Programmed cell death in protozoa / [ed. by] José Manuel Pérez Martín. - Austin: Landes Bioscience; New York: Springer Science+Business Media, 2008. - 163 p.: ill. - (Molecular biology intelligence unit). - Incl. bibl. ref. - Ind.: p.161-163. - ISBN 978-0-387-76716-1  Место хранения:   056 | Институт химической биологии и фундаментальной медицины CO РАН | Новосибирск| Библиотека

Оглавление / Contents

Preface ........................................................ xv 1 Programmed Cell Death in Protozoa: An Evolutionary Point of View. The Example of Kinetoplastid Parasites .............. 1 Miguel A. Fuertes, Paul A. Nguewa, Josefina Castilla, Carlos Alonso and José Manuel Pérez Martin The Example of PCD in Kinetoplastids as an Heritage of Evolution ................................................. 2 The Hypothesis of PCD in Trypanosomatids as an Adaptative Mechanism and a Defence Strategy ............... 3 Future Prospects .......................................... 4 2 Programmed Cell Death in Protists without Mitochondria: The Missing Link ............................................. 7 Claude-Olivier Sarde and Alberto Roseto Life Origin ............................................... 7 How PCD Was Born ......................................... 11 PCD in Bacteria and Mitochondriate Unicellular Organisms ................................................ 15 PCD in Amitochondriate Unicellular Organisms ............. 18 Perspectives ............................................. 19 3 Programmed Cell Death and Trypanosomatids: A Brief Review ... 24 Maria de Nazaré C. Soeiro and Elen M. de Souza Programmed Cell Death .................................... 24 Programmed Cell Death in Unicellular Eukaryotes .......... 25 Programmed Cell Death in Trypanosomatids ................. 26 Final Considerations ..................................... 35 4 Programmed Cell Death in African Trypanosomes ............... 39 Katherine Figarella, Néstor L. Uzcátegui, Viola Denninger, Susan Welburn and Michael Duszenko General Features of Trypanosoma brucei ................... 39 Programmed Cell Death in Multicellular and Unicellular Organisms ................................................ 41 Programmed Cell Death Phenotype in Trypanosoma brucei .... 41 Central Role of ROS in Trypanosomal PCD .................. 43 Physiological Relevance of PCD in Trypanosoma brucei ..... 45 5 Molecular Analysis of Programmed Cell Death by DNA Topoisomerase Inhibitors in Kinetoplastid Parasite Leishmania .................................................. 49 Nilkantha Sen, Bijoylaxmi Banerjee and Hemanta K. Majumder DNA Topoisomerases in Kinetoplastid Parasites—Why So Unique? .................................................. 49 Role of DNA Topoisomerases in Kinetoplastids ............. 51 DNA Topoisomerases as a Potential Target for Apoptosis ... 51 Significance of Apoptosis in Kinetoplastid Parasites ..... 52 DNA Topoisomerase Mediated Apoptosis in Kinetoplastids Significantly Differs from Mammalian Cells ............... 52 Apoptosis in Kinetoplastid Parasites by DNA Topoisomerase Inhibitors ................................. 54 6 DNA Metalio-Intercalators with Leishmanicidal Activity ...... 59 Maribel Navarro, Gonzalo Visbal and Edgar Marchán Programmed Cell Death (PCD) in Trypanosomatids ........... 60 PCD by Antileishmanial Drugs ............................. 61 Other Leishmanicidal Drugs ............................... 63 Transition Metal Complexes as Antileishmanial Agents ..... 65 DNA as Leishmanicidal Target ............................. 66 7 Programmed Cell Death during Malaria Parasite Infection of the Vertebrate Host and Mosquito Vector .................. 74 Luke A. Baton, Emma Warr, Seth A. Hoffman and George Dimopoulos The Life Cycle of Plasmodium ............................. 75 What Are PCD and Apoptosis? .............................. 75 PCD within Malaria Parasites Themselves .................. 76 PCD of Vertebrate Host Cells Associated with Malaria Infection ................................................ 80 PCD in Mosquito Vector Cells Associated with Malaria Parasite Infection ....................................... 84 8 In Search of Atropos' Scissors: Severing the Life-Thread of Plasmodium ............................................... 91 Marcel Deponte Things to Know about Plasmodium and Malaria .............. 91 Metacaspases as Putative Executors of Cell Death ......... 92 Metacaspase Structure and Function: The Devil Is in the Details .................................................. 94 The Metacaspase Core Domain Is Flanked by a Plasmodium Specific N-Terminal Sequence ............................. 95 9 Cell Death in Trichomonads .................................. 97 Marlene Benchimol Trichomonas Structure ................................... 101 Pseudocyst .............................................. 101 Motility ................................................ 101 Detection of Apoptosis-Like Death in Trichomonads ....... 102 Second Pathway .......................................... 103 Transmembrane Potential Disruption ...................... 103 Plasma Membrane Blebbing and Apoptotic Bodies ........... 103 Hydrogenosomes .......................................... 103 Endoplasmic Reticulum and Golgi Complex Behavior ........ 105 Lysosomes and Vacuoles .................................. 106 Cytoskeleton ............................................ 106 Nucleus Behavior ........................................ 106 Induction of Cell Death in Trichomonads ................. 107 Autophagy ............................................... 107 Necrosis ................................................ 108 10 Programmed Cell Death and the Enteric Protozoan Parasite Blastocysts hominis: Perspectives and Prospects ............ 116 Kevin S.W. Tan PCD in Blastocystis—Apoptotic and Non-Apoptotic Features ................................................ 117 Caspase and Mitochondrial Involvement ................... 119 Alternate Deathstyles of Blastocystis—More than One Way to Kill a Parasite? ................................. 120 Apoptosis of Host Cells by Blastocystis ................. 121 Implications and Future Directions ...................... 122 11 Programmed Cell Death in Dinoflagellates ................... 126 Maria Segovia Which Cell Death Morphology: Apoptotic, Necrotic, "Necrotic-Like" or Paraptotic? .......................... 128 Signalling the Pathway: The Oxidative Burst ............. 132 Ecological Relevance of ROS: Coral Bleaching ............ 134 Metacaspases: Killers of the Cell ....................... 135 Where Did the PCD Genes Come From? ...................... 137 12 Programmed Nuclear Death and Other Apoptotic-Like Phenomena in Ciliated Protozoa ............................. 143 Ana Martín González, Silvia Díaz, Andrea Gallego and Juan C. Gutiérrez Introduction: Ciliate Organization Indicate That They Are Singular Eukaryotic Microorganisms .................. 143 A Complex Life Cycle with Diverse Alternatives .......... 145 Nuclear Phenomena during Conjugation of Tetrahymena Thermophila ............................................. 146 Programmed Nuclear Death during Conjugation in Tetrahymena: An Apoptotic-Like Process? ................. 147 Different Involvement of Caspase-Like Activities in Programmed Nuclear Death ................................ 149 Autophagosome Formation and Lysosomal Enzymes Participate in Old Macronuclei Elimination .............. 150 Mitochondria Might Be also Involved in Tetrahymena's PND ..................................................... 151 Other Cases of PND Described in Free-Living Ciliated Protozoa ................................................ 152 Apoptotic-Like Processes Induced in Ciliates Support the Autophagy Implication in PND ........................ 154 Concluding Remarks and Future Prospects ................. 155 Index ......................................................... 161