The Power of One
James E. Rothman ............................................. v
Prefatory Article
Frontispiece
Aaron Klug ................................................. xiv
From Virus Structure to Chromatin: X-ray Diffraction
to Three-Dimensional Electron Microscopy
Aaron Klug ................................................... 1
Recent Advances in Biochemistry
Genomic Screening with RNAi: Results and Challenges
Stephanie Mohr, Chris Bakal, and Norbert Perrimon ........... 37
Nanomaterials Based on DNA
Nadrian С. Seeman ........................................... 65
Eukaryotic Chromosome DNA Replication: Where, When, and How?
Hisao Masai, Seiji Matsumoto, Zhiying You, Naoko
Yoshizawa-Sugata, and Masako Oda ............................ 89
Regulators of the Cohesin Network
Bo Xiong and Jennifer L. Gerton ............................ 131
Reversal of Histone Methylation: Biochemical and Molecular
Mechanisms of Histone Demethylases
Nima Mosammaparast and Yang Shi ............................ 155
The Mechanism of Double-Strand DNA Break Repair by the
Nonhomologous DNA End-Joining Pathway
Michael R. Lieber .......................................... 181
The Discovery of Zinc Fingers and Their Applications in Gene
Regulation and Genome Manipulation
Aaron Klug ................................................. 213
Origins of Specificity in Protein-DNA Recognition
Remo Rohs, Xiangshu Jin, Sean M. West, Rohit Joshi, Barry
Honig, and Richard S. Mann ................................. 233
Transcript Elongation by RNA Polymerase II
Luke A. Selth, Stefan Sigurdsson, and Jesper
Q. Svejstrup ............................................... 271
Biochemical Principles of Small RNA Pathways
Qinghua Liu and Zain Paroo ................................. 295
Functions and Regulation of UNA Editing by AD AR Deaminases
Kazuko Nishikura ........................................... 321
Regulation of mRNA Translation and Stability by microRNAs
Marc Robert Fabian, Nahum Sonenberg, and Witold
Filipowicz ................................................. 351
Structure and Dynamics of a Processive Brownian Motor:
The Translating Ribosome
Joachim Frank and Ruben L. Gonzalez, Jr. ................... 381
Adding New Chemistries to the Genetic Code
Chang C. Liu and Peter G. Schultz .......................... 413
Bacterial Nitric Oxide Synthases
Brian R. Crane, Jawahar Sudhamsu, and Bhumit A. Patel ...... 445
Enzyme Promiscuity: A Mechanistic and Evolutionary
Perspective
Olga Khersonsky and Dan S. Tawfik .......................... 471
Hydrogenases from Methanogenic Archaea, Nickel, a Novel
Cofactor, and H2 Storage
Rudolf K. Thauer, Anne-Kristin Kaster, Meike Goenrich,
Michael Schick, Takeshi Hiromoto, and Seigo Shima .......... 507
Copper Metallochaperones
Nigel J. Robinson and Dennis R. Winge ...................... 537
High-Throughput Metabolic Engineering: Advances in Small-
Molecule Screening and Selection
Jeffrey A. Dietrich, Adrienne E. McKee, and Jay D.
Keasling ................................................... 563
Botulinum Neurotoxin: A Marvel of Protein Design
Mauricio Montal ............................................ 591
Chemical Approaches to Glycobiology
Laura L. Kiessling and Rebecca A. Splain ................... 619
Cellulosomes: Highly Efficient Nanomachines Designed to
Deconstruct Plant Cell Wall Complex Carbohydrates
Carlos M.G.A. Fontes and Harry J. Gilbert .................. 655
Somatic Mitochondrial DNA Mutations in Mammalian Aging
Nils-Göran Larsson ......................................... 683
Physical Mechanisms of Signal Integration by WASP Family
Proteins
Shae B. Padrick and Michael K. Rosen ....................... 707
Amphipols, Nanodiscs, and Fluorinated Surfactants: Three
Nonconventional Approaches to Studying Membrane Proteins in
Aqueous Solutions
Jean-Luc Popot ............................................. 737
Protein Sorting Receptors in the Early Secretory Pathway
Julia Dancourt and Charles Barlowe ......................... 777
Virus Entry by Endocytosis
Jason Mercer, Mario Schelhaas, and Ari Helenius ............ 803
Indexes
Cumulative Index of Contributing Authors, Volumes 75-79 ....... 835
Cumulative Index of Chapter Titles, Volumes 75-79 ............. 839
Errata
An online log of corrections to Annual Review of Biochemistry
articles may be found at http://biochem.annualreviews.org
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