Preface ........................................................ IX
1 Creatine Monohydrate ......................................... 1
Somnath Singh and Alekha K. Dash
1 History and Therapeutic Aspects ........................... 2
2 Description ............................................... 4
3 Synthesis ................................................. 5
4 Physical Properties ....................................... 8
5 Methods of Analysis ...................................... 23
6 Stability and Degradation ................................ 27
7 Pharmacokinetics, Metabolism, and Toxicity ............... 28
Acknowledgments ............................................. 32
References .................................................. 32
2 Cytarabine .................................................. 37
Hussein I. El-Subbagh and Abdullah A. Al-Badr
1 Description .............................................. 38
2 Methods of Preparation ................................... 41
3 Physical Characteristics ................................. 47
4 Methods of Analysis ...................................... 54
5 Radioimmunoassay ......................................... 95
6 Biological Analysis ...................................... 98
7 Stability ............................................... 100
8 Pharmacokinetics, Metabolism, and Excretion ............. 102
9 Pharmacology ............................................ 104
Acknowledgments ............................................ 110
References ................................................. 110
3 J. Famotidine .............................................. 115
Mohamed A. Al-Omar and Abdullah M. Al-Mohizea
1 General Information ..................................... 116
2 Physical Characteristics ................................ 117
3 Stability and Storage ................................... 125
4 Analytical Profiles of Famotidine ....................... 126
5 Drug Metabolism and Pharmacokinetic Profiles of
Famotidine .............................................. 144
References ................................................. 150
4 Fexofenadine Hydrochloride ................................. 153
Lokesh Kumar, Md. Shahnwaj Alam, Chhuttan Lai Meena,
Rahul Jain, and Arvind K. Bansal
1 Description ............................................. 154
2 Methods of Preparation .................................. 156
3 Physical Properties ..................................... 161
4 Methods of Analysis ..................................... 175
5 Stability ............................................... 188
6 Drug Metabolism and Pharmacokinetics .................... 189
Acknowledgments ............................................ 190
References ................................................. 190
5 Itraconazole: Comprehensive Profile ........................ 193
Abdullah A. Al-Badr and Hussein I. El-Subbagh
1 Description ............................................. 194
2 Physical Characteristics ................................ 196
3 Uses and Applications ................................... 205
4 Methods of Chemical Synthesis ........................... 205
5 Methods of Analysis ..................................... 217
6 Food and Drug Interaction ............................... 251
7 Stability ............................................... 253
8 Pharmacokinetics ........................................ 254
9 Absorption, Metabolism, and Excretion ................... 260
Acknowledgment ............................................. 261
References ................................................. 261
6 Ofloxacin .................................................. 265
Mohammed A. Al-Omar
1 Physical Profiles of Ofloxacin .......................... 266
2 Analytical Profiles of Ofloxacin ........................ 276
3 Drug Metabolism and Pharmacokinetic Profiles of
Ofloxacin ............................................... 293
References ................................................. 296
7 Paclitaxel ................................................. 299
Saurabh Jauhari, Somnath Singh, and Alekha K. Dash
1 Introduction ............................................ 301
2 Description ............................................. 307
3 Methods of Preparation .................................. 309
4 Physical Properties ..................................... 312
5 Method of Analysis ...................................... 321
6 Stability ............................................... 324
7 Pharmacokinetics and Metabolism ......................... 328
Acknowledgment ............................................. 339
References ................................................. 339
Cumulative Index .............................................. 345
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