Preface ........................................................ ix
Contributors ................................................... xi
PART I
1 Cell Fates ................................................... 3
Arthur B. Pardee
2 Architectural Organization of the Regulatory Machinery for
Transcription, Replication, and Repair: Dynamic Temporal-
Spatial Parameters of Cell Cycle Control .................... 15
Corey D. Braastad, Sayyed K. Zaidi, Martin Montecino,
Jane B. Lian, André J. van Wijnen, Janet L. Stein, and
Gary S. Stein
PART II
3 Cell Cycle Regulatory Cascades .............................. 95
Heide L. Ford, Robert A. Sclafani, and James Degregori
4 Membrane Receptors and Signal Transduction Pathways in G,:
Regulation of Liver Regeneration and T Cell
Proliferation .............................................. 129
Joseph F. Porter and David T. Denhardt
5 Onset of DNA Synthesis and S Phase ......................... 149
G. Prem-Veer Reddy, Eugenia Cifuentes, Uma Bai, Mani
Menon, and Evelyn R. Barrack
6 The Progression and Regulation of Mitotic Events ........... 201
Greenfield Sluder, Edward H. Hinchcliffe, and Conly
L. Rieder
7 Cell Cycle Inhibitory Proteins ............................. 237
Carmen Carneiro and Andrew Koff
8 Chromatin Remodeling and Cancer ............................ 265
Cynthia J. Guidi and Anthony N. Imbalzano
9 Extracellular Matrix:Tissue-Specific Regulator of Cell
Proliferation .............................................. 297
Aylin Rizki and Mina J. Bissell
10 Angiogenesis and Blood Supply .............................. 333
Judah Folkman
11 Regulation of Cell Growth, Differentiation, and Death
during Metamorphosis ....................................... 369
Hans Laufer and Eric H. Baehrecke
12 Translational Control and the Cell Cycle ................... 397
Robert E. Rhoads
PART III
13 Telomere Structure and Function Provides Insights into
the Generation of Genomic Instability and
Carcinogenesis ............................................. 451
Colleen Fordyce and Thea D. Tlsty
14 Immortalization by SV40 Large T Antigen .................... 467
Rowena L. Lock, Silvia Benvenuti, and Parmjit S. Jat
15 Apoptosis Signaling in Normal and Cancer Cells ............. 497
Shulin Wang and Wafik S. El-Deiry
PART IV
16 Mutagenesis, Mutations, and DNA Repair ..................... 525
Roger D.Johnson
17 Oncogenes .................................................. 571
Stacey J. Baker and E. Premkumar Reddy
18 Role of the Retinoblastoma Family in Cell Cycle
Progression and Growth Control ............................. 607
Valeria Masciullo and Antonio Giordano
19 p53 Tumor-Suppressor Genes ................................. 635
Faith A. Zamamiri-Davis and Cerard P. Zambetti
PART V
20 Cell Cycle and Growth Control: Current Clinical
Applications ............................................... 669
Michael Deininger
PART VI
21 Misregulated Fate—Cancer ................................... 707
Arthur B. Pardee
Index ......................................................... 773
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