | Новосибирск| Библиотека

Оглавление / Contents

Foreword ...................................................... vii Preface ........................................................ ix List of Contributors ........................................... xi 1 Chemical Synthesis of Modified RNA ........................... 1 Claudia Hobartner and Falk Wachowius 2 Expansion of the Genetic Alphabet in Nucleic Acids by Creating New Base Pairs ..................................... 39 Ichiro Hirao and Michiko Kimoto 3 Chemical Biology of DNA Replication: Probing DNA Polymerase Selectivity Mechanisms with Modified Nucleotides ................................................. 63 Andreas Marx 4 Nucleic Acid-templated Chemistry ............................ 73 Michael Oberhuber 5 Chemical Biology of Peptide Nucleic Acids (PNAs) ........... 103 Peter E. Nielsen 6 The Interactions of Small Molecules with DNA and RNA ....... 115 Yun Xie, Victor K. Tarn and Yitzhak Tor 7 The Architectural Motifs of Folded RNAs .................... 141 Valérie Fritsch and Eric Westhof 8 Genesis and Biological Applications of Locked Nucleic Acids (LNAs) ............................................... 175 Harleen Kaur and Souvik Maiti 9 Small Non-coding RNA in Bacteria ........................... 199 Sabine Brantl 10 MicroRNA-guided Gene Silencing ............................. 223 Gunter Meister 11 Nucleic Acid-based Therapies ............................... 233 Britta Hoehn and John J. Rossi 12 Innate Immune Recognition of Nucleic Acids ................. 261 Stefan Bauer 13 Light-responsive Nucleic Acids for the Spatiotemporal Control of Biological Processes ............................ 279 Alexander Heckel and Günter Mayer 14 DNA Methylation ............................................ 307 Albert Jeltsch and Renata Z. Jurkowska 15 Frameworks for Programming RNA Devices ..................... 323 Maung Nyan Win, Joe C. Liang and Christina D. Smolke 16 RNA as a Catalyst: The Diels-Alderase Ribozyme ............. 339 Andres Jäschke 17 Evolving an Understanding of RNA Function by In Vitro Approaches ................................................. 355 Qing Wang and Peter J. Unrau 18 The Chemical Biology of Aptamers: Synthesis and Applications ............................................... 377 Günter Mayer and Bernhard Wulffen 19 Nucleic Acids as Detection Tools ........................... 401 Jeffrey C.F. Lam, Sergio Aguirre and Yingfu Li 20 Bacterial Riboswitch Discovery and Analysis ................ 433 Tyler D. Ames and Ronald R. Breaker Index ......................................................... 455