Preface ........................................................ ii
1. Introduction: Still More Questions than Answers ............. 3
William Jagust and Mark D'Esposito
2. Methodological and Conceptual Issues in the Study of the
Aging Brain ................................................ 11
Mark D'Esposito, William Jagust, and Adam Gazzaley
3. Neuropathology of Aging .................................... 27
Dara L. Dickstein, John H. Morrison, and Patrick R. Hof
PART I BASIC SCIENCE
4. A Systems Approach to the Aging Brain: Neuroanatomic
Changes, Their Modifiers, and Cognitive Correlates ......... 43
Naftali Raz and Kristen M. Kennedy
5. Dopaminergic Modulation of Cognition in Human Aging ........ 71
Shu-Chen Li, Ulman Lindenberger, Lars Nyberg, Hauke R.
Heekeren, and Lars Bäckman
6. Cognitive Reserve and Aging ................................ 93
Yaakov Stern
7. Compensatory Reorganization of Brain Networks in Older
Adults .................................................... 105
Cheryl L. Grady
8. Cross-Species Imaging Applied to the Aging Brain:
Dissociating Alzheimer's Disease from Normal Aging ........ 115
Sidonie T. Jones and Scott A. Small
9. Genetics and Imaging in Alzheimer's Disease ............... 123
Susan Y. Bookheimer
PART II CLINICAL APPLICATIONS
10. Imaging Cognitive Decline in Aging: Predicting Decline
with Structural Imaging ................................... 135
Jeffrey Kaye
11. The Early Detection of Alzheimer's Disease with Positron
Emission Tomography ....................................... 151
Rachel Mistur, Lisa Mosconi, Remigiusz Switalski, Susan
De Santi, Yi Li, Lidia Glodzik, Miroslaw Brys, Wai Tsui,
Henry Rusinek, and Mony J. de Leon
12. Structural Imaging of Mild Cognitive Impairment ........... 169
Clifford R. Jack, Jr.
13. Functional Imaging with FDG-PET in Mild Cognitive
Impairment ................................................ 183
Karl Herholz
14. Amyloid Imaging and (What is "Normal"?) Aging ............. 191
William E. Klunk and Chester A. Mathis
15. Differential Diagnosis of Dementia Using Functional
Neuroimaging .............................................. 245
Eric Salmon, Fabienne Collette, and Gaёtan Garraux
16. MRI and the Differential Diagnosis of Dementia ............ 261
António J. Bastos-Leite and Philip Scheltens
17. White Matter Hyperintensities in Aging and Dementia ....... 273
Adriane Mayda, Mitsuhiro Yoshita, and Charles DeCarli
18. Functional MRI Studies in Aging and Early Alzheimer's
Disease: Predicting Clinical Decline ...................... 293
Reisa Sperling
19. MRI as a Surrogate Marker in Clinical Trials in
Alzheimer's Disease ....................................... 305
Frank Jessen and Harald Hampel
20. Brain Imaging in the Evaluation of Putative Alzheimer's
Disease-Slowing, Risk-Reducing and Prevention Therapies ... 319
Eric M. Reiman and Jessica B.S. Langbaum
21. Databasing the Aging Brain ................................ 351
John Darrell Van Horn and Arthur W. Toga
Index ......................................................... 361
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