Foreword: Desorption Ionization and Spray Ionization:
Connections and Progress ...................................... vii
R. Graham Cooks
Foreword to the First Edition ................................. xxi
John B. Fenn
Preface ..................................................... xxvii
Richard B. Cole
Contributors ................................................. xxix
Part I Fundamentals of ES
1 On the Mechanism of Electrospray Ionization Mass
Spectrometry (ESIMS) ......................................... 3
Paul Kebarle and Udo H. Verkerk
2 Selectivity in Electrospray Ionization Mass Spectrometry .... 49
Nadja B. Cech and Christie G. Enke
3 Electrochemistry of the Electrospray Ion Source ............. 75
Gary J. Van Berkel and Vilmos Kertesz
4 ESI Source Design .......................................... 123
Andries P. Bruins
Part II Fundamentals of MALDI
5 MALDI Ionization Mechanisms: an Overview ................... 149
Richard Knochenmuss
6 The Development of Matrix-Assisted Laser Desorption/
Ionization Sources ......................................... 185
Peter В. O'Connor
7 A Comparison of MALDI Matrices ............................. 215
Mahmud Hossain and Patrick A. Limbach
8 MALDI Imaging Mass Spectrometry ............................ 245
Alain Brunelle and Olivier Laprévote
Part III ES and MALDI Coupling to Mass Spectrometry
Instrumentation
9 Coupling ESI and MALDI Sources to the Quadrupole Mass
Filter, Quadrupole Ion Trap, Linear Quadrupole Ion Trap,
and Orbitrap Mass Analyzers ................................ 265
Mark E. Bier
10 Time-of-Flight Mass Spectrometry ........................... 345
Robert J. Cotter
11 Fourier Transform Ion Cyclotron Resonance and Magnetic
Sector Analyzers for ESI and MALDI ......................... 365
Jeremy J. Wolff and I. Jonathan Amster
12 Ion Mobility-Mass Spectrometry ............................. 411
John A. McLean, J. Albert Schultz, and Amina S. Woods
Part IV Practical Aspects of ES and MALDI
13 ESI, APCI, and MALDI A Comparison of the Central
Analytical Figures of Merit: Sensitivity, Reproducibility,
and Speed .................................................. 443
Thomas R. Covey, Bradley B. Schneider, Hassan Javaheri,
J.С. Yves LeBlanc, Gordana Ivosev, Jay J. Corr, and
Peter Kovarik
14 Charge State Distributions in Electrospray and MALDI ....... 491
Yan Li and Richard B. Cole
15 Probing Noncovalent Interactions by Electrospray
Ionization and Matrix-Assisted Laser Desorption/
Ionization ................................................. 535
Sonal Mathur, Alexis Nazabal, and Renato Zenobi
16 Ion Activation Methods for Tandem Mass Spectrometry ........ 571
Kristina Håkansson and John S. Klassen
17 Dissociation of Even-Electron Ions ......................... 631
Carlos Afonso, Richard B. Cole, and Jean-Claude Tabet
Part V Biological Applications ofES and MALDI
18 The Role of Mass Spectrometry for Peptide, Protein, and
Proteome Characterization .................................. 685
A. Jimmy Ytterberg, Jason Dunsmore, Shirley H. Lomeli,
Mario Thevis, Yongming Xie, Rachel R. Ogorzalek Loo, and
Joseph A. Loo
19 Carbohydrate Analysis by ESI and MALDI ..................... 723
David J. Harvey
20 Applications of ESI and MALDI to Lipid Analysis ............ 771
Xianlin Han
21 In Vitro ADME Profiling and Pharmacokinetic Screening in
Drug Discovery ............................................. 799
Daniel B. Kassel
Index ......................................................... 825
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