Preface ....................................................... vii
Acknowledgments ................................................ xi
Summary ........................................................ xv
1 Introduction ................................................. 1
1.1 Introduction ............................................ 1
1.2 Structure of This Book .................................. 6
Part I
PAL: EMPIRICAL ASSESSMENT ...................................... 13
2 Effectiveness of Integrated Syndromic Lung Health-Guidelines
in Patients with Breathing Difficulties in Rural Nepal ...... 15
2.1 Introduction ........................................... 16
2.2 Methods ................................................ 17
2.3 Results ................................................ 19
2.4 Discussion and Conclusion .............................. 26
3 Health-Related Quality of Life of Adults in Nepal with
Respiratory Symptoms, Using WHOQOL and EQ-5D ................ 30
3.1 Introduction ........................................... 31
3.2 HRQOL Instruments ...................................... 33
3.3 Methods ................................................ 36
3.4 Results ................................................ 39
3.5 Discussion ............................................. 46
4 Practical Approach to Lung Health in Nepal: Improving
Prescription Behavior and Reducing Costs .................... 51
4.1 Introduction ........................................... 52
4.2 Methods and Materials .................................. 52
4.3 Results ................................................ 56
4.4 Discussion ............................................. 59
Part II
PAL: MODELING POPULATION LUNG HEALTH ........................... 65
5 Multistate Models to Study Lung Diseases: A Review .......... 67
5.1 Introduction ........................................... 67
5.2 PAL Diseases ........................................... 68
5.3 Review ................................................. 71
5.4 Conclusion and Inference for PAL ....................... 87
6 Defining Disease States in Health Modeling Based on
Quality of Life: An Alternative for Modeling Disease
States Based on Prognostic Variables ........................ 92
6.1 Introduction ........................................... 92
6.2 Methods ................................................ 94
6.3 Results ................................................ 99
6.4 Discussion and Conclusion ............................. 103
7 The Health Effects and Medical Costs of the WHO's
Practical Approach to Lung Health for the Nepalese
Population - A Model-Based Analysis Using Cluster-
Randomized Trial Data ...................................... 106
7.1 Introduction .......................................... 107
7.2 Methods ............................................... 108
7.3 Results ............................................... 114
7.4 Discussion ............................................ 115
8 Conclusion and Discussion .................................. 125
8.1 Conclusion ............................................ 125
8.2 Discussion ............................................ 127
Longaandoeningen in ruraal Nepal .............................. 131
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