Symposium on New perspectives on mitochondrial biology,
held at the Novariis Foundation, London, 28—30 November 2006
Editors: Derek J. Chadwick (Organiser) and Jamie Goode
This symposium is based on a proposal by Michael Duchen
David G. Nicholls.
Chair's introduction ......................................... 1
Albert Neutzner, Richard J. Youle and Mariusz Karbowski
Outer mitochondrial membrane protein degradation by
the proteasome ............................................... 4
Discussion .................................................. 14
Sarah E. Haigh, Gilad Twig, Anthony A.J. Molina, Jakob
D. Wikstrom, Motti Deutsch and Orian S. Shirihai.
PA-GFP: a window into the subcellular adventures of
the individual mitochondrion ................................ 21
Discussion .................................................. 36
Luca Scorrano
Multiple functions of mitochondria-shaping proteins ......... 47
Discussion .................................................. 55
Bruce M. Spiegelman
Transcriptional control of mitochondrial energy metabolism
through the PGC1 coactivators ............................... 60
Discussion .................................................. 63
Charles Affourtit, Paul G. Crichton, Nadeene Parker and
Martin D. Brand
Novel uncoupling proteins ................................... 70
Discussion .................................................. 80
Cecilia Giulivi
Mitochondria as generators and targets of nitric oxide ...... 92
Discussion ................................................. 100
György Hajnóczky, Masao Saotome, György Csordás, David
Weaver and Muqing Yi
Calcium signalling and mitochondrial motility .............. 105
Discussion ................................................. 117
Anna Romagnoli, Paola Aguiari, Diego De Stefani, Sara Leo,
Saverio Marchi, Alessandro Rimessi, Erika Zecchini, Paolo
Pinton and Rosario Rizzuto
Endoplasmic reticulum / mitochondria calcium cross-talk .... 122
Discussion ................................................. 131
Brian O'Rourke, Sonia Cortassa, Fadi Akar and Miguel Aon
Mitochondrial ion channels in cardiac function and
dysfunction ................................................ 140
Discussion ................................................. 152
Paolo Bernardi and Michael Forte
The mitochondrial permeability transition pore ............. 157
Discussion ................................................. 164
Dominic James, Philippe A. Parone, Olivier Terradillos,
Safa Lucken-Ardjomande, Sylvie Montessuit and Jean-Claude
Martinou
Mechanisms of mitochondrial outer membrane
permeabilization ........................................... 170
Discussion ................................................. 176
M. Flint Beal
Mitochondria and neurodegeneration ......................... 183
Discussion ................................................. 192
Mügen Terzioglu and Nils-Göran Larsson
Mitochondrial dysfunction in mammalian ageing .............. 197
Discussion ................................................. 208
Eric A. Schon and Salvatore DiMauro
Mitochondrial mutations: genotype to phenotype ............. 214
Discussion ................................................. 226
Contributor Index ............................................. 234
Subject index ................................................. 236
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