Introduction .................................................... 1
1 The Flow of Energy in Living Systems ......................... 3
References .................................................. 10
2 Origins: The Early Earth .................................... 11
General references .......................................... 29
References .................................................. 29
3 Force and Energy Explored ................................... 31
3.1 Gravitational force .................................... 36
3.2 The electromagnetic force .............................. 40
3.3 The strong nuclear force ............................... 43
3.4 The weak nuclear force ................................. 43
References .................................................. 47
4 Which Way? An Introduction to Thermodynamics ................ 48
General references .......................................... 72
References .................................................. 72
5 The Building Blocks ......................................... 73
General references ......................................... 108
References ................................................. 108
6 How Fast, How Far? Chemical Kinetics and Equilibrium ....... 109
General references ......................................... 138
References ................................................. 138
7 The Strange Story of Water and Oil ......................... 139
General references ......................................... 161
References ................................................. 161
8 Size Matters: Proteins and Enzymes ......................... 162
8.1 Principles of protein structure ....................... 162
8.2 Some very special molecules: enzymes .................. 178
8.3 Regulation of enzyme activity ......................... 189
8.4 Coenzymes, vitamins, and enzyme classification ........ 192
References ................................................. 199
9 Molecular Genetics—the Chemical Basis of Heredity .......... 200
General references ......................................... 222
10 Electron Gymnastics: Energy Revisited ...................... 223
10.1 How many ATP molecules are produced when electrons
traverse the entire ETC? .............................. 233
10.2 What about the rotary engine? ......................... 234
References ................................................. 249
11 Cells and Metabolism: Putting it all Together .............. 250
11.1 General aspects of metabolism ......................... 250
11.2 Glycolysis ............................................ 254
11.3 The reactions of glycolysis ........................... 257
11.4 The pentose phosphate pathway ......................... 265
11.5 The citric acid or tricarboxylic acid cycle ........... 266
11.6 Regulation of the citric acid cycle ................... 271
General references ......................................... 273
References ................................................. 273
12 From Prokaryotes to Eukaryotes: Getting Ready for
Multicellular Life ......................................... 274
General references ......................................... 286
References ................................................. 286
13 Multicellular Life: The Last Hurdle? ....................... 287
13.1 Multicellularity arrives .............................. 287
13.2 The evolution of plants ............................... 290
13.3 The evolution of fungi ................................ 294
13.4 The evolution of animals .............................. 296
13.5 The organization of the mammalian body ................ 300
General references ......................................... 302
References ................................................. 302
Appendix A Electromagnetic Radiation .......................... 303
Appendix В Glycolysis: Chemical Structures of Intermediates ... 311
Appendix С TCA Cycle: Chemical Structures of Intermediates .... 312
Appendix D The Calvin Cycle in Photosynthesis, Showing
Chemical Structures of the Intermediates, and
the Enzymes Involved in each Step .................. 313
Appendix E Amino Acid Structures .............................. 315
Index ......................................................... 319
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