Preface ......................................................... v
Prefatory Articles
Frontispiece
E. Peter Geiduschek ........................................ xii
Without a License, or Accidents Waiting to Happen
E. Peter Geiduschek .......................................... 1
Frontispiece
James C. Wang ............................................... 30
A Journey in the World of DNA Rings and Beyond
James C. Wang ............................................... 31
Biochemistry and Disease Theme
The Biochemistry of Disease: Desperately Seeking Syzygy
John W. Kozarich ............................................ 55
Biosynthesis of Phosphonic and Phosphinic Acid Natural
Products
William W. Metcalf and Wilfred A. van der Donk .............. 65
New Antivirals and Drug Resistance
Peter M. Colman ............................................. 95
Multidrug Resistance in Bacteria
Hiroshi Nikaido ............................................ 119
Conformational Pathology of the Serpins: Themes,
Variations, and Therapeutic Strategies
Bibek Gooptu and David A. Lomas ............................ 147
Getting a Grip on Prions: Oligomers, Amyloids, and
Pathological Membrane Interactions
Byron Caughey, Gerald S. Baron, Bruce Chesebro, and
Martin Jeffrey ............................................. 177
Ubiquitin-Mediated Protein Regulation
RING Domain E3 Ubiquitin Ligases
Raymond J. Deshaies and Claudio A.P. Joazeiro .............. 399
Regulation and Cellular Roles of Ubiquitin-Specific
Deubiquitinating Enzymes
Francisca E. Reyes-Turcu, Karen H. Ventii, and
Keith D. Wilkinson ......................................... 363
Recognition and Processing of Ubiquitin-Protein Conjugates
by the Proteasome
Daniel Finley .............................................. 477
Degradation of Activated Protein Kinases by Ubiquitination
Zhimin Lu and Tony Hunter .................................. 435
The Role of Ubiquitin in NF-kB Regulatory Pathways
Brian Skaug, Xiaomo Jiang, and Zhijian J. Chen ............. 769
Biological and Chemical Approaches to Diseases of
Proteostasis Deficiency
Evan T. Powers, Richard I. Morimoto, Andrew Dillin,
Jeffery W. Kelly, and William E. Balch ..................... 959
Gene Expression
RNA Polymerase Active Center: The Molecular Engine
of Transcription
Evgeny Nudler .............................................. 335
Genome-Wide Views of Chromatin Structure
Oliver J. Rando and Howard Y. Chang ........................ 245
The Biology of Chromatin Remodeling Complexes
Cedric R. Clapier and Bradley R. Cairns .................... 273
The Structural and Functional Diversity of Metabolite-
Binding Riboswitches
Adam Roth and Ronald R. Breaker............................. 305
Lipid and Membrane Biogenesis
Genetic and Biochemical Analysis of Non-Vesicular
Lipid Traffic
Dennis R. Voelker .......................................... 827
Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol
Turnover in the Brain
David W. Russell, Rebekkah W. Halford, Denise M.O.
Ramirez, Rahul Shah, and Tiina Kotti ...................... 1017
Lipid-Dependent Membrane Protein Topogenesis
William Dowhan and Mikhail Bogdanov ........................ 515
Single-Molecule Studies of the Neuronal SNARE Fusion
Machinery
Axel T. Brunger, Keith Weninger, Mark Bowen, and
Steven Chu ................................................. 903
Mechanisms of Endocytosis
Gary J. Doherty and Harvey T. McMahon ...................... 857
Recent Advances in Biochemistry
Motors, Switches, and Contacts in the Replisome
Samir M. Hamdan and Charles C. Richardson .................. 205
Large-Scale Structural Biology of the Human Proteome
Aled Edwards ............................................... 541
Collagen Structure and Stability
Matthew D. Shoulders and Ronald T. Raines .................. 929
The Structural and Biochemical Foundations of Thiamin
Biosynthesis
Christopher T. Jurgenson, Tadhg R. Begley, and
Steven E. Ealick ........................................... 569
Proton-Coupled Electron Transfer in Biology: Results from
Synergistic Studies in Natural and Model Systems
Steven Y. Reece and Daniel G. Nocera ....................... 673
Mechanism of Mo-Dependent Nitrogenase
Lance C. Seefeldt, Brian M. Hoffman, and Dennis R. Dean .... 701
Inorganic Polyphosphate: Essential for Growth and Survival
Narayana N. Rao, María R. Gómez-García, and
Arthur Kornberg ............................................ 605
Essentials for ATP Synthesis by F1F0 ATP Synthases
Christoph von Ballmoos, Alexander Wiedenmann, and
Peter Dimroth .............................................. 649
The Chemical Biology of Protein Phosphorylation
Mary Katherine Tarrant and Philip A. Cole .................. 797
Sphingosine 1-Phosphate Receptor Signaling
Hugh Rosen, Pedro J. Gonzalez-Cabrera, M. Germana Sanna,
and Steven Brown ........................................... 743
The Advent of Near-Atomic Resolution in Single-Particle
Electron Microscopy
Yifan Cheng and Thomas Walz ................................ 723
Super-Resolution Fluorescence Microscopy
Bo Huang, Mark Bates, and Xiaowei Zhuang ................... 993
Indexes
Cumulative Index of Contributing Authors, Volumes 74-78 ...... 1041
Cumulative Index of Chapter Titles, Volumes 74-781045 ........ 1045
Errata
An online log of corrections to Annual Review of
Biochemistry articles may be found at
http://biochem.annualreviews.org/errata.shtml
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