Preface ........................................................ ix
Acknowledgments ................................................ xi
About the Editors ............................................ xiii
Contributors ................................................... xv
Chapter 1. MicroMining: Computational Approaches to microRNA
Discovery ............................................ 1
Adam Grundhoff
Chapter 2. Animal microRNA Gene Prediction ..................... 21
Ola Snøve and Pal Scetrom
Chapter 3. A Suite of Resources for the Study of microRNA
Ontology and Function ............................... 45
Praveen Sethupathy, Molly Megraw, and
Artemis G. Hatzigeorgiou
Chapter 4. Regulation of Translation and mRNA Stability by
Hfq-Binding Small RNAs in Escherichia coli .......... 57
Hiroji Aiba
Chapter 5. Mechanisms by which microRNAs Regulate Gene
Expression in Animal Cells .......................... 77
Yang Yu and Timothy W. Nilsen
Chapter 6. The microRNAs of Caenorhabditis elegans ............. 89
Mona J. Nolde and Frank J. Slack
Chapter 7. Isolation and Characterization of Small RNAs in
Caenorhabditis elegans ............................. 101
Chisato Ushida and Yusuke Hokii
Chapter 8. MicroRNA Tales in Fly Development .................. 123
Utpal Bhadra, Sunit Kumar Singh, S.N.C.V.L.
Pushpavalli, Praveensingh B. Hajeri, and
Manika Pal-Bhadra
Chapter 9. RNA Interference and microRNAs in Zebra Fish ....... 149
Alex S. Flynt, Elizabeth J. Thatcher, and
James G. Patton
Chapter 10.Biogenesis and Function of Plant microRNAs ......... 173
Zoltan Havelda
Chapter 11.Endogenous Small RNA Pathways in Arabidopsis ....... 197
Manu Agarwal, Julien Curaba, and Xuemel Chen
Chapter 12.How to Assay microRNA Expression: A Technology
Guide .............................................. 215
Mirco Castoldi, Vladimir Benes, and Martina
U. Muckenthaler
Chapter 13.Methods to Quantify microRNA Gene Expression ....... 241
Lori A. Neely
Chapter 14.Regulation of Alternative Splicing by microRNAs .... 259
Rajesh K. Gaur
Chapter 15.Recent Progress in Polymerase II-Mediated
Intronic microRNA Expression Systems ............... 275
Shi-Lung Lin and Shao-Yao Ying
Chapter 16.MicroRNA-Based RNA Polymerase II Expression
Vectors for RNA Interference in Mammalian Cells .... 301
Anne B. Vojtek, Kwan-Ho Chung, Paresh
D. Patel, and David L. Turner
Chapter 17.Transgenic RNAi: A Fast and Low-Cost Approach
to Reverse Genetics in Mammals ..................... 317
Linghua Qiu and Zuoshang Xu
Chapter 18.Symphony of AIDS: A microRNA-Based Therapy ......... 333
Yoichi R. Fujii
Chapter 19.MicroRNAs and Cancer: Connecting the Dots .......... 351
Sumedha D. Jayasena
Chapter 20.Mammalian Transcriptional Gene Silencing by
Small RNAs ......................................... 393
Daniel H. Kim and John J. Rossi
Chapter 21.Regulation of Gene Expression by RNA-Mediated
Transcriptional Gene Silencing ..................... 405
Kevin V. Morris
Index ......................................................... 419
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